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Keywords: Angiotensin II
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Clin Sci (Lond) (2025) 139 (03): CS20241155.
Published: 04 February 2025
... control could restore the balance between classic [angiotensin I-converting enzyme 2 (ACE)/angiotensin II (Ang II)] and counterregulatory [angiotensin I-converting enzyme 2 (ACE2)/Ang (1-7)] RAS, thereby mitigating lung inflammation. Male spontaneously hypertensive rats (SHRs) were treated with either...
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Clin Sci (Lond) (2024) 138 (11): 645–662.
Published: 29 May 2024
...Donald E. Kohan; Patricia W. Bedard; Celia Jenkinson; Bruce Hendry; Radko Komers Simultaneous inhibition of angiotensin II AT 1 and endothelin ET A receptors has emerged as a promising approach for treatment of chronic progressive kidney disease. This therapeutic approach has been advanced...
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Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress...
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Clin Sci (Lond) (2021) 135 (2): 259–274.
Published: 22 January 2021
... to mediate deoxycorticosterone acetate (DOCA)-salt hypertension, an animal model for human primary hyperaldosteronism. Here, we determined whether brainstem angiotensin II is generated from locally synthesized angiotensinogen and mediates DOCA-salt hypertension. To this end, chronic DOCA-salt-hypertensive...
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Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... evolution shows greater lethality in patients with antecedent cardiovascular disease, diabetes, or even obesity questioned the potential unfavorable contribution of angiotensin converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor blockers as facilitators of adverse outcomes due...
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Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
.... ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract...
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Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Autophagy Hepatic fibrosis NADPH oxidase...
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Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
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Clin Sci (Lond) (2018) 132 (8): 901–904.
Published: 30 April 2018
... dysbiosis is linked to hypertension . Hypertension 65 , 1331 – 1340 10.1161/HYPERTENSIONAHA.115.05315 25870193 4 Karbach S.H. , Schonfelder T. , Brandao I. , Wilms E. , Hormann N. , Jackel S. ( 2016 ) Gut microbiota promote angiotensin II-induced arterial...
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Clin Sci (Lond) (2018) 132 (1): 127–130.
Published: 11 January 2018
... for their quantification. Correspondence: A.H. Jan Danser ( [email protected] ) 11 12 2017 20 12 2017 21 12 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 AA autoantibody AT 1 R angiotensin II type 1 receptor RAAS...
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Clin Sci (Lond) (2015) 128 (10): 665–678.
Published: 20 February 2015
..., but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. In the present study, we attempted to investigate the role of Ankrd1 on AngII (angiotensin II)- or pressure-overload-induced cardiomyocyte apoptosis. In the failing hearts of mice with pressure overload, the protein expression...
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Clin Sci (Lond) (2014) 127 (9): 549–557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (renin–angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic...
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Clin Sci (Lond) (2014) 127 (7): 463–474.
Published: 17 June 2014
... administered for 14 days [10 mg/kg per day intraperitoneally (i.p.)]. Both EET-A and EET-X lowered blood pressure in spontaneously hypertensive rats (SHRs) and in angiotensin II (AngII) hypertension. On day 14, the mean arterial pressures in EET analogue-treated AngII-hypertensive and SHRs were 30–50 mmHg (EET...
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Clin Sci (Lond) (2014) 127 (4): 251–264.
Published: 16 April 2014
...María Gabriela Morales; Johanna Ábrigo; Carla Meneses; Felipe Simon; Franco Cisternas; Juan Carlos Rivera; Yaneisi Vazquez; Claudio Cabello-Verrugio AngII (angiotensin II) induces pathological conditions such as fibrosis in skeletal muscle. In this process, AngII increases ROS (reactive oxygen...
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Clin Sci (Lond) (2014) 127 (2): 123–134.
Published: 28 March 2014
.... In the present study, we examined whether aliskiren limits the progression of AAA (abdominal aortic aneurysm), VH (ventricular hypertrophy) and atherosclerosis in an AngII (angiotensin II)-infused mouse model. ApoE −/− (apolipoprotein-E-deficient) mice were infused subcutaneously with AngII (1000 ng/kg of body...
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Clin Sci (Lond) (2014) 126 (12): 837–844.
