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Keywords: Atherosclerosis
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Articles
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (1): 1–21.
Published: 05 January 2024
... 05 12 2023 © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ASBT atherosclerosis Bile acid NTCP Nederlandse...
Articles
Nuria Dolade, Sandra Rayego-Mateos, Alicia Garcia-