... groups was observed regarding oxidative stress markers. HbSS mice displayed a higher intramuscular acidosis during the ischemic period while their mitochondrial function was impaired as compared with their HbAA and HbAS counterparts. These metabolic abnormalities could worsen the complications related...

...Matthew L. P. HOWSE; Maureen LEONARD; Michael VENNING; Laurence SOLOMAN Metabolic acidosis frequently complicates end-stage renal failure. In haemodialysis patients its severity is usually monitored by measurement of the total CO 2 (TCO 2 ) level. Samples from ‘satellite dialysis’ patients...

...Daniel TETA; Alan BEVINGTON; Jeremy BROWN; David THROSSELL; Kevin P. G. HARRIS; John WALLS Marked hyperleptinaemia and metabolic acidosis are common findings in patients with chronic renal failure. In animal models, both leptin administration and acidosis reduce food intake. However, leptin causes...

... acidosis seems to be an important aetio-logical factor. 2. In uraemic patients abnormalities in blood amino acid profiles are present after a protein meal, suggesting impaired metabolism of ingested proteins. 3. This study demonstrates that acidosis induces changes in arterial amino acid profiles in fed...

...J. A. Lee; N. Shah; J. White; C. H. Orchard 1. We examined the effects of the novel thiadiazinone derivative EMD 57033 on developed force and intracellular [Ca 2+ ] in cardiac muscle during control conditions (pH 7.35) and in acidosis (pH 6.8). 2. In the control solution, application of EMD 57033...

...Sergio De Marchi; Emanuela Cecchin 1. To investigate mechanisms of extrarenal buffering in uraemic acidosis, we studied the effects of the carbonic anhydrase inhibitor, acetazolamide, in normal subjects and in patients with end-stage kidney disease on maintenance haemodialysis with virtually...

... acidosis in young SHR. 18 11 1987 17 12 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 acidosis ammonium ion bicarbonate hypertension titratable acid urinary pH Clinical Science (1988) 7S,29-34 29 Pathogenesis of abnormal acid-base balance...

...Norman L. M. Wong; Gary A. Quamme; John H. Dirks 1. Clearance and micropuncture studies were performed in four groups of acutely thyropara-thyroidectomized animals to study the effects of alkalosis and acidosis on the renal handling of magnesium. 2. Our results indicate that chronic metabolic...

... to the stimulatory effect of H + on the lactate carrier. 17 6 1985 23 7 1985 © 1986 The Biochemical Society and the Medical Research Society 1986 acidosis lactate liver pH Clinical Science (1986) 70, 19-22 19 Hepatic lactate uptake is enhanced by low pH at low lactate concentrations...

...Henri Lanctin; John T. Brosnan; Brian D. Ross 1. The possible involvement of renal glutamine synthesis in the regulation of ammoniagenesis during metabolic acidosis has been investigated. 2. Using an isotope dilution technique glutamine synthesis has been demonstrated in the intact perfused rat...

... and more so when, in addition, the perfusate was made acidic. 3. Hepatic ATP and ADP content increased in the presence of an acid perfusate. 4. It is concluded that both ischaemia and acidosis may contribute to the diminished hepatic uptake of lactic acid in strenuous exercise and shock. acidosis...

... bicarbonate and total ammonia than has been reported for faecal dialysate in normal subjects. 2. Total ammonia concentrations in urine– faeces specimens obtained by catheter suggest that urine excreted by the kidneys in these patients becomes increasingly acid with increasing systemic acidosis. The highly...

... skeletal buffering of non-volatile acids produced endogenously in nephrectomized rats. 25 7 1978 5 2 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 acidosis bone buffering colchicine diphosphonate intracellular pH Clinical Science (1979) 51,19-23...

...A. Fine; F. I. Bennett; G. A. O. Alleyne 1. The effects of acute acid—base alterations on renal ammonia production and glutamine metabolism were studied in anaesthetized dogs. 2. Plasma glutamine rose with acidosis and also when both P co 2 and plasma HCO − 3 were raised isohydrically. 3. Blood...

...A. Tizianello; G. De Ferrari; G. Gurreri; N. Acquarone 1. Whole-body intracellular pH (pH 1 ) was measured by the 14 C-labelled DMO method in twenty-four control subjects, eighteen normal subjects with induced acute metabolic alkalosis, ten normal subjects with induced acute metabolic acidosis...

... The Biochemical Society and the Medical Research Society 1976 acidosis ammonia gluconeogenesis glutamine kidney lactate mercaptopicolinate Clinical Science and Molecular Medicine (1976) 50, 493-498. Effect of inhibition of gluconeogenesis on ammonia production in the perfwed rat kidney B. D. ROSS N...

...M. Fulop 1. The ventilatory response to severe metabolic acidosis was studied by measuring arterial blood carbon dioxide tension and pH in sixty-seven patients with blood pH < 7·10, none of whom had hypercapnia, pulmonary oedema, or chronic pulmonary insufficiency. The results were compared...

...M. O. Farber; J. J. Szwed; A. R. Dowell; R. A. Strawbridge 1. Effective renal plasma flow, glomerular filtration rate and cardiac output were measured in osmotically loaded dogs before and during comparable acute respiratory and metabolic acidosis. 2. Urine output increased in control dogs...

... and the Medical Research Society 1976 acidosis gluconeogenesis kidney lactate Clinical Science and Molecular Medicine (1976) 50, 185-194. The effect of acidosis on lactate removal by the perfused rat kidney J. YUDKIN A N D R. D. COHEN The Metabolic and Endocrine and Medical Units, The London Hospital...

...J. Yudkin; R. D. Cohen; Barbara Slack 1. The effect of metabolic acidosis of 4–6 h duration on cardiac output, blood pressure, heart rate, and hepatic and renal blood flow has been studied in the rat. 2. In anaesthetized rats, blood pressure and heart rate fell linearly with blood pH in both sham...

...Jane Oliver; E. Bourke 1. The effects of oral hydrochloric acid, ammonium chloride, sodium bicarbonate and ammonium bicarbonate on urea and ammonium excretion in rats on a constant diet were studied. 2. Hydrochloric acid acidosis significantly reduced urea excretion in the rat, with an equimolar...

... of acidosis. No such effect is seen in sham-operated animals. 4. An increase in the ability of the kidney to remove lactate during acidosis compensates for approximately half of the simultaneous fall in the capacity of the remainder of the body for lactate assimilation. 5. Basal blood lactate concentrations...

...M. Fulop; N. Dreyer; H. Tannenbaum 1. Previous studies of the ventilatory response to metabolic acidosis have usually considered only patients with arterial blood pH above 7·10. To define the response during more severe acidaemia, arterial CO 2 tension and pH were measured in fifty-three episodes...

...M. H. Lloyd; R. A. Iles; B. R. Simpson; J. M. Strunin; J. M. Layton; R. D. Cohen 1. The relationship between extracellular pH (pH e ), intracellular pH (pH i ) and lactate uptake was studied in the isolated perfused rat liver during simulated metabolic acidosis. 2. pH i fell to a considerably less...

... were studied. 2. Acute acidosis (pH 7·21) resulted in a small rise in pulmonary artery pressure, cardiac output and pulmonary vascular resistance, associated with a decrease in P a,co 2 . Acute alkalosis (pH 7·61) was accompanied by a small rise in pulmonary artery pressure, marked increase in cardiac...