...W. Gaida; R. E. Lang; K. Kraft; Th. Unger; D. Ganten 1. Changes in brain neuropeptide content in spontaneously hypertensive rats may be primarily related to the development of hypertension or may be secondary consequences of it. 2. We have measured brain concentrations of β-endorphin, Leu...

.... This fall was prevented by pretreatment with naloxone, either 1 mg/kg subcutaneously or 1 and 10 ng administered directly into the nucleus. 4. Pretreatment with antiserum to β-endorphin (1:50 dilution), applied locally, also blocked the depressor response induced by the catecholamine. 5. These results...

...M. A. Petty; J. M. A. Sitsen; W. De Jong 1. The role of opiates in cardiovascular regulation has been investigated. 2. In urethane-anaesthetized renal hypertensive rats (two-kidney, one-clip Goldblatt model), intracerebroventricular β-endorphin (10 μg) caused a greater fall in mean arterial...

...J. S. Hutchinson; R. Di Nicolantonio; A. Lim; J. Clements; J. W. Funder 1. Immunoreactive β-endorphin (IR-βEP) was two- to three-fold higher in pituitary neuro-intermediate lobes (N-IL) of spontaneously hypertensive rats (SHR) than of normotensive Wistar—Kyoto (NT-WKY) controls. 2. Plasma levels...