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Keywords: AKT
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Clin Sci (Lond) (2021) 135 (21): 2483–2502.
Published: 08 November 2021
... (BMP2) and osteocalcin (OCN). These results were further confirmed in aortic rings ex vivo . Moreover, DMY ameliorated vascular calcification in rats with CKD. Additionally, we found that AKT signaling was activated during vascular calcification, whereas significantly inhibited by DMY administration...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (10): 1069–1073.
Published: 25 May 2018
... inhibtion of Akt (protein kinase B, PKB) signaling. We further discuss the mechanisms underlying Akt activation and its effects on CH and review possible mechanisms of leflunomide effects. Despite some caveats, the availability of such a newly repurposed compound to treat CH can be a relevant advance...
Clin Sci (Lond) (2018) 132 (6): 685–699.
Published: 30 March 2018
... of A77 1726 was not dependent on its T lymphocyte-inhibiting property. A77 1726 suppressed the activation of protein kinase B (AKT) signaling pathway, and overexpression of constitutively active AKT completely abolished A77 1726-mediated cardioprotective effects in vivo and in vitro . Pretreatment...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (3): 197–210.
Published: 05 January 2017
... on behalf of the Biochemical Society 2017 AKT phosphatase phosphoinositide 3-kinase (PI3K) prostate cancer Elevated and/or uncontrolled activation of the signalling networks activated by growth factors, in particular signalling through the phosphoinositide 3-kinase (PI3K) group of lipid...
Clin Sci (Lond) (2016) 130 (10): 813–828.
Published: 01 April 2016
... cardioprotective action by interruption of Akt- but not MAPK (mitogen-dependent protein kinase)-dependent signalling pathways. Additionally, inactivation of Akt by LY294002 offset the exacerbated hypertrophic response induced by AB in TRIM32-deficient mice. In conclusion, the present study indicates that TRIM32...
Clin Sci (Lond) (2015) 128 (12): 923–936.
Published: 27 March 2015
... mechanism analyses suggested that Vinexin-β exerted detrimental effects largely dependent on blocking AKT signalling. The effects and mechanisms of Vinexin-β on MI observed in vivo were further confirmed by our in vitro assays. When collected, these data demonstrate for the first time that Vinexin-β...