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Keywords: Angiotensin II
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Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
..., Guangzhou 510515, China. This Correction follows an Expression of Concern relating to this article previously published by Portland Press. Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress © 2021 The Author(s). 2021 This is an open access article published...
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Clin Sci (Lond) (2021) 135 (2): 259–274.
Published: 22 January 2021
... to mediate deoxycorticosterone acetate (DOCA)-salt hypertension, an animal model for human primary hyperaldosteronism. Here, we determined whether brainstem angiotensin II is generated from locally synthesized angiotensinogen and mediates DOCA-salt hypertension. To this end, chronic DOCA-salt-hypertensive...
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Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... evolution shows greater lethality in patients with antecedent cardiovascular disease, diabetes, or even obesity questioned the potential unfavorable contribution of angiotensin converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor blockers as facilitators of adverse outcomes due...
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Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
.... ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract...
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Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Autophagy Hepatic fibrosis NADPH oxidase...
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Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
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Clin Sci (Lond) (2018) 132 (8): 901–904.
Published: 30 April 2018
..., and hypertension. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 23 03 2018 11 04 2018 13 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 angiotensin II hypertension microbiota patients...
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Clin Sci (Lond) (2018) 132 (1): 127–130.
Published: 11 January 2018
...-regulate sFlt-1, which inactivates VEGF, they may also decrease aldosterone, because VEGF normally enhances adrenal capillary density. Finally, endothelin-1 (ET-1) suppresses renin release and would thus decrease both renin and aldosterone in parallel. angiotensin II autoantibody hypertension...
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Clin Sci (Lond) (2015) 128 (10): 665–678.
Published: 20 February 2015
..., but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. In the present study, we attempted to investigate the role of Ankrd1 on AngII (angiotensin II)- or pressure-overload-induced cardiomyocyte apoptosis. In the failing hearts of mice with pressure overload, the protein expression...
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Clin Sci (Lond) (2015) 128 (9): 559–565.
Published: 11 February 2015
... Satoru Eguchi (email seguchi@temple.edu ) 28 10 2014 17 12 2014 22 12 2014 22 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 Angiotensin II (Ang II) has been implicated in the development of abdominal aortic aneurysm (AAA). In vascular smooth...
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Clin Sci (Lond) (2014) 127 (9): 549–557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (renin–angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic...
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Clin Sci (Lond) (2014) 127 (7): 463–474.
Published: 17 June 2014
... administered for 14 days [10 mg/kg per day intraperitoneally (i.p.)]. Both EET-A and EET-X lowered blood pressure in spontaneously hypertensive rats (SHRs) and in angiotensin II (AngII) hypertension. On day 14, the mean arterial pressures in EET analogue-treated AngII-hypertensive and SHRs were 30–50 mmHg (EET...
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Clin Sci (Lond) (2014) 127 (4): 251–264.
Published: 16 April 2014
...María Gabriela Morales; Johanna Ábrigo; Carla Meneses; Felipe Simon; Franco Cisternas; Juan Carlos Rivera; Yaneisi Vazquez; Claudio Cabello-Verrugio AngII (angiotensin II) induces pathological conditions such as fibrosis in skeletal muscle. In this process, AngII increases ROS (reactive oxygen...
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Clin Sci (Lond) (2014) 127 (2): 123–134.
Published: 28 March 2014
.... In the present study, we examined whether aliskiren limits the progression of AAA (abdominal aortic aneurysm), VH (ventricular hypertrophy) and atherosclerosis in an AngII (angiotensin II)-infused mouse model. ApoE −/− (apolipoprotein-E-deficient) mice were infused subcutaneously with AngII (1000 ng/kg of body...
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Clin Sci (Lond) (2014) 126 (12): 837–844.
Published: 26 February 2014
... for irisin levels in adults, explaining 17% of the variance, whereas in children AngII (angiotensin II) was the most significant predictor of irisin levels, explaining 19% of the variance ( P =0.003). Circulating irisin appears to be maternally inherited and is predicted by HDL-cholesterol in adults...
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Clin Sci (Lond) (2014) 126 (11): 753–774.
Published: 13 February 2014
... angiotensinogen upon action of renin, is converted into AngII (angiotensin II) by ACE (angiotensin-converting enzyme), which is abundantly found in the endothelium [ 37 ]. AngII binds with high affinity to two GPCRs (G-protein-coupled receptors) named the AT 1 (AngII type 1) and AT 2 (AngII type 2) receptors...
