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Keywords: Angiotensin-(1-7)
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Articles

Countering the classical renin–angiotensin system

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Natalia M. Noto, Yazmin M. Restrepo, Robert C. Speth
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2619–2623.
https://doi.org/10.1042/CS20211043
Published: 08 December 2021
.... In this commentary, we discuss potential concerns with this model while also highlighting advances that can ensue from this significant technical feat. ACE angiotensin-converting enzyme ACE2 angiotensin-converting enzyme 2 Ang II angiotensin II Ang-(1-7) angiotensin-(1-7) ANP atrial...
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Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein

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Daniele T. Alves, Luiz Felipe Mendes, Walkyria O. Sampaio, Leda M.C. Coimbra-Campos, Maria Aparecida R. Vieira, Anderson J. Ferreira, Almir S. Martins, Elena Popova, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Robson A.S. Santos, Maria Jose Campagnole-Santos
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (18): 2197–2216.
https://doi.org/10.1042/CS20210599
Published: 21 September 2021
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Angiotensin-(1-7) ANP Arterial Pressure Brain endothelial cells Transgenic rats To measure urine volume and water intake, animals were individually housed in metabolic cages (Nalgene, U.S.A...
View articletitled, Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein
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Includes: Supplementary data
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ACE2 in the renin–angiotensin system

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
https://doi.org/10.1042/CS20200478
Published: 02 December 2020
... angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions to allow a rapid and coordinated...
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Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Fernando M. Reis, Adelina M. Reis
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2929–2941.
https://doi.org/10.1042/CS20200865
Published: 16 November 2020
... direction, and some of the actions ascribed to Ang II are actually mediated by Ang-(1-7) formation. The redundancy of both RAS axes seems to be important to guarantee the success of the female reproductive process. ACE2 Angiotensin-(1-7) erectile dysfunction Mas receptor ovulation reproduction...
View articletitled, Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions
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Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Carlos M. Ferrario, Sarfaraz Ahmad, Leanne Groban
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
https://doi.org/10.1042/CS20200901
Published: 16 October 2020
... , e21 10.1016/S2213-2600(20)30116-8 32. Ferrario C.M. , Trask A.J. and Jessup J.A. ( 2005 ) Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function . Am. J. Physiol. Heart Circ. Physiol...
View articletitled, Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease
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ACE2 as therapeutic agent

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Qiuhong Li, Maria B. Grant, Elaine M. Richards, Mohan K. Raizada
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2581–2595.
https://doi.org/10.1042/CS20200570
Published: 14 October 2020
.... ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract...
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Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data

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Andrew M. South, Hossam A. Shaltout, Lisa K. Washburn, Alexa S. Hendricks, Debra I. Diz, Mark C. Chappell
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (1): 55–74.
https://doi.org/10.1042/CS20171550
Published: 08 January 2019
... ( [email protected] ) 03 08 2018 20 11 2018 03 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 angiotensin converting enzyme 2 angiotensin-(1-7) ACE fetal programming Cardiovascular disease including its...
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Includes: Supplementary data
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The depressor axis of the renin–angiotensin system and brain disorders: a translational approach

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Mariela M. Gironacci, Augusto Vicario, Gustavo Cerezo, Mauro G. Silva
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
https://doi.org/10.1042/CS20180189
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke Regarding ACE2, ACE2 is widespread...
View articletitled, The depressor axis of the renin–angiotensin system and brain disorders: a translational approach
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Articles

Mas receptor contributes to pregnancy-induced cardiac remodelling

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Cintia do Carmo e Silva, Jônathas Fernandes Queiroz de Almeida, Larissa Matuda Macedo, Marcos Barrouin Melo, Gustavo Rodrigues Pedrino, Fernanda Cristina Alcantara dos Santos, Manoel Francisco Biancardi, Robson Augusto Souza dos Santos, Adryano Augustto Valladão de Carvalho, Elizabeth Pereira Mendes, Diego Basile Colugnati, Renata Mazaro-Costa, Carlos Henrique de Castro
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (24): 2305–2316.
https://doi.org/10.1042/CS20160095
Published: 10 November 2016
... In the present study, we have showed that the Ang-(1–7)/receptor Mas axis contributes to cardiac remodelling development induced by pregnancy. A-779 Angiotensin-(1–7) cardiac hypertrophy fibrosis heart function • In the present study, we have evaluated the participation of the Mas receptor...
View articletitled, Mas receptor contributes to pregnancy-induced cardiac remodelling
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Angiotensin-(1–7) decreases the expression of collagen I via TGF-β1/Smad2/3 and subsequently inhibits fibroblast–myofibroblast transition

