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Keywords: 20-hydroxyeicosatetraenoic acid (20-HETE)
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Articles

Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat

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Kathleen M. Lukaszewicz, Julian H. Lombard
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (12): 695–700.
https://doi.org/10.1042/CS20120483
Published: 26 February 2013
... Journal compilation © 2013 Biochemical Society 2013 cerebral circulation cytochrome P450-4A (CYP4A) 20-hydroxyeicosatetraenoic acid (20-HETE) oxidative stress salt-sensitive vascular function 20-HETE (20-hydroxyeicosatetraenoic acid), a vasoconstrictor metabolite of arachidonic acid...
View articletitled, Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat
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Articles

Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5 BN consomic rats

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Kathleen M. Lukaszewicz, John R. Falck, Vijaya L. Manthati, Julian H. Lombard
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (5): 333–342.
https://doi.org/10.1042/CS20120232
Published: 16 November 2012
... in the arteries of SS rats. These findings indicate that SS rats have an up-regulation of the CYP4A/20-HETE pathway resulting in elevated ROS (reactive oxygen species) and reduced NO bioavailability causing vascular dysfunction. 20-hydroxyeicosatetraenoic acid (20-HETE) cytochrome P450 4A ω-hydroxylase...
View articletitled, Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5 BN consomic rats
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Articles

Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls

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Natalie C. Ward, Kevin D. Croft, David Blacker, Graeme J. Hankey, Anne Barden, Trevor A. Mori, Ian B. Puddey, Christopher D. Beer
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (11): 501–507.
https://doi.org/10.1042/CS20110215
Published: 09 August 2011
... Journal compilation © 2011 Biochemical Society 2011 acute ischaemic stroke arachidonic acid cytochrome P450 (CYP450) dihydroxyeicosatetraenoic acid (DiHETE) epoxyeicosatrienoic acid (EET) 20-hydroxyeicosatetraenoic acid (20-HETE) oxidative stress Ischaemic brain injury is thought...
View articletitled, Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls
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