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Keywords: Acute kidney injury
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (22): 1451–1466.
Published: 15 November 2024
...Ting-Ting Chang; Szu-Yuan Li; Ming-Tsun Tsai; Chih-Hung Chiang; Ching Chen; Jaw-Wen Chen Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD). CXC motif chemokine ligand 5 (CXCL5) is up-regulated in kidney diseases. We aimed to investigate the direct effect of CXCL5...
Includes: Supplementary data
Articles
Wei Gong, Lingling Lu, Haoyang Ma, Mingfeng Shan, Xinwen Fan, Mi Bai, Yue Zhang, Songming Huang, Zhanjun Jia, Aihua Zhang
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (13): 777–795.
Published: 21 June 2024
...Wei Gong; Lingling Lu; Haoyang Ma; Mingfeng Shan; Xinwen Fan; Mi Bai; Yue Zhang; Songming Huang; Zhanjun Jia; Aihua Zhang Renal tubular injury is considered as the main pathological feature of acute kidney injury (AKI), and mitochondrial dysfunction in renal tubular cells is implicated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (10): 599–614.
Published: 22 May 2024
...Adrianna Douvris; Jose L. Viñas; Alexey Gutsol; Joseph Zimpelmann; Dylan Burger; Kevin D. Burns Aim: Acute kidney injury (AKI) increases the risk for progressive chronic kidney disease (CKD). MicroRNA (miR)-486-5p protects against kidney ischemia–reperfusion (IR) injury in mice, although its long...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (6): 351–369.
Published: 12 March 2024
...Ying Fu; Yu Xiang; Jie Zha; Guochun Chen; Zheng Dong Septic acute kidney injury (AKI) is a severe form of renal dysfunction associated with high morbidity and mortality rates. However, the pathophysiological mechanisms underlying septic AKI remain incompletely understood. Herein, we investigated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (5): 309–326.
Published: 05 March 2024
...Gregory H. Tesch; Frank Y. Ma; Elyce Ozols; David J. Nikolic-Paterson Senescence of kidney tubules leads to tubulointerstitial fibrosis (TIF). Proximal tubular epithelial cells undergo stress-induced senescence during diabetes and episodes of acute kidney injury (AKI), and combining these injuries...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (5): 235–249.
Published: 27 February 2024
...Zhongqiang Zhu; Jun Li; Zhiyong Song; Tonglu Li; Zongping Li; Xuezhong Gong Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI). Recently, ferroptosis was reported to be crucial for AKI pathogenesis. Our previous studies indicated antioxidant...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (10): 843–846.
Published: 31 May 2023
...Riyaz Mohamed; Michael J. Ryan Acute kidney injury (AKI) remains a significant clinical problem with a high mortality rate. Thus, the need for early recognition and treatment of AKI is an important goal. Clinical Science has a history of publishing high impact work across a breadth of scientific...
Articles
Lingling Lu, Weihua Liu, Shumin Li, Mi Bai, Yu Zhou, Zhaohui Jiang, Zhanjun Jia, Songming Huang, Aihua Zhang, Wei Gong
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (6): 435–452.
Published: 21 March 2023
... vascular disrupting agent and known as an agonist of STING. Although cGAS-STING activation has been demonstrated to mediate cisplatin-induced acute kidney injury (AKI), the role of DMXAA in this condition is unclear. Here, we defined an unexpected and critical role of DMXAA in improving renal function...
Includes: Supplementary data
Articles
Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 47–63.
Published: 05 January 2023
...Nada J. Habeichi; Rana Ghali; Ali Mroueh; Abdullah Kaplan; Cynthia Tannous; Abdo Jurjus; Ghadir Amin; Mathias Mericskay; George W. Booz; Ahmed El-Yazbi; Fouad A. Zouein Acute kidney injury (AKI) is a common complication of cardiovascular diseases (CVDs) in both males and females, increasing...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
...Honglin Li; Zhiwen Liu; Ying Wang; Hui Wang; Juan Cai; Chengyuan Tang; Zheng Dong Sepsis is a leading cause of acute kidney injury (AKI), and the pathogenesis of septic AKI remains largely unclear. Parkinson disease protein 7 (PARK7) is a protein of multiple functions that was recently implicated...
Articles
Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (11): 825–840.
Published: 01 June 2022
...Riyaz Mohamed; Gene R. Crislip; Sarah McLarnon; Qingqing Wei; Paul M. O’Connor; Jennifer C. Sullivan Acute kidney injury (AKI) due to ischemia is a serious and frequent clinical complication with mortality rates as high as 80%. Vascular congestion in the renal outer medulla occurs early after...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2607–2618.