Published: 26 February 2014
... for irisin levels in adults, explaining 17% of the variance, whereas in children AngII (angiotensin II) was the most significant predictor of irisin levels, explaining 19% of the variance ( P =0.003). Circulating irisin appears to be maternally inherited and is predicted by HDL-cholesterol in adults...
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Clin Sci (Lond) (2014) 126 (11): 753–774.
Published: 13 February 2014
... and kinins. angiotensin II angiotensin II type 1 receptor (AT 1 receptor) biased agonism bradykinin G-protein-coupled receptor (GPCR) signalling pathway The term ‘vasoactive peptides’, as it literally suggests, represents a group of biologically active peptides, to which angiotensins...
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Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
.... The RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(1–7)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
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Clin Sci (Lond) (2012) 123 (7): 399–416.
Published: 07 June 2012
... 2 2012 30 3 2012 23 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II arterial calcification arterial stiffness Klotho pulse wave velocity remodelling phosphorus CKD (chronic kidney disease) is a highly prevalent condition...
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Clin Sci (Lond) (2012) 123 (5): 273–284.
Published: 16 May 2012
... by the mineralocorticoid receptor antagonist eplerenone [ 25 ]. The latter reduced the expression of plasma-membrane and intracellular AT 1 receptors, which might have contributed to the observed effects. angiotensin II angiotensin type 1 receptor cardiovascular system diabetes intracellular renin...
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Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
... (angiotensin-converting enzyme) and the AT 1 receptor [AngII (angiotensin II) type 1 receptor], which play an active role in promoting inflammation and deposition of extracellular matrix. In addition, the more recently recognized structural homologue of ACE, ACE2, is also up-regulated. ACE2 catalyses...
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Clin Sci (Lond) (2012) 122 (11): 513–527.
Published: 10 February 2012
... in this transgenic model of angiotensin II-dependent hypertension. All animals used in the present study were bred at the Center for Experimental Medicine from stock animals supplied from Max Delbrück Center for Molecular Medicine, Berlin, Germany (a gift from Dr Michael Bader and Dr Detlev Ganten). The TGR...
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Clin Sci (Lond) (2012) 122 (2): 63–73.
Published: 20 September 2011
... expansion markedly decreased the plasma levels of renin, AngII (angiotensin II) and aldosterone (all P <0.001), while MABP (oscillometry), heart rate, cardiac output (impedance cardiography), RPF (by p -aminohippurate), GFR [glomerular filtration rate; by using 51 Cr-labelled EDTA] and plasma [Na...
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Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
...Sanja Bosnyak; Emma S. Jones; Arthur Christopoulos; Marie-Isabel Aguilar; Walter G. Thomas; Robert E. Widdop AT 1 R (angiotensin type 1 receptor) and AT 2 R (angiotensin type 2 receptor) are well known to be involved in the complex cardiovascular actions of AngII (angiotensin II). However, shorter...
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Clin Sci (Lond) (2010) 118 (7): 459–461.
Published: 12 January 2010
... of Clinical Science , Giachini and co-workers found that clopidogrel could normalize the increased phenylephrine-induced vascular contraction and the impaired acetylcholine-induced vasodilation in mesenteric arteries from AngII (angiotensin II)-infused Sprague–Dawley rats. This might develop a new area...
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Clin Sci (Lond) (2010) 118 (4): 291–301.
Published: 16 November 2009
... Sprague–Dawley rats were fed either a normal (7% fat) or high-fat (36% fat) diet for 6 weeks and osmotic pumps were implanted to deliver ANG (angiotensin II) or vehicle for an additional 4 weeks. Treatment with the high-fat diet did not alter ANG-induced hypertension compared with the normal diet (174±6...
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Clin Sci (Lond) (2008) 114 (5): 375–380.
Published: 01 February 2008
..., catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls ( P =0.036). In addition, angiotensin II and ACE activity were higher in SGA boys ( P =0.024 and P =0.050 respectively). There was a significant association...
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Clin Sci (Lond) (2007) 113 (3): 109–118.
Published: 02 July 2007
... are up-regulated in fibrotic livers of humans and in experimental animal models. Angiotensin II, the main physiological effector molecule of this system, mediates liver fibrosis by stimulating fibroblast proliferation (myofibroblast and hepatic stellate cells), infiltration of inflammatory cells...
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