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Keywords: A-192621
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Articles
J. Ruth WU-WONG, Douglas B. DIXON, William J. CHIOU, Brian K. SORENSEN, Gang LIU, H.-S. JAE, Andrew TASKER, Thomas W. Von GELDERN, Martin WINN, Terry J. OPGENORTH
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 107S–111S.
Published: 01 September 2002
... their effects. Based on the same core structure, we have developed four small-molecule ET receptor antagonists, ABT-627, ABT-546, A-182086 and A-192621, which exhibit difference in selectivity for ET A and ET B receptors. In this report, we compare the potency and selectivity of these four antagonists...
Articles
Jerry L. WESSALE, Andrew L. ADLER, Eugene I. NOVOSAD, Samuel V. CALZADILLA, Brian D. DAYTON, Kennan C. MARSH, Martin WINN, Hwan-Soo JAE, Thomas W.von GELDERN, Terry J. OPGENORTH, J. Ruth WU-WONG
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 112S–117S.
Published: 01 September 2002
... A and ET B receptors to initiate their effects. Based on the same core structure, we have developed four small-molecule ET receptor antagonists, ABT-627 (atrasentan), ABT-546, A-182086 and A-192621, which exhibit differences in selectivity for ET A and ET B receptors. In this report, we compare...