Published: 08 December 2021
...Laurie Bruzzese; Gwénaël Lumet; Donato Vairo; Claire Guiol; Régis Guieu; Alice Faure Ischaemia–reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and chronic kidney disease, which consists of cellular damage and renal dysfunction. AKI is a major complication...
Articles
Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
..., the increased concentration of vasoconstrictor mediators together with the preservation (and even increase) of the response to them may help to explain sepsis-induced acute kidney injury. Correspondence: Jamil Assreuy ( [email protected] ) 11 05 2021 24 09 2021 07 10 2021 08 10...
Articles
Tatiane Cristine Silva de Almeida, Katharina Lanza, Roberta da Silva Filha, Leda Maria de Castro C. Campos, Esdras G. Fonseca, Mariana W. Chagas, Natalia Pessoa Rocha, Marcos Augusto de Sá, Maria Aparecida Ribeiro Vieira, Marcelo Vidigal Caliari, Lucas M. Kangussu, Anderson José Ferreira, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3093–3106.
Published: 02 December 2020
... Cristina Simões e Silva Acute Kidney Injury (AKI) comprises a rapidly developed renal failure and is associated with high mortality rates. The Renin–Angiotensin System (RAS) plays a pivotal role in AKI, as the over-active RAS axis exerts major deleterious effects in disease progression. In this sense...
Articles
miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute tubular injury
Wenjuan Yu, Honghui Zeng, Junzhe Chen, Sha Fu, Qiuyan Huang, Yanchun Xu, Anping Xu, Hui-yao Lan, Ying Tang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2223–2234.
Published: 28 August 2020
... and vascular rarefaction. Mechanistically, the protective effect of miR-20a-5p on acute kidney injury (AKI) was associated with inhibition of TECs mitochondrial injury and apoptosis in vitro and in vivo . In conclusion, miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
Articles
Jose L. Viñas, Christopher J. Porter, Adrianna Douvris, Matthew Spence, Alex Gutsol, Joseph A. Zimpelmann, Karishma Tailor, Pearl A. Campbell, Kevin D. Burns
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1887–1909.
Published: 23 July 2020
...Jose L. Viñas; Christopher J. Porter; Adrianna Douvris; Matthew Spence; Alex Gutsol; Joseph A. Zimpelmann; Karishma Tailor; Pearl A. Campbell; Kevin D. Burns Female sex protects against development of acute kidney injury (AKI). While sex hormones may be involved in protection, the role...
Includes: Supplementary data
Articles
Chia-Lin Wu, Chia-Chu Chang, Tao-Hsiang Yang, Alexander Charng-Dar Tsai, Jui-Lin Wang, Chung-Ho Chang, Der-Cherng Tarng
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1593–1612.
Published: 30 June 2020
... in tubular epithelial cells, are not well-known. To elucidate the adaptive expression, protective effects on kidney injury, and signaling pathways of TAZ in response to acute kidney injury (AKI), we used in vitro (hypoxia-treated human renal proximal tubular epithelial cells [RPTECs]) and in vivo (mouse...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 139–154.
Published: 23 January 2020
...Yiling Cao; Xuhua Mi; Dongmei Zhang; Zheng Wang; Yongdi Zuo; Wanxin Tang Acute kidney injury (AKI) is a common serious syndrome characterized by rapid decrease of glomerular filtration rate and the progressive increase of serum creatinine. Circular RNAs (circRNAs) are regulatory RNAs that recently...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1031–1047.
Published: 02 May 2019
...Hitesh Soni; Dieniffer Peixoto-Neves; Michael A. Olushoga; Adebowale Adebiyi Renal vasoconstriction, an early manifestation of ischemic acute kidney injury (AKI), results in renal hypoperfusion and a rapid decline in kidney function. The pathophysiological mechanisms that underlie ischemia...
Includes: Supplementary data
Articles
In Collection
Clinical and translational research highlights
Shuang Cui, Liling Wu, Xiaodan Feng, Huanjuan Su, Zhanmei Zhou, Weihong Luo, Cailing Su, Yajing Li, Meng Shi, Zhichen Yang, Wei Cao
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2121–2133.
Published: 05 October 2018
.... Correspondence: Wei Cao ( [email protected] ) * These authors contributed equally to this work. 28 08 2018 11 09 2018 17 09 2018 17 09 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 acute kidney injury chronic...
