... and fetal oxidative stress, as well as down-regulation of placental 11β-HSD (11β-hydroxysteroid dehydrogenase). Decreased placental 11β-HSD activity increases fetal exposure to maternal glucocorticoids, further increasing fetal oxidative stress. To explore the developmental origins of co-morbid hypertension...

... glucocorticoids 11β-hydroxysteroid dehydrogenase osteoblasts osteoporosis prednisolone The epidemiology of GIOP has been difficult to define due to the wide variability in glucocorticoid doses used clinically, the impact of the underlying disease being treated and the large numbers of subjects...

...Simon C. Langley-Evans 1. In the rat low birthweight and raised systolic blood pressure are the consequence of fetal exposure to maternal low protein diets. Nutritional down-regulation of the placental isoform of 11β-hydroxysteroid dehydrogenase, which may increase exposure of the fetus to maternal...

...P. M. Stewart; A. M. Wallace; S. M. Atherden; C. H. Shearing; C. R. W. Edwards 1. 11β-Hydroxysteroid dehydrogenase is an enzyme complex consisting of 11β-dehydrogenase and 11-oxoreductase responsible for the interconversion of cortisol to cortisone in man. Inhibition of 11β-dehydrogenase (e.g...