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Keywords: Actin
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Articles
Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction
Available to PurchaseThomas Jansson, Marisol Castillo-Castrejon, Madhulika B. Gupta, Theresa L. Powell, Fredrick J. Rosario
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (1): 53–70.
Published: 10 January 2020
... (AAT) isoforms to the ST plasma membrane; however, the molecular mechanisms are unknown. Cdc42 and Rac1 are Rho-GTPases that regulate actin-binding proteins, thereby modulating the structure and dynamics of the actin cytoskeleton. We hypothesized that inhibition of mTORC2 decreases AAT expression...
Includes: Supplementary data
