Page 1 | Search Results | Clinical Science

1-50 of 102

Sort by

Sort Order Select

Articles

Fifty years of research on the brain renin–angiotensin system: what have we learned?

Edwyn O. Cruz-López, Estrellita Uijl, A.H. Jan Danser

Clin Sci (Lond) (2021) 135 (14): 1727–1731.

https://doi.org/10.1042/CS20210579

Published: 22 July 2021

...Edwyn O. Cruz-López; Estrellita Uijl; A.H. Jan Danser Although the existence of a brain renin–angiotensin system (RAS) had been proposed five decades ago, we still struggle to understand how it functions. The main reason for this is the virtual lack of renin at brain tissue sites. Moreover...

View articletitled, Fifty years of research on the brain renin–angiotensin system: what have we learned?

Articles

Brain angiotensin suppression in the DOCA-salt model: reversal by angiotensinogen small interfering RNA?

Estrellita Uijl, A.H. Jan Danser

Clin Sci (Lond) (2021) 135 (7): 885–886.

https://doi.org/10.1042/CS20210199

Published: 09 April 2021

...Estrellita Uijl; A.H. Jan Danser Correspondence: A.H. Jan Danser ( [email protected] ) 21 02 2021 22 03 2021 29 03 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 angiotensin angiotensinogen brain...

View articletitled, Brain angiotensin suppression in the DOCA-salt model: reversal by angiotensinogen small interfering RNA?

Articles

Brain angiotensin system: a new promise in the management of epilepsy?

Alberto Javier Ramos

Clin Sci (Lond) (2021) 135 (6): 725–730.

https://doi.org/10.1042/CS20201296

Published: 17 March 2021

...Alberto Javier Ramos Epilepsy is a highly prevalent neurological disease and anti-epileptic drugs (AED) are almost the unique clinical treatment option. A disbalanced brain renin–angiotensin system (RAS) has been proposed in epilepsy and several reports have shown that angiotensin II (Ang II...

View articletitled, Brain angiotensin system: a new promise in the management of epilepsy?

Articles

Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19

In Collection

Coronavirus

Maria A. Pedrosa, Rita Valenzuela, Pablo Garrido-Gil, Carmen M. Labandeira, Gemma Navarro, Rafael Franco, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez

Clin Sci (Lond) (2021) 135 (3): 465–481.

https://doi.org/10.1042/CS20201511

Published: 01 February 2021

...Maria A. Pedrosa; Rita Valenzuela; Pablo Garrido-Gil; Carmen M. Labandeira; Gemma Navarro; Rafael Franco; Jose L. Labandeira-Garcia; Ana I. Rodriguez-Perez The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-converting enzyme 2), which acts as a double-edged sword...

View articletitled, Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19

Includes: Supplementary data

Articles

ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19

In Collection

Coronavirus

Rhian M. Touyz, Hongliang Li, Christian Delles

Clin Sci (Lond) (2020) 134 (7): 747–750.

https://doi.org/10.1042/CS20200363

Published: 07 April 2020

...Rhian M. Touyz; Hongliang Li; Christian Delles Angiotensin converting enzyme 2 (ACE2) is the major enzyme responsible for conversion of Ang II into Ang-(1-7). It also acts as the receptor for severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2, which causes Co rona vi rus D isease (COVID...

View articletitled, ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19

Articles

Rho kinase activation in circulating leukocytes is related to hypertensive myocardial remodeling

Maria P. Ocaranza, Camila Fierro, Jorge E. Jalil, Jackeline Moya, Leticia Gonzalez, Cristián Molina, Cristián Mancilla

Clin Sci (Lond) (2018) 132 (16): 1837–1853.

https://doi.org/10.1042/CS20180312

Published: 30 August 2018

... was considered as statistically significant. angiotensin ERM hypertension MYPT1 Rho kinase reverse remodeling Asymptomatic organ damage due to cardiovascular remodeling and continuing kidney damage put hypertensive patients at high risk for developing heart and renal failure, stroke...

View articletitled, Rho kinase activation in circulating leukocytes is related to hypertensive myocardial remodeling

Includes: Supplementary data

Articles

Neuroprotection via AT 2 receptor agonists in ischemic stroke

Douglas M. Bennion, U. Muscha Steckelings, Colin Sumners

Clin Sci (Lond) (2018) 132 (10): 1055–1067.

https://doi.org/10.1042/CS20171549

Published: 25 May 2018

.... Consequently, there remains a need for agents that will protect neurones against death following ischemic stroke. Here, we evaluate angiotensin II (Ang II) type 2 (AT 2 ) receptor agonists as a possible therapeutic target for this disease. We first provide an overview of stroke epidemiology, pathophysiology...