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Jian Ping Zhou, Wei Tang, Yun Feng, Ning Li, Chen Juan Gu, Qing Yun Li, Huan Ying Wan
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1983–1991.
https://doi.org/10.1042/CS20160193
Published: 30 September 2016
...Jian Ping Zhou; Wei Tang; Yun Feng; Ning Li; Chen Juan Gu; Qing Yun Li; Huan Ying Wan Previous studies have shown that the RAS (renin–angiotensin system) might participate in airway remodelling in asthma. As a main component of the RAS, Ang-(1–7) [angiotensin-(1–7)] has been reported in few studies...
View articletitled, Angiotensin-(1–7) decreases the expression of collagen I via TGF-β1/Smad2/3 and subsequently inhibits fibroblast–myofibroblast transition
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Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats

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Ana Flávia Almeida-Santos, Lucas M. Kangussu, Fabrício A. Moreira, Robson A.S. Santos, Daniele C. Aguiar, Maria José Campagnole-Santos
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1247–1255.
https://doi.org/10.1042/CS20160116
Published: 13 June 2016
...Ana Flávia Almeida-Santos; Lucas M. Kangussu; Fabrício A. Moreira; Robson A.S. Santos; Daniele C. Aguiar; Maria José Campagnole-Santos Angiotensin-(1–7) [Ang-(1–7)], a counter-regulatory peptide of the renin–angiotensin system (RAS) exerts its effects through the G-protein-coupled receptor Mas...
View articletitled, Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats
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Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1–7) through a p38 MAPK-dependent mechanism

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María Gabriela Morales, Hugo Olguín, Gabriella Di Capua, Enrique Brandan, Felipe Simon, Claudio Cabello-Verrugio
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (6): 461–476.
https://doi.org/10.1042/CS20140840
Published: 22 June 2015
... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(1–7)], through its Mas receptor, has...
View articletitled, Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1–7) through a p38 MAPK-dependent mechanism
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Includes: Supplementary data
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Angiotensin-(1–7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice

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Yixuan Shi, Chao-Sheng Lo, Ranjit Padda, Shaaban Abdo, Isabelle Chenier, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (10): 649–663.
https://doi.org/10.1042/CS20140329
Published: 20 February 2015
...Yixuan Shi; Chao-Sheng Lo; Ranjit Padda; Shaaban Abdo; Isabelle Chenier; Janos G. Filep; Julie R. Ingelfinger; Shao-Ling Zhang; John S.D. Chan We investigated the relationship between Ang-(1–7) [angiotensin-(1–7)] action, sHTN (systolic hypertension), oxidative stress, kidney injury, ACE2...
View articletitled, Angiotensin-(1–7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice
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Includes: Supplementary data
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Angiotensin-(1–7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism

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Franco Cisternas, María Gabriela Morales, Carla Meneses, Felipe Simon, Enrique Brandan, Johanna Abrigo, Yaneisi Vazquez, Claudio Cabello-Verrugio
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (5): 307–319.
https://doi.org/10.1042/CS20140215
Published: 05 November 2014
...) degradation and increase in the expression of two muscle-specific ubiquitin ligases: atrogin-1 and MuRF-1. Angiotensin II (AngII) induces muscle atrophy. Angiotensin-(1–7) [Ang-(1–7)], through its receptor Mas, produces the opposite effects than AngII. We assessed the effects of Ang-(1–7) on the skeletal...
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Includes: Supplementary data
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Protective axis of the renin–angiotensin system in the brain

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Mariela M. Gironacci, Flavia M. Cerniello, Nadia A. Longo Carbajosa, Jorge Goldstein, Bruno D. Cerrato
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (5): 295–306.
https://doi.org/10.1042/CS20130450
Published: 07 May 2014
...), and the depressor arm represented by Ang-(1–7) [angiotensin-(1–7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...
View articletitled, Protective axis of the renin–angiotensin system in the brain
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The Ang-(1–7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle

