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Keywords: Alzheimer's disease
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Articles
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... levels [ 74 ] Human ↑ AT1R [ 74 ] Hypertensive (mRen2)27 transgenic rats ↑ Ang II levels [ 82 ] Alzheimer’s disease Human ↑ ACE expression and activity [ 64–67 ] Human ↓ ACE2 activity in mid-frontal cortex [ 69 ] Human ↑ Ang II levels in mid-frontal cortex [ 69 ] Human...
Articles
Clin Sci (Lond) (2017) 131 (9): 799–802.
Published: 19 April 2017
.... Correspondence: Paul B. Wren ( paul-bryan.b.wren@gsk.com ) 7 12 2016 6 2 2017 9 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 Alzheimer's disease cerebrovascular disease dementia drug discovery translational science...
Articles
Clin Sci (Lond) (2015) 129 (12): 1195–1206.
Published: 11 November 2015
...H.K. Irundika Dias; Caroline L.R. Brown; M. Cristina Polidori; Gregory Y.H. Lip; Helen R. Griffiths Elevated low-density lipoprotein (LDL) concentration in mid-life increases the risk of developing Alzheimer's disease (AD) in later life. Increased oxidized LDL (oxLDL) modification and nitration is...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 122 (9): 409–420.
Published: 16 January 2012
... is properly cited. Alzheimer's disease amyloid β-peptide amyloid precursor protein extracellular-signal-regulated kinase (ERK) glycosphingolipid Amyloid plaques are a key pathological feature of AD (Alzheimer's disease) [ 1 ], a common neurodegenerative disorder affecting our aging...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 122 (7): 323–328.
Published: 07 December 2011
... reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory...
Articles
Clin Sci (Lond) (2011) 121 (9): 367–387.
Published: 12 July 2011
... (email tkielian@unmc.edu ). 29 3 2011 13 5 2011 16 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease bacterial meningitis central nervous system learning and memory neurogenesis Toll-like receptor Innate immunity...
Articles
Clin Sci (Lond) (2011) 120 (10): 427–440.
Published: 28 January 2011
... permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. aging Alzheimer's disease atherosclerosis heart failure longevity Parkinson's disease telomerase telomere The 2009 Nobel Prize in Physiology or Medicine...
Articles
Clin Sci (Lond) (2010) 119 (10): 407–421.
Published: 05 August 2010
...Robin Altman; John C. Rutledge AD (Alzheimer's disease) is a progressive neurodegenerative disease of unknown origin. Despite questions as to the underlying cause(s) of this disease, shared risk factors for both AD and atherosclerotic cardiovascular disease indicate that vascular mechanisms may...
Articles
Clin Sci (Lond) (2007) 113 (11): 427–434.
Published: 01 November 2007
...Christopher C. T. Smith; Lee Stanyer; D. John Betteridge; Michael B. Cooper Cerebrovascular accumulation of Aβ (β-amyloid) occurs in aging and AD (Alzheimer's disease). Hypercholesterolaemia, which is associated with raised plasma LDL (low-density lipoprotein), may predispose to AD. Soluble Aβ is...
Articles
Clin Sci (Lond) (2006) 110 (2): 175–191.
Published: 17 January 2006
... disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins, BDNF is secreted in an activity-dependent manner that allows the highly...