...- hydroxycholecalciferol, glomerular filtration rate, 25-hydroxycholecalciferol, hyperparathyroidism. Abbreviations: cyclic AMP, adenosine 3':5'-cyclic mono- phosphate; GFR, glomerular filtration rate; iPTH, Correspondence: Dr B. C. Lalor, Department of Medicine, Royal Infirmary, Oxford Road, Manchester M13 9WL, UK...

... that extrarenal sites for the 26-hydroxylation of 25-hydroxycholecalciferol exist in man. 4. A strong positive correlation between the concentrations of 25-hydroxycholecalciferol and those of 25,26-dihydroxycholecalciferol in serum was obtained. Thus it appears that in man the production of this dihydroxy...

... clinical osteomalacia, and nine with serum 25–(OH)D > 25 nmol/l (30–125 nmol/l). 2. The concentrations in serum of radioactive cholecalciferol, 25–hydroxycholecalciferol (25–(OH)D 3 ) and the three dihydroxylated metabolites: 1,25–, 24,25– and 25,26–dihydroxycholecalciferol (1,25–(OH) 2 D 3 , 24,25-(OH...

...Carol M. Taylor; E. Barbara Mawer; Jayne E. Wallace; Judy St John; M. Cochran; R. G. G. Russell; J. A. Kanis 1. In subjects with normal renal function there was a strong positive correlation between serum concentrations of 25-hydroxycholecalciferol and 24,25-dihydroxycholecalciferol, as measured...

... (30·7 ± 9·9 ng/ml). 15 7 1976 © 1976 The Biochemical Society and the Medical Research Society 1976 assay bovine albumin 25-hydroxycholecalciferol Clinical Science and Molecular Medicine (1976) 51, 605-607. SHORT COMMUNICATION A competitive protein-binding assay for 25...

... and in patients with primary disorders of parathyroid function. 2. The formation of labelled 1,25-dihydroxycholecalciferol [1,25-(OH) 2 D 3 ] and labelled 24,25-dihydroxycholecalciferol [24,25-(OH) 2 D 3 ] has been related to the prevailing concentrations in serum of 25-hydroxycholecalciferol [25-(OH)D 3...

...S. Edelstein; M. Charman; D. E. M. Lawson; E. Kodicek 1. A competitive protein-binding assay for plasma 25-hydroxycholecalciferol was developed, using Sephadex LH-20 columns for the isolation of the sterol and a partially purified protein from rat serum as the binding protein. 2. The mean plasma 25...

...P. B. Greenberg; Carmel J. Hillyard; Leonora S. Galante; Kay W. Colston; Imogen M. A. Evans; I. MacIntyre 1. The affinity of cholecalciferol, ergocalciferol and 25-hydroxyergocalciferol for 25-hydroxycholecalciferol receptors in human, rat and chicken kidney cytosol fractions is related...

.... 4. Metabolically produced 25-hydroxycholecalciferol is also taken up from the blood into many tissues, probably by protein-binding. 5. Vitamin D is excreted in bile principally as more polar metabolites. Smaller amounts of cholecalciferol and 25-hydroxycholecalciferol are also excreted...