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Keywords: 11β-hydroxysteroid dehydrogenase
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Articles
Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice
Available to PurchaseRobert D. Roghair, John A. Wemmie, Kenneth A. Volk, Thomas D. Scholz, Fred S. Lamb, Jeffrey L. Segar
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (10): 427–436.
Published: 25 July 2011
... and fetal oxidative stress, as well as down-regulation of placental 11β-HSD (11β-hydroxysteroid dehydrogenase). Decreased placental 11β-HSD activity increases fetal exposure to maternal glucocorticoids, further increasing fetal oxidative stress. To explore the developmental origins of co-morbid hypertension...
Articles
Sensitivity of bone to glucocorticoids
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (2): 111–123.
Published: 27 July 2004
... enable improved estimates of risk and generate new approaches to the development of bone-sparing anti-inflammatory drugs. 8 3 2004 14 4 2004 28 4 2004 28 4 2004 The Biochemical Society 2004 bone glucocorticoids 11β-hydroxysteroid dehydrogenase osteoblasts osteoporosis...
Articles
Maternal Carbenoxolone Treatment Lowers Birthweight and Induces Hypertension in the Offspring of Rats Fed a Protein-Replete Diet
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (5): 423–429.
Published: 01 November 1997
...Simon C. Langley-Evans 1. In the rat low birthweight and raised systolic blood pressure are the consequence of fetal exposure to maternal low protein diets. Nutritional down-regulation of the placental isoform of 11β-hydroxysteroid dehydrogenase, which may increase exposure of the fetus to maternal...
Articles
Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11 β -hydroxysteroid dehydrogenase activity in man
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (1): 49–54.
Published: 01 January 1990
...P. M. Stewart; A. M. Wallace; S. M. Atherden; C. H. Shearing; C. R. W. Edwards 1. 11β-Hydroxysteroid dehydrogenase is an enzyme complex consisting of 11β-dehydrogenase and 11-oxoreductase responsible for the interconversion of cortisol to cortisone in man. Inhibition of 11β-dehydrogenase (e.g...
