...K. L. Evemy; P. Cummins; W. A. Littler 1. The effect of prolonged administration of β-adrenoreceptor-blocking agents was studied in growing rabbits. Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. 2. Animals given propranolol had a significantly lower heart rate...

...R. D. S. Watson; T. J. Stallard; W. A. Littler 1. Sensitivity of the sino-aortic baroreflex was investigated before and after acute (23 patients) and chronic (23 patients) β-adrenoreceptor antagonism in patients with essential hypertension. 2. Sensitivity was inversely related to age ( r = −0·60...

... stimulated release of active renin is associated with removal of inactive renin from the circulation by the kidney. This may in fact be due to intrarenal transformation of circulating inactive renin into its active counterpart. The findings suggest that a β-adrenoreceptor might be involved in this activation...

... associated with frusemide diuresis. 4. Blockade of β-adrenoreceptors with propranolol, by contrast, reduced blood AII increments associated with all three procedures. 5. It is suggested that renin release during moderate haemorrhage and acute suprarenal aortic stenosis is, in the dog, partly due...

...D. Pugsley; B. Armstrong; M. Nassim; L. J. Beilin 1. Labetalol (AH 5158) is a new drug which has both α- and β-adrenoreceptor antagonist activity. Labetalol has been compared with propranolol and placebo for the treatment of mild to moderate hypertension (150/100 to 189/114 mmHg), in a double-blind...

... The Biochemical Society and the Medical Research Society 1976 β-adrenoreceptor catecholamines isolated glomeruli juxtaglomerular cells renin release sodium concentration superfusion Clinical Science and Molecular Medicine (1916) 51.91s-99s. Renin release from isolated rat glomeruli S. H O L D S W O...

... in group 2 before treatment. Thus, in this latter subgroup, low-renin profiles might reflect reduced β-adrenoreceptor activity. 5. Plasma aldosterone was lower in group 2 but appeared to be inappropriately high relative to renin. 6. The data suggest that in hypertensive patients classified according...