View articletitled, Neuroprotection via AT 2 receptor agonists in ischemic stroke

Articles

Angiotensin generation in the brain: a re-evaluation

Estrellita Uijl, Liwei Ren, A.H. Jan Danser

Clin Sci (Lond) (2018) 132 (8): 839–850.

https://doi.org/10.1042/CS20180236

Published: 30 April 2018

...Estrellita Uijl; Liwei Ren; A.H. Jan Danser The existence of a so-called brain renin-angiotensin system (RAS) is controversial. Given the presence of the blood–brain barrier, angiotensin generation in the brain, if occurring, should depend on local synthesis of renin and angiotensinogen. Yet...

View articletitled, Angiotensin generation in the brain: a re-evaluation

Articles

Protective effects of the angiotensin II AT 2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach

Douglas M. Bennion, Chad H. Jones, Alex N. Dang, Jacob Isenberg, Justin T. Graham, Lena Lindblad, Oliver Domenig, Michael F. Waters, Marko Poglitsch, Colin Sumners, Ulrike Muscha Steckelings

Clin Sci (Lond) (2018) 132 (5): 581–593.

https://doi.org/10.1042/CS20180100

Published: 15 March 2018

...Douglas M. Bennion; Chad H. Jones; Alex N. Dang; Jacob Isenberg; Justin T. Graham; Lena Lindblad; Oliver Domenig; Michael F. Waters; Marko Poglitsch; Colin Sumners; Ulrike Muscha Steckelings Significant neuroprotective effects of angiotensin II type 2 (AT 2 ) receptor (AT 2 receptor) agonists...

View articletitled, Protective effects of the angiotensin II AT 2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach

Articles

AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice

Friedrich Krueger, Kai Kappert, Anna Foryst-Ludwig, Frederike Kramer, Markus Clemenz, Aleksandra Grzesiak, Manuela Sommerfeld, Jan Paul Frese, Andreas Greiner, Ulrich Kintscher, Thomas Unger, Elena Kaschina

Clin Sci (Lond) (2017) 131 (15): 1989–2005.

https://doi.org/10.1042/CS20170131

Published: 13 July 2017

...Friedrich Krueger; Kai Kappert; Anna Foryst-Ludwig; Frederike Kramer; Markus Clemenz; Aleksandra Grzesiak; Manuela Sommerfeld; Jan Paul Frese; Andreas Greiner; Ulrich Kintscher; Thomas Unger; Elena Kaschina The renin–angiotensin system (RAS) and obesity have been implicated in vascular outward...

View articletitled, AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice

Articles

T-cell involvement in sex differences in blood pressure control

G. Ryan Crislip, Jennifer C. Sullivan

Clin Sci (Lond) (2016) 130 (10): 773–783.

https://doi.org/10.1042/CS20150620

Published: 01 April 2016

... of this article is to review the available literature regarding sex differences in T-cells in hypertension followed by highlighting the potential pathways that may result in sex-specific effects on T-cell activation and differentiation. angiotensin blood pressure regulation inflammation sex differences...

View articletitled, T-cell involvement in sex differences in blood pressure control

Articles

Angiotensin-(1–7) and angiotensin-(1–9): function in cardiac and vascular remodelling

Clare A. McKinney, Caroline Fattah, Christopher M. Loughrey, Graeme Milligan, Stuart A. Nicklin

Clin Sci (Lond) (2014) 126 (12): 815–827.

https://doi.org/10.1042/CS20130436

Published: 26 February 2014

...Clare A. McKinney; Caroline Fattah; Christopher M. Loughrey; Graeme Milligan; Stuart A. Nicklin The RAS (renin–angiotensin system) is integral to cardiovascular physiology; however, dysregulation of this system largely contributes to the pathophysiology of CVD (cardiovascular disease). It is well...

View articletitled, Angiotensin-(1–7) and angiotensin-(1–9): function in cardiac and vascular remodelling

Articles

Cerebroprotective action of angiotensin peptides in stroke

Robert W. Regenhardt, Douglas M. Bennion, Colin Sumners

Clin Sci (Lond) (2014) 126 (3): 195–205.

https://doi.org/10.1042/CS20130324

Published: 01 October 2013

...Robert W. Regenhardt; Douglas M. Bennion; Colin Sumners The goal of the present review is to examine the evidence for beneficial actions of manipulation of the RAS (renin–angiotensin system) in stroke, with particular focus on Ang-(1–7) [angiotensin-(1–7)] and its receptor Mas. The RAS appears...

