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Keywords: AKI
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Articles

Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Riyaz Mohamed, Olga Rafikova, Paul M. O’Connor, Jennifer C. Sullivan
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1751–1762.
https://doi.org/10.1042/CS20200575
Published: 10 July 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 AKI HMGB1 inflammation kidney sex Renal ischemia is the most common cause of acute kidney injury (AKI), which has mortality rates as high as 80% in humans [ 1–3 ]. Patients that recover from...
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Articles

Urinary angiotensinogen as a biomarker for acute to chronic kidney injury transition – prognostic and mechanistic implications

Katie L. Connor, Laura Denby
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2383–2385.
https://doi.org/10.1042/CS20180795
Published: 13 November 2018
... Science (2018) 132 , 2121–2133], Cui et al. examine the ability of urinary angiotensinogen (uAGT) to predict the progression of acute kidney injury (AKI) to CKD. They principally employ a murine ischaemia reperfusion injury model to study this and provide data from a small prospective study of patients...
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Articles

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury

Yunwen Yang, Xiaowen Yu, Yue Zhang, Guixia Ding, Chunhua Zhu, Songming Huang, Zhanjun Jia, Aihua Zhang
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (7): 825–838.
https://doi.org/10.1042/CS20171625
Published: 16 April 2018
...Yunwen Yang; Xiaowen Yu; Yue Zhang; Guixia Ding; Chunhua Zhu; Songming Huang; Zhanjun Jia; Aihua Zhang Renal hypoxia occurs in acute kidney injury (AKI) of various etiologies. Activation of hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism of cellular...
View articletitled, Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury
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