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Keywords: β-cell mass
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Articles

VMP1-related autophagy induced by a fructose-rich diet in β-cells: its prevention by incretins

Bárbara Maiztegui, Verónica Boggio, Carolina L. Román, Luis E. Flores, Héctor Del Zotto, Alejandro Ropolo, Daniel Grasso, María I. Vaccaro, Juan J. Gagliardino
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (8): 673–687.
https://doi.org/10.1042/CS20170010
Published: 28 March 2017
...Bárbara Maiztegui; Verónica Boggio; Carolina L. Román; Luis E. Flores; Héctor Del Zotto; Alejandro Ropolo; Daniel Grasso; María I. Vaccaro; Juan J. Gagliardino The aim of the present study was to demonstrate the role of autophagy and incretins in the fructose-induced alteration of β-cell mass...
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Articles

Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats

Bárbara Maiztegui, María I. Borelli, Viviana G. Madrid, Héctor Del Zotto, María A. Raschia, Flavio Francini, María L. Massa, Luis E. Flores, Oscar R. Rebolledo, Juan J. Gagliardino
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (2): 73–80.
https://doi.org/10.1042/CS20100372
Published: 08 October 2010
... indexes, and liver triacylglycerol content were significantly higher in F rats. Islet β-cell mass was significantly lower in these rats, due to an increase in the percentage of apoptosis. The administration of exendin-4 and sitagliptin to F animals prevented the development of all the metabolic...
View article titled, Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats
Open the PDF for Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats in another window