View articletitled, Cerebroprotective action of angiotensin peptides in stroke

Articles

Involvement of the renin–angiotensin system in abdominal and thoracic aortic aneurysms

Hong Lu, Debra L. Rateri, Dennis Bruemmer, Lisa A. Cassis, Alan Daugherty

Clin Sci (Lond) (2012) 123 (9): 531–543.

https://doi.org/10.1042/CS20120097

Published: 13 July 2012

... diseases in humans that appear to have distinct pathologies and mechanisms. Despite this divergence, there are numerous and consistent demonstrations that overactivation of the RAS (renin–angiotensin system) promotes both AAAs and TAAs in animal models. For example, in mice, both AAAs and TAAs are formed...

View articletitled, Involvement of the renin–angiotensin system in abdominal and thoracic aortic aneurysms

Articles

Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes

Chris Tikellis, Raelene Pickering, Despina Tsorotes, Xiao-Jun Du, Helen Kiriazis, Thu-Phuc Nguyen-Huu, Geoffrey A. Head, Mark E. Cooper, Merlin C. Thomas

Clin Sci (Lond) (2012) 123 (8): 519–529.

https://doi.org/10.1042/CS20110668

Published: 03 July 2012

...Chris Tikellis; Raelene Pickering; Despina Tsorotes; Xiao-Jun Du; Helen Kiriazis; Thu-Phuc Nguyen-Huu; Geoffrey A. Head; Mark E. Cooper; Merlin C. Thomas Local and systemic AngII (angiotensin II) levels are regulated by ACE2 (angiotensin-converting enzyme 2), which is reduced in diabetic tissues...

View articletitled, Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes

Includes: Supplementary data

Articles

Angiotensin-(1–7) in kidney disease: a review of the controversies

Danielle Zimmerman, Kevin D. Burns

Clin Sci (Lond) (2012) 123 (6): 333–346.

https://doi.org/10.1042/CS20120111

Published: 29 May 2012

...Danielle Zimmerman; Kevin D. Burns Ang-(1–7) [angiotensin-(1–7)] is a biologically active heptapeptide component of the RAS (renin–angiotensin system), and is generated in the kidney at relatively high levels, via enzymatic pathways that include ACE2 (angiotensin-converting enzyme 2...

View articletitled, Angiotensin-(1–7) in kidney disease: a review of the controversies

Articles

The renin–angiotensin system, bone marrow and progenitor cells

Matej Durik, Bruno Sevá Pessôa, Anton J. M. Roks

Clin Sci (Lond) (2012) 123 (4): 205–223.

https://doi.org/10.1042/CS20110660

Published: 24 April 2012

...Matej Durik; Bruno Sevá Pessôa; Anton J. M. Roks Modulation of the RAS (renin–angiotensin system), in particular of the function of the hormones AngII (angiotensin II) and Ang-(1–7) [angiotensin-(1–7)], is an important target for pharmacotherapy in the cardiovascular system. In the classical view...

View articletitled, The renin–angiotensin system, bone marrow and progenitor cells

Articles

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE −/− mice

Alan Daugherty, Debra L. Rateri, Israel F. Charo, A. Phillip Owens, III, Deborah A. Howatt, Lisa A. Cassis

Clin Sci (Lond) (2010) 118 (11): 681–689.

https://doi.org/10.1042/CS20090372

Published: 09 March 2010

...Alan Daugherty; Debra L. Rateri; Israel F. Charo; A. Phillip Owens, III; Deborah A. Howatt; Lisa A. Cassis AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multiple proposed mechanisms, including chemotaxis. Therefore, we determined the effects of whole...

View articletitled, Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE −/− mice

Articles

The role of the renin–angiotensin–aldosterone system in cardiovascular progenitor cell function

Cheng Qian, Regien G. Schoemaker, Wiek H. van Gilst, Anton J. M. Roks

Clin Sci (Lond) (2009) 116 (4): 301–314.

https://doi.org/10.1042/CS20080157

Published: 15 January 2009

...Cheng Qian; Regien G. Schoemaker; Wiek H. van Gilst; Anton J. M. Roks Intervention in the RAAS (renin–angiotensin–aldosterone system) is one of the leading pharmacotherapeutic strategies, among others, used for the treatment of cardiovascular disease to improve the prognosis after myocardial...

View articletitled, The role of the renin–angiotensin–aldosterone system in cardiovascular progenitor cell function

Articles

Renin–angiotensin vaccine: old story, new project ‘efficacy versus safety’

Jean-Baptiste MICHEL

Clin Sci (Lond) (2004) 107 (2): 145–147.

https://doi.org/10.1042/CS20040116

Published: 27 July 2004

...Jean-Baptiste MICHEL In the present issue of Clinical Science , Brown and co-workers report preliminary results of Ang I (angiotensin I) immunization in humans. They demonstrate the presence of antibodies in human plasma and report that the procedure is well tolerated, but the blood pressure does...