Includes: Supplementary data
Articles
Junhui Shen, Zhong-Kai Cui, Fang Yao, Kai Li, Yue Zhang, Zhenguo Chen, Yuxia Zhou, Song Xu, Yuwei Zhang, Wenqing Jiang, Hanbin Zhang, Kaifen Tan, Anling Liu, Xiaochun Bai
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... on behalf of the Biochemical Society 2018 acute kidney injury endothelin-1 fibroblast mTORC1 sepsis TSC1 Sepsis, a dysregulated host response to severe infection [ 1 ], has been shown to occur in 32.4–47.5% of critically ill patients with acute kidney injury (AKI). It is associated...
Includes: Supplementary data
Articles
Magaiver Andrade-Silva, Marcos Antonio Cenedeze, Luiz Augusto Perandini, Raphael José Ferreira Felizardo, Ingrid Kazue Mizuno Watanabe, Juan Sebastian Henao Agudelo, Angela Castoldi, Giselle Martins Gonçalves, Clarice Silvia Taemi Origassa, Patricia Semedo, Meire Ioshie Hiyane, Orestes Foresto-Neto, Denise Maria Avancini Costa Malheiros, Marlene Antonia Reis, Clarice Kazue Fujihara, Roberto Zatz, Alvaro Pacheco-Silva, Niels Olsen Saraiva Câmara, Danilo Candido de Almeida
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1725–1739.
Published: 22 August 2018
...; Denise Maria Avancini Costa Malheiros; Marlene Antonia Reis; Clarice Kazue Fujihara; Roberto Zatz; Alvaro Pacheco-Silva; Niels Olsen Saraiva Câmara; Danilo Candido de Almeida Acute kidney injury (AKI) is considered an inflammatory disease in which toll-like receptors (TLRs) signaling pathways play...
Includes: Supplementary data
Articles
Jinhua Tang, Yingfeng Shi, Na Liu, Liuqing Xu, Xiujuan Zang, Peibin Li, Juanlian Zhang, Xiaoqing Zheng, Andong Qiu, Shougang Zhuang
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (3): 339–359.
Published: 02 February 2018
... side effects, for instance bone marrow suppression and nephrotoxicity. In the present study, we utilized a murine model of cisplatin-induced acute kidney injury (AKI) and a highly selective inhibitor of HDAC6, tubastatin A (TA), to assess the role of HDAC6 in nephrotoxicity and its associated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1955–1969.
Published: 13 July 2017
...Sha Fu; Ying Tang; Xiao R. Huang; Min Feng; An P. Xu; Hui Y. Lan Smad7 plays a protective role in chronic kidney disease; however, its role in acute kidney injury (AKI) remains unexplored. Here, we report that Smad7 protects against AKI by rescuing the G1 cell cycle arrest of tubular epithelial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1617–1629.
Published: 30 June 2017
... ]. Correspondence: Alberto Ortiz ( [email protected] ) 09 01 2017 06 04 2017 07 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 acute kidney injury chronic kidney disease implementation patient outcomes prevention...
Articles
Jing Xu, Pei-Xue Li, Jun Wu, Yi-Jun Gao, Meng-Xin Yin, Ye Lin, Ming Yang, Dong-Ping Chen, Hai-Peng Sun, Zeng-Bo Liu, Xiang-Chen Gu, Hong-Ling Huang, Li-Li Fu, Hui-Min Hu, Liang-Liang He, Wen-Qing Wu, Zhao-Liang Fei, Hong-Bin Ji, Lei Zhang, Chang-Lin Mei
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (5): 349–363.
Published: 26 January 2016
... they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
... medicine after renal injury. Correspondence : Dr Anton J.M. Roks (email [email protected] ) 26 1 2015 27 1 2015 27 1 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 acute kidney injury bone marrow renin–angiotensin system Stem...
Articles
Esko Kankuri, Elina E. Mervaala, Markus Storvik, Aija M.J. Ahola, Jouko Levijoki, Dominik N. Müller, Piet Finckenberg, Eero M. Mervaala
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 735–747.
Published: 17 March 2015
...Esko Kankuri; Elina E. Mervaala; Markus Storvik; Aija M.J. Ahola; Jouko Levijoki; Dominik N. Müller; Piet Finckenberg; Eero M. Mervaala Hypertension and persistent activation of the renin–angiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although...
Articles
Kátia D. da Silveira, Kênia S. Pompermayer Bosco, Lúcio R. L. Diniz, Adriana K. Carmona, Giovanni D. Cassali, Oscar Bruna-Romero, Lirlândia P. de Sousa, Mauro M. Teixeira, Robson A. S. Santos, Ana C. Simões e Silva, Maria A. Ribeiro Vieira
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (9): 385–394.
Published: 23 July 2010
... enzyme) and the AT 1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor...