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María Gabriela Morales, Johanna Ábrigo, Carla Meneses, Felipe Simon, Franco Cisternas, Juan Carlos Rivera, Yaneisi Vazquez, Claudio Cabello-Verrugio
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (4): 251–264.
https://doi.org/10.1042/CS20130585
Published: 16 April 2014
.... In the present study, we investigated whether Ang-(1–7) [angiotensin-(1–7)], through the Mas-1 receptor, can counteract the signalling induced by AngII in mouse skeletal muscle and cause a decrease in the expression and further activity of TGF-β1 in skeletal muscle cells. Our results show that Ang-(1–7...
View articletitled, The Ang-(1–7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle
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The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure

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Irving H. Zucker, Liang Xiao, Karla K. V. Haack
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (10): 695–706.
https://doi.org/10.1042/CS20130294
Published: 27 January 2014
.... The RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(1–7)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
View articletitled, The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure
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Modulation of the action of insulin by angiotensin-(1–7)

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Fernando P. Dominici, Valeria Burghi, Marina C. Muñoz, Jorge F. Giani
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (9): 613–630.
https://doi.org/10.1042/CS20130333
Published: 14 January 2014
... drugs that block the RAS (renin–angiotensin system) may also act to prevent diabetes. Despite its long history, new components within the RAS continue to be discovered. Among them, Ang-(1–7) [angiotensin-(1–7)] has gained special attention as a counter-regulatory hormone opposing many of the AngII...
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Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress

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Nicola E. Clarke, Nikolai D. Belyaev, Daniel W. Lambert, Anthony J. Turner
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (7): 507–516.
https://doi.org/10.1042/CS20130291
Published: 11 December 2013
...) [angiotensin-(1–7)]. Enhanced ACE2 expression may be protective in diabetes, cardiovascular disease and cancer. However, relatively little is known about the specific physiological factors regulating ACE2 expression. In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR...
View articletitled, Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
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Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications

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Vaibhav B. Patel, Nirmal Parajuli, Gavin Y. Oudit
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (7): 471–482.
https://doi.org/10.1042/CS20130344
Published: 06 December 2013
... shown clinical benefits. ACE2, the recently discovered homologue of ACE, is a monocarboxypeptidase which converts AngII into Ang-(1–7) [angiotensin-(1–7)] which, by virtue of its actions on the MasR (Mas receptor), opposes the effects of AngII. In animal models of diabetes, an early increase in ACE2...
View articletitled, Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications
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An evolving story of angiotensin-II-forming pathways in rodents and humans

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Carlos Maria Ferrario, Sarfaraz Ahmad, Sayaka Nagata, Stephen W. Simington, Jasmina Varagic, Neal Kon, Louis Joseph Dell’Italia
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (7): 461–469.
https://doi.org/10.1042/CS20130400
Published: 06 December 2013
...Carlos Maria Ferrario; Sarfaraz Ahmad; Sayaka Nagata; Stephen W. Simington; Jasmina Varagic; Neal Kon; Louis Joseph Dell’Italia Lessons learned from the characterization of the biological roles of Ang-(1–7) [angiotensin-(1–7)] in opposing the vasoconstrictor, proliferative and prothrombotic actions...
View articletitled, An evolving story of angiotensin-II-forming pathways in rodents and humans
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Angiotensin II type 1 receptor blockade restores angiotensin-(1–7)-induced coronary vasodilation in hypertrophic rat hearts

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Álvaro P. S. Souza, Deny B. S. Sobrinho, Jônathas F. Q. Almeida, Gisele M. M. Alves, Larissa M. Macedo, Juliana E. Porto, Eneida F. Vêncio, Diego B. Colugnati, Robson A. S. Santos, Anderson J. Ferreira, Elizabeth P. Mendes, Carlos H. Castro
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (9): 449–459.
https://doi.org/10.1042/CS20120519
Published: 08 July 2013
... the coronary effects of Ang-(1–7) [angiotensin-(1–7)] in hypertrophic rat hearts. Heart hypertrophy was induced by abdominal aorta CoA (coarctation). Ang-(1–7) and AVE 0991, a non-peptide Mas-receptor agonist, at picomolar concentration, induced a significant vasodilation in hearts from sham-operated rats...
View articletitled, Angiotensin II type 1 receptor blockade restores angiotensin-(1–7)-induced coronary vasodilation in hypertrophic rat hearts
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Neuromodulatory role of angiotensin-(1–7) in the central nervous system