View articletitled, Renin–angiotensin vaccine: old story, new project ‘efficacy versus safety’

Articles

Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects

Morris J. BROWN, John COLTART, Kulasiri GUNEWARDENA, James M. RITTER, Timothy R. AUTON, James F. GLOVER

Clin Sci (Lond) (2004) 107 (2): 167–173.

https://doi.org/10.1042/CS20030381

Published: 27 July 2004

...Morris J. BROWN; John COLTART; Kulasiri GUNEWARDENA; James M. RITTER; Timothy R. AUTON; James F. GLOVER Immunization against components of the renin–angiotensin system offers a potential alternative to daily medication in some patients with hypertension or heart failure. Our primary objective...

View articletitled, Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects

Articles

Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats

Bruno BATTISTINI, Bilal AYACH, Stéphanie MOLEZ, Andre BLOUIN, Arco Y. JENG

Clin Sci (Lond) (2002) 103 (s2002): 363S–366S.

https://doi.org/10.1042/CS103S363S

Published: 01 September 2002

... rats and spontaneously hypertensive rats (SHRs). At that dose, the magnitude of the antihypertensive effects was greater in SHRs than in normotensive rats. Additional administration of an angiotensin-converting enzyme (ACE) inhibitor benazapril (lotensin) further reduced MABP in normotensive rats...

View articletitled, Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats

Articles

Angiotensinogen M235T gene polymorphism and recurrent restenosis after repeated percutaneous transluminal coronary angiography

Sabine HERTWIG, Henry VÖLZKE, Daniel M. ROBINSON, Wolfgang MOTZ, Rainer RETTIG

Clin Sci (Lond) (2002) 103 (1): 101–106.

https://doi.org/10.1042/cs1030101

Published: 20 June 2002

...Sabine HERTWIG; Henry VÖLZKE; Daniel M. ROBINSON; Wolfgang MOTZ; Rainer RETTIG The present study was designed to prospectively test the hypothesis that gene polymorphisms of the renin-angiotensin system are associated with recurrent restenosis after repeated percutaneous transluminal coronary...

View articletitled, Angiotensinogen M235T gene polymorphism and recurrent restenosis after repeated percutaneous transluminal coronary angiography

Articles

Effects of angiotensin II (AT1) receptor blockade on cardiac vagal control in heart failure

J. C. VAILE, S. CHOWDHARY, F. OSMAN, H. F. ROSS, J. FLETCHER, W. A. LITTLER, J. H. COOTE, J. N. TOWNEND

Clin Sci (Lond) (2001) 101 (6): 559–566.

https://doi.org/10.1042/cs1010559

Published: 24 October 2001

...J. C. VAILE; S. CHOWDHARY; F. OSMAN; H. F. ROSS; J. FLETCHER; W. A. LITTLER; J. H. COOTE; J. N. TOWNEND The objective of the present study was to determine the autonomic effects of angiotensin II (AT 1 ) receptor blocker therapy in heart failure. In a randomized double-blind cross-over study, we...

View articletitled, Effects of angiotensin II (AT1) receptor blockade on cardiac vagal control in heart failure

Articles

Angiotensin receptors: distribution, signalling and function

Diem T. DINH, Albert G. FRAUMAN, Colin I. JOHNSTON, Maurice E. FABIANI

Clin Sci (Lond) (2001) 100 (5): 481–492.

https://doi.org/10.1042/cs1000481

Published: 27 March 2001

...Diem T. DINH; Albert G. FRAUMAN; Colin I. JOHNSTON; Maurice E. FABIANI Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at least two receptor subtypes, designated AT 1...

View articletitled, Angiotensin receptors: distribution, signalling and function

Articles

Comparative in vivo effects of irbesartan and losartan on angiotensin II receptor binding in the rat kidney following oral administration

Maurice E. FABIANI, Diem T. DINH, Labrini NASSIS, David J. CASLEY, Colin I. JOHNSTON

Clin Sci (Lond) (2000) 99 (4): 331–341.

https://doi.org/10.1042/cs0990331

Published: 15 September 2000

...Maurice E. FABIANI; Diem T. DINH; Labrini NASSIS; David J. CASLEY; Colin I. JOHNSTON We examined the ability of the new non-peptide angiotensin II receptor antagonist irbesartan to inhibit AT 1 receptors in vivo in the rat kidney following oral administration, compared with the prototype drug...

