... of the Biochemical Society 2024 Alzheimer's disease blood brain barrier Neurodegenerative disease ScRNA-seq Spinal muscular atrophy Vascular defects National Natural Science Foundation of China 32000841 National Natural Science Foundation of China 32200940 Large Instruments Open...

...Ezekiel Gonzalez-Fernandez; Yedan Liu; Alexander P. Auchus; Fan Fan; Richard J. Roman The accumulation of extracellular amyloid-β (Aβ) and intracellular hyperphosphorylated τ proteins in the brain are the hallmarks of Alzheimer’s disease (AD). Much of the research into the pathogenesis of AD has...

... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke Regarding ACE2, ACE2 is widespread...

... investigational pipeline of treatment options for this important disease area. The authors declare that there are no competing interests associated with the manuscript. AD Alzheimer's disease CSF, cerebrospinal fluid; CVD cerebrovascular disease EM experimental medicine FDG...

...H.K. Irundika Dias; Caroline L.R. Brown; M. Cristina Polidori; Gregory Y.H. Lip; Helen R. Griffiths Elevated low-density lipoprotein (LDL) concentration in mid-life increases the risk of developing Alzheimer's disease (AD) in later life. Increased oxidized LDL (oxLDL) modification and nitration...

... and the data presented as a ratio relative to non-treated cells as described previously [ 34 ]. Alzheimer's disease amyloid β-peptide amyloid precursor protein extracellular-signal-regulated kinase (ERK) glycosphingolipid Amyloid plaques are a key pathological feature of AD (Alzheimer's...

... reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory...

.../infection [ 60 ]. Correspondence: Dr Tammy Kielian (email [email protected] ). 29 3 2011 13 5 2011 16 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease bacterial meningitis central nervous system learning and memory...

... permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. aging Alzheimer's disease atherosclerosis heart failure longevity Parkinson's disease telomerase telomere The 2009 Nobel Prize in Physiology or Medicine...

...Robin Altman; John C. Rutledge AD (Alzheimer's disease) is a progressive neurodegenerative disease of unknown origin. Despite questions as to the underlying cause(s) of this disease, shared risk factors for both AD and atherosclerotic cardiovascular disease indicate that vascular mechanisms may...

...Christopher C. T. Smith; Lee Stanyer; D. John Betteridge; Michael B. Cooper Cerebrovascular accumulation of Aβ (β-amyloid) occurs in aging and AD (Alzheimer's disease). Hypercholesterolaemia, which is associated with raised plasma LDL (low-density lipoprotein), may predispose to AD. Soluble Aβ...

... disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins, BDNF is secreted in an activity-dependent manner that allows the highly...