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Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
.... The RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(1–7)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
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Clin Sci (Lond) (2012) 123 (7): 399–416.
Published: 07 June 2012
... inhibitors, such as fetuin A, was decreased [ 26 ]. At the level of inflammatory markers, calcified lesions from CKD patients had enhanced macrophage infiltration and CRP (C-reactive protein) expression, as well as intense C5b deposition [ 26 ]. angiotensin II arterial calcification arterial stiffness...
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Clin Sci (Lond) (2012) 123 (5): 273–284.
Published: 16 May 2012
... intracellular Ca 2+ stores [ 40 ]. These effects were blocked by the intracellular, but not extracellular, application of losartan, an observation similar to that described for VSMCs. angiotensin II angiotensin type 1 receptor cardiovascular system diabetes intracellular renin–angiotensin system...
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Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
... (angiotensin-converting enzyme) and the AT 1 receptor [AngII (angiotensin II) type 1 receptor], which play an active role in promoting inflammation and deposition of extracellular matrix. In addition, the more recently recognized structural homologue of ACE, ACE2, is also up-regulated. ACE2 catalyses...
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Clin Sci (Lond) (2012) 122 (11): 513–527.
Published: 10 February 2012
... in this transgenic model of angiotensin II-dependent hypertension. Correspondence: Dr Jan Neckář (email neckar@biomed.cas.cz ). 1 12 2011 16 12 2011 16 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 In this series, TGR and HanSD rats were subjected...
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Clin Sci (Lond) (2012) 122 (2): 63–73.
Published: 20 September 2011
... expansion markedly decreased the plasma levels of renin, AngII (angiotensin II) and aldosterone (all P <0.001), while MABP (oscillometry), heart rate, cardiac output (impedance cardiography), RPF (by p -aminohippurate), GFR [glomerular filtration rate; by using 51 Cr-labelled EDTA] and plasma [Na...
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Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
...Sanja Bosnyak; Emma S. Jones; Arthur Christopoulos; Marie-Isabel Aguilar; Walter G. Thomas; Robert E. Widdop AT 1 R (angiotensin type 1 receptor) and AT 2 R (angiotensin type 2 receptor) are well known to be involved in the complex cardiovascular actions of AngII (angiotensin II). However, shorter...
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Clin Sci (Lond) (2010) 118 (7): 459–461.
Published: 12 January 2010
... of Clinical Science , Giachini and co-workers found that clopidogrel could normalize the increased phenylephrine-induced vascular contraction and the impaired acetylcholine-induced vasodilation in mesenteric arteries from AngII (angiotensin II)-infused Sprague–Dawley rats. This might develop a new area...
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Clin Sci (Lond) (2010) 118 (4): 291–301.
Published: 16 November 2009
... Sprague–Dawley rats were fed either a normal (7% fat) or high-fat (36% fat) diet for 6 weeks and osmotic pumps were implanted to deliver ANG (angiotensin II) or vehicle for an additional 4 weeks. Treatment with the high-fat diet did not alter ANG-induced hypertension compared with the normal diet (174±6...
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Clin Sci (Lond) (2008) 114 (5): 375–380.
Published: 01 February 2008
..., catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls ( P =0.036). In addition, angiotensin II and ACE activity were higher in SGA boys ( P =0.024 and P =0.050 respectively). There was a significant association...
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Clin Sci (Lond) (2007) 113 (3): 109–118.
Published: 02 July 2007
... are up-regulated in fibrotic livers of humans and in experimental animal models. Angiotensin II, the main physiological effector molecule of this system, mediates liver fibrosis by stimulating fibroblast proliferation (myofibroblast and hepatic stellate cells), infiltration of inflammatory cells...
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Clin Sci (Lond) (2005) 108 (2): 113–119.
Published: 21 January 2005
...Marina CHRISTENSEN; Hans IBSEN; René WORCK ANG II (angiotensin II) facilitates catecholamine release from the adrenal medulla and neuronal NE (noradrenaline) release. Since animal experiments point to specific sympatho-inhibitory properties of the AT 1 (ANG II type 1)-receptor blocker EPRO...
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