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Mariela M. Gironacci, Nadia A. Longo Carbajosa, Jorge Goldstein, Bruno D. Cerrato
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (2): 57–65.
https://doi.org/10.1042/CS20120652
Published: 26 March 2013
...Mariela M. Gironacci; Nadia A. Longo Carbajosa; Jorge Goldstein; Bruno D. Cerrato Ang-(1–7) [angiotensin-(1–7)] constitutes an important functional end-product of the RAS (renin–angiotensin system) endogenously formed from AngI (angiotensin I) or AngII (angiotensin II) through the catalytic...
View articletitled, Neuromodulatory role of angiotensin-(1–7) in the central nervous system
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Angiotensin-(1–7): beyond the cardio-renal actions

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Danielle G. Passos-Silva, Thiago Verano-Braga, Robson A. S. Santos
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (7): 443–456.
https://doi.org/10.1042/CS20120461
Published: 07 December 2012
... of the actions of the RAS. However, over the past 10 years, several studies have presented evidence for the existence of a new arm of the RAS, namely the ACE (angiotensin-converting enzyme) 2/Ang-(1–7) [angiotensin-(1–7)]/Mas axis. Ang-(1–7) can be produced from AngI or AngII via endo- or carboxy-peptidases...
View articletitled, Angiotensin-(1–7): beyond the cardio-renal actions
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Angiotensin-converting enzyme 2 regulates renal atrial natriuretic peptide through angiotensin-(1–7)

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Stella Bernardi, Wendy C. Burns, Barbara Toffoli, Raelene Pickering, Maryio Sakoda, Despina Tsorotes, Edward Grixti, Elena Velkoska, Louise M. Burrell, Colin Johnston, Merlin C. Thomas, Bruno Fabris, Christos Tikellis
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (1): 29–37.
https://doi.org/10.1042/CS20110403
Published: 12 March 2012
... by real-time quantitative RT–PCR using the TaqMan system based on real-time detection of accumulated fluorescence. Renal ANP gene expression was measured following the same method in RNA extracted from the kidneys of the Ang-(1–7)-infused rats and their controls. angiotensin-(1–7) angiotensin...
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Relative affinity of angiotensin peptides and novel ligands at AT 1 and AT 2 receptors

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Sanja Bosnyak, Emma S. Jones, Arthur Christopoulos, Marie-Isabel Aguilar, Walter G. Thomas, Robert E. Widdop
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (7): 297–303.
https://doi.org/10.1042/CS20110036
Published: 07 June 2011
...-(1–7) [angiotensin-(1–7)]. Of note, although AngIV and Ang-(1–7) exhibited only modest affinity at AT 2 R compared with AngII, these two angiotensin peptides, together with AngIII, had substantial AT 2 R selectivity over AT 1 R. Collectively, our results suggest that shorter angiotensin peptides can...
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Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition

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Elena Velkoska, Rachael G. Dean, Luke Burchill, Vicki Levidiotis, Louise M. Burrell
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (4): 269–279.
https://doi.org/10.1042/CS20090318
Published: 16 November 2009
... equally to the work. angiotensin-(1–7) kidney mas receptor renal injury renin–angiotensin system (RAS) Alterations within the RAS (renin–angiotensin system) are pivotal for the development and progression of renal disease [ 1 , 2 ]. ACE2 (angiotensin-converting enzyme 2) [ 3 – 5...
View articletitled, Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition
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Angiotensin-(1–7), an alternative metabolite of the renin–angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat

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John S. Lubel, Chandana B. Herath, Jorge Tchongue, Josephine Grace, Zhiyuan Jia, Karen Spencer, David Casley, Peter Crowley, William Sievert, Louise M. Burrell, Peter W. Angus
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (11): 375–386.
https://doi.org/10.1042/CS20080647
Published: 14 September 2009
...John S. Lubel; Chandana B. Herath; Jorge Tchongue; Josephine Grace; Zhiyuan Jia; Karen Spencer; David Casley; Peter Crowley; William Sievert; Louise M. Burrell; Peter W. Angus Ang-(1–7) (angiotensin-1–7), a peptide product of the recently described ACE (angiotensin-converting enzyme) homologue ACE2...
View articletitled, Angiotensin-(1–7), an alternative metabolite of the renin–angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat
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Includes: Supplementary data