View articletitled, Comparative in vivo effects of irbesartan and losartan on angiotensin II receptor binding in the rat kidney following oral administration

Articles

The angiotensinogen gene 235T variant is associated with an increased risk of restenosis after percutaneous transluminal coronary angioplasty

Henry VÖLZKE, Sabine HERTWIG, Rainer RETTIG, Wolfgang MOTZ

Clin Sci (Lond) (2000) 99 (1): 19–25.

https://doi.org/10.1042/cs0990019

Published: 06 June 2000

..., genetic factors may be involved. In the present study, we investigated the associations between the angiotensinogen T174M and M235T, the angiotensin I-converting enzyme (ACE) I/D and the angiotensin II type 1 receptor A1166C gene polymorphisms and restenosis in 511 patients who had undergone successful...

View articletitled, The angiotensinogen gene 235T variant is associated with an increased risk of restenosis after percutaneous transluminal coronary angioplasty

Articles

Effect of Hypoxia and β 2 -Agonists on the Activity of the Renin-Angiotensin System in Normal Subjects

Evelyn A. Millar, Robert M. Angus, Jane E. Nally, Robin Clayton, Neil C. Thomson

Clin Sci (Lond) (1995) 89 (3): 273–276.

https://doi.org/10.1042/cs0890273

Published: 01 September 1995

...Evelyn A. Millar; Robert M. Angus; Jane E. Nally; Robin Clayton; Neil C. Thomson 1. We have reported that the renin-angiotensin system is activated in acute asthma, and also by high-dose nebulized β 2 -agonists. The contribution of other possible stimuli such as hypoxia is unknown. The present...

View articletitled, Effect of Hypoxia and β 2 -Agonists on the Activity of the Renin-Angiotensin System in Normal Subjects

Articles

Dissociation between Pressor Sensitivity in Vivo and Contractile Reactivity in Vitro to Angiotensin II in Rats with Experimental Cirrhosis

David J. Leehey

Clin Sci (Lond) (1993) 84 (5): 525–529.

https://doi.org/10.1042/cs0840525

Published: 01 May 1993

...David J. Leehey 1. Decreased pressor sensitivity to angiotensin II occurs in cirrhosis, but the mechanism remains unclear. 2. Angiotensin II dose-response studies were performed in conscious, chronically instrumented cirrhotic and control rats, and angiotensin II concentration-response studies were...

View articletitled, Dissociation between Pressor Sensitivity in Vivo and Contractile Reactivity in Vitro to Angiotensin II in Rats with Experimental Cirrhosis

Articles

Vascular Hypertrophy, Renin and Blood Pressure in the Young Spontaneously Hypertensive Rat

James J. Morton, Elisabeth C. Beattie, Sheila A. Griffin, Fiona MacPherson, Fiona Lyall, Domenico Russo

Clin Sci (Lond) (1990) 79 (5): 523–530.

https://doi.org/10.1042/cs0790523

Published: 01 November 1990

...James J. Morton; Elisabeth C. Beattie; Sheila A. Griffin; Fiona MacPherson; Fiona Lyall; Domenico Russo 1. Cardiovascular reactivity, blood vessel morphology, blood pressure and the activity of the renin—angiotensin system were determined in the 3-week-old spontaneously hypertensive (SHR), Wistar...

View articletitled, Vascular Hypertrophy, Renin and Blood Pressure in the Young Spontaneously Hypertensive Rat

Articles

Stimulation of Active Renin Release in Normal and Hypertensive Pregnancy

Mark A. Brown, Vivienne C. Zammit, Delma Adsett

Clin Sci (Lond) (1990) 79 (5): 505–511.

https://doi.org/10.1042/cs0790505

Published: 01 November 1990

... hypertension are able to stimulate release of active renin. 2. Active plasma renin concentration was measured as the generation of angiotensin I at physiological pH in the presence of excess renin substrate, and total renin concentration was determined in the same way after trypsin activation. Inactive plasma...

View articletitled, Stimulation of Active Renin Release in Normal and Hypertensive Pregnancy

Articles

Time-course and relationship of the early changes in renal sodium excretion and aldosterone secretion during dietary sodium restriction in normal man

D. J. S. Carmichael, M. S. Sutters, R. J. Unwin, D. Gordon, J. Few, V. H. T. James, J. Wadsworth, W. S. Peart

Clin Sci (Lond) (1990) 78 (6): 605–612.

https://doi.org/10.1042/cs0780605

Published: 01 June 1990

... angiotensin atrial natriuretic peptide diet diuresis kidney renin saliva sodium vasopressin Clinical Science (1990) 78,605-612 605 Time-course and relationship of the early changes in renal sodium excretion and aldosterone secretion during dietary sodium restriction in normal man D. J. S...

