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Keywords: 11β-hydroxysteroid dehydrogenaseClose
Robert D. Roghair, John A. Wemmie, Kenneth A. Volk, Thomas D. Scholz, Fred S. Lamb, Jeffrey L. Segar
Clin Sci (Lond) (2011) 121 (10): 427–436.
Published: 25 July 2011
... and fetal oxidative stress, as well as down-regulation of placental 11β-HSD (11β-hydroxysteroid dehydrogenase). Decreased placental 11β-HSD activity increases fetal exposure to maternal glucocorticoids, further increasing fetal oxidative stress. To explore the developmental origins of co-morbid hypertension...
Clin Sci (Lond) (2004) 107 (2): 111–123.
Published: 27 July 2004
... enable improved estimates of risk and generate new approaches to the development of bone-sparing anti-inflammatory drugs. bone glucocorticoids 11β-hydroxysteroid dehydrogenase osteoblasts osteoporosis prednisolone The adverse effects of glucocorticoids on the skeleton were first...
Clin Sci (Lond) (1997) 93 (5): 423–429.
Published: 01 November 1997
...Simon C. Langley-Evans 1. In the rat low birthweight and raised systolic blood pressure are the consequence of fetal exposure to maternal low protein diets. Nutritional down-regulation of the placental isoform of 11β-hydroxysteroid dehydrogenase, which may increase exposure of the fetus to maternal...
Clin Sci (Lond) (1990) 78 (1): 49–54.
Published: 01 January 1990
...P. M. Stewart; A. M. Wallace; S. M. Atherden; C. H. Shearing; C. R. W. Edwards 1. 11β-Hydroxysteroid dehydrogenase is an enzyme complex consisting of 11β-dehydrogenase and 11-oxoreductase responsible for the interconversion of cortisol to cortisone in man. Inhibition of 11β-dehydrogenase (e.g...