View articletitled, Time-course and relationship of the early changes in renal sodium excretion and aldosterone secretion during dietary sodium restriction in normal man

Articles

Renal water excretion before and after remission of nephrotic syndrome: Relationship between free water clearance and kidney function, arginine vasopressin, angiotensin II and aldosterone in plasma before and after oral water loading

E. B. Pedersen, H. Danielsen, S. S. Sørensen, B. Jespersen

Clin Sci (Lond) (1986) 71 (1): 97–104.

https://doi.org/10.1042/cs0710097

Published: 01 July 1986

... concentrations of arginine vasopressin (AVP), angiotensin II (ANG II) and aldosterone (Aldo), were determined before and three times during the first 4 h after loading. 2. D and C water increased to a significantly lower level ( P < 0.01) after water loading in patients with nephrotic syndrome than in control...

View articletitled, Renal water excretion before and after remission of nephrotic syndrome: Relationship between free water clearance and kidney function, arginine vasopressin, angiotensin II and aldosterone in plasma before and after oral water loading

Articles

Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?

J. W. O'Brien, N. A. Flavahan, T. L. Grant, J. C. McGrath, R. J. Marshall

Clin Sci (Lond) (1985) 68 (s10): 99s–104s.

https://doi.org/10.1042/cs068s099

Published: 01 January 1985

... smooth muscle, e.g. Ca 2+ -entry blockers or angiotensin converting enzyme (ACE) inhibitors. However, the extent of these influences depends on which agonist is used. 2. The pressor response to intravenous injection of α-adrenoceptor agonists consists of two phases: an initial rapid but transient...

View articletitled, Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?

Articles

Enzymatic Activity of Renin in Plasma of Normal and Uraemic Subjects

Theodore A. Kotchen, Tam T. Guyenne, Pierre Corvol, Joel Menard

Clin Sci (Lond) (1984) 67 (3): 365–368.

https://doi.org/10.1042/cs0670365

Published: 01 September 1984

...Theodore A. Kotchen; Tam T. Guyenne; Pierre Corvol; Joel Menard 1. Plasma renin reactivity (PRR) is the rate of angiotensin I production after addition of renin to plasma, minus endogenous renin activity. PRR is increased in plasma of patients with renal failure compared with that of normal...

View articletitled, Enzymatic Activity of Renin in Plasma of Normal and Uraemic Subjects

Articles

Responses of the Systemic Circulation and of the Renin—Angiotensin—Aldosterone System to Ketanserin at Rest and Exercise in Normal Man

Robert Fagard, Anne Cattaert, Paul Lijnen, Jan Staessen, Luc Vanhees, Emmanuel Moerman, Antoon Amery

Clin Sci (Lond) (1984) 66 (1): 17–25.

https://doi.org/10.1042/cs0660017

Published: 01 January 1984

... antagonist ketanserin on another occasion. The effects of ketanserin on the components of the renin—angiotensin—aldosterone system, on plasma catecholamines and on exercise capacity for graded uninterrupted exercise were also investigated. 2. At rest in recumbency rapid intravenous injection of 10 mg...

View articletitled, Responses of the Systemic Circulation and of the Renin—Angiotensin—Aldosterone System to Ketanserin at Rest and Exercise in Normal Man

Articles

Effect of Captopril on the Blood Pressure and Renal Responses to Acute Saline Loading in Normal and Essential Hypertensive Subjects

A. Mimran, J. Ribstein

Clin Sci (Lond) (1982) 63 (s8): 223s–225s.

https://doi.org/10.1042/cs063223s

Published: 01 October 1982

... with essential hypertension, whereas the renal response was unchanged in normotensive subjects. © 1982 The Biochemical Society and the Medical Research Society 1982 angiotensin converting enzyme essential hypertension volume expansion Clinical Science (1982) 63 ,223~225s 223s Effect of captopril...

View articletitled, Effect of Captopril on the Blood Pressure and Renal Responses to Acute Saline Loading in Normal and Essential Hypertensive Subjects

Articles

Effects of Meclofenamate and Captopril on Renal and other Regional Vascular Beds after Mild Haemorrhage in Conscious Rabbits

R. A. Banks, L. J. Beilin, J. Soltys, L. Davidson

Clin Sci (Lond) (1982) 62 (2): 169–176.

https://doi.org/10.1042/cs0620169

Published: 01 February 1982

...R. A. Banks; L. J. Beilin; J. Soltys; L. Davidson 1. The role of prostaglandins and angiotensin II in blood flow regulation was studied in conscious rabbits subjected to mild haemorrhage. 2. Haemorrhage caused a 13% fall in arterial pressure and a 21% fall in cardiac output, responses which were...

View articletitled, Effects of Meclofenamate and Captopril on Renal and other Regional Vascular Beds after Mild Haemorrhage in Conscious Rabbits

Articles

Effect of Converting Enzyme Inhibition on the Systemic and Renal Responses to Acute Isotonic Volume Expansion in Normal Man

A. Mimran, J. Ribstein

Clin Sci (Lond) (1981) 61 (s7): 285s–287s.

https://doi.org/10.1042/cs061285s

Published: 01 December 1981

... circulating angiotensin II may be one of the determinants of the natriuretic response to volume expansion in normal man. ChicalScience (1981) 6 1 , 2 8 5 ~ 2 8 7 s 285s Effect of converting enzyme inhibition on the systemic and renal responses to acute isotonic volume expansion in normal man A. M I M R A N...

View articletitled, Effect of Converting Enzyme Inhibition on the Systemic and Renal Responses to Acute Isotonic Volume Expansion in Normal Man

Articles

Specific Nuclear Binding of Angiotensin II by Rat Liver and Spleen Nuclei

R. N. Re, A. A. MacPhee, J. T. Fallon

Clin Sci (Lond) (1981) 61 (s7): 245s–247s.

https://doi.org/10.1042/cs061245s

Published: 01 December 1981

... specifically bound 125 I-labelled angiotensin II (ANG II) with high affinity ( K d ≅ 1.0 nmol/l). Saralasin ANG III and ANG II competed with tracer for ligand whereas ANG I did so less effectively and neurotensin not at all. 3. These results suggest the presence of specific nuclear intracellular ANG II...

View articletitled, Specific Nuclear Binding of Angiotensin II by Rat Liver and Spleen Nuclei

Articles

Distribution and Properties of Angiotensin-Converting Enzyme in Cerebral Microvessels of the Rabbit and Rat

P. Brecher, Vandana Hingorani, Karen Reininga, A. V. Chobanian

Clin Sci (Lond) (1981) 61 (s7): 249s–251s.

https://doi.org/10.1042/cs061249s

Published: 01 December 1981

...P. Brecher; Vandana Hingorani; Karen Reininga; A. V. Chobanian 1. Angiotensin-converting enzyme (ACE) activity was threefold greater in isolated cerebral microvessels obtained from rabbit brain than rat brain. 2. ACE activity was distributed throughout the cerebral microvasculature, since...

View articletitled, Distribution and Properties of Angiotensin-Converting Enzyme in Cerebral Microvessels of the Rabbit and Rat

Articles

Relationship between Plasma Renin and Cortisol in Hypertensive Patients

S. A. Atlas, D. B. Case, Jean E. Sealey, J. H. Laragh

Clin Sci (Lond) (1981) 61 (s7): 265s–268s.

https://doi.org/10.1042/cs061265s

Published: 01 December 1981

... that the renin—angiotensin system may interact with the pituitary—adrenal axis to influence circulating levels of cortisol. This effect might conceivably contribute to the pathogenesis of certain high-renin states. © 1981 The Biochemical Society and the Medical Research Society 1981 adrenocorticotrophin...

View articletitled, Relationship between Plasma Renin and Cortisol in Hypertensive Patients

Articles

Blunted Pressor Response to Angiotensin and Sympathomimetic Amines in Bile-Duct Ligated Dogs

J. P. M. Finberg, H. A. Syrop, O. S. Better

Clin Sci (Lond) (1981) 61 (5): 535–539.

https://doi.org/10.1042/cs0610535

Published: 01 November 1981

...J. P. M. Finberg; H. A. Syrop; O. S. Better 1. The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine and β-phenylethylamine were examined before and after bile-duct ligation in conscious trained dogs. 2. The pressor response to angiotensin II was markedly...

View articletitled, Blunted Pressor Response to Angiotensin and Sympathomimetic Amines in Bile-Duct Ligated Dogs

Articles

Comparison of Intrarenal and Extrarenal Converting-Enzyme Inhibition by SQ 20 881 on Canine Renal Blood Flow

P. C. Wong, B. G. Zimmerman

Clin Sci (Lond) (1981) 61 (5): 553–557.

https://doi.org/10.1042/cs0610553

Published: 01 November 1981

...P. C. Wong; B. G. Zimmerman 1. Successive infusions of SQ 20 881 given intra-arterially (i.a.) to the kidney at 0.4 and 0.8 μg min −1 kg −1 for 50 min each did not alter renal blood flow and renal vascular resistance in spite of 40–47% blockade of the angiotensin I (ANG I i.a.)-induced...

View articletitled, Comparison of Intrarenal and Extrarenal Converting-Enzyme Inhibition by SQ 20 881 on Canine Renal Blood Flow

Articles

Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms

M. G. Collis, J. R. Keddie

Clin Sci (Lond) (1981) 61 (3): 281–286.

https://doi.org/10.1042/cs0610281

Published: 01 September 1981

...M. G. Collis; J. R. Keddie 1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries...

View articletitled, Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms

Articles

Acute Effects of Captopril on Blood Pressure and Circulating Hormone Levels in Salt-Replete and Depleted Normal Subjects and Essential Hypertensive Patients

J. A. Millar, B. P. McGrath, P. G. Matthews, C. I. Johnston

Clin Sci (Lond) (1981) 61 (1): 75–83.

https://doi.org/10.1042/cs0610075

Published: 01 July 1981

...J. A. Millar; B. P. McGrath; P. G. Matthews; C. I. Johnston 1. The acute effects of a single oral dose of captopril on blood pressure, pulse rate and circulating levels of angiotensin I (ANG I), angiotensin II (ANG II), renin, bradykinin and catecholamines were studied in three groups: eight normal...

View articletitled, Acute Effects of Captopril on Blood Pressure and Circulating Hormone Levels in Salt-Replete and Depleted Normal Subjects and Essential Hypertensive Patients

Articles

Evidence That the Acute Hypotensive Effect of Captopril in Dogs is Not Wholly Explained by a Reduction of Plasma Angiotensin II and its Direct Vasoconstrictor Effect

M. Tree, J. J. Morton

Clin Sci (Lond) (1980) 59 (6): 451–456.

https://doi.org/10.1042/cs0590451

Published: 01 December 1980

...M. Tree; J. J. Morton 1. Captopril infused into sodium-loaded dogs produced a fall in both blood pressure [117 ± 9.7 to 96.6 ± 11.4 (sd) mmHg] and plasma angiotensin II [11.0 ± 3.0 to 1.6 ± 1.3 (sd) pmol/l]. Plasma aldosterone fell while both blood angiotensin I and renin concentration rose. 2...

View articletitled, Evidence That the Acute Hypotensive Effect of Captopril in Dogs is Not Wholly Explained by a Reduction of Plasma Angiotensin II and its Direct Vasoconstrictor Effect

Articles

The Renin-Angiotensin-Aldosterone System in the Maintenance of Blood Pressure, Aldosterone Secretion and Sodium Balance in Normotensive Subjects

G. A. MacGregor, N. D. Markandu, J. E. Roulston, J. C. Jones, J. J. Morton

Clin Sci (Lond) (1980) 59 (s6): 95s–99s.

https://doi.org/10.1042/cs059095s

Published: 01 December 1980

... but not the high sodium diet. 4. These results suggest that the renin-angiotensin-aldosterone system is a normal mechanism for maintaining blood pressure and aldosterone secretion in normotensive man. The system may also be involved in the maintenance of sodium balance. 5. These results may lead to a better...

View articletitled, The Renin-Angiotensin-Aldosterone System in the Maintenance of Blood Pressure, Aldosterone Secretion and Sodium Balance in Normotensive Subjects

Articles

Immunocytochemical Localization of Angiotensin II and Vasopressin in Rat Hypothalamus: Evidence for Production in the Same Neuron

M. M. Kilcoyne, D. L. Hoffman, E. A. Zimmerman

Clin Sci (Lond) (1980) 59 (s6): 57s–60s.

https://doi.org/10.1042/cs059057s

Published: 01 December 1980

...M. M. Kilcoyne; D. L. Hoffman; E. A. Zimmerman 1. By immunoperoxidase technique, immunoreactive angiotensin II (ANG II) was located in the cell bodies of many magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus and their pathways to median eminence and posterior...

View articletitled, Immunocytochemical Localization of Angiotensin II and Vasopressin in Rat Hypothalamus: Evidence for Production in the Same Neuron

Articles

Converting Enzyme Inhibition during Chronic Angiotensin II Infusion in Rats: Evidence against a Non-Angiotensin Mechanism

S. C. Textor, H. R. Brunner, H. Gavras

Clin Sci (Lond) (1980) 59 (s6): 71s–74s.

https://doi.org/10.1042/cs059071s

Published: 01 December 1980

...S. C. Textor; H. R. Brunner; H. Gavras 1. To investigate the non-angiotensin effects of converting enzyme inhibition, angiotensin II was infused intravenously at 30 ng/min for 9 days in conscious rats to produce moderate blood pressure elevation. One group was given captopril (SQ 14 225) by gavage...

View articletitled, Converting Enzyme Inhibition during Chronic Angiotensin II Infusion in Rats: Evidence against a Non-Angiotensin Mechanism

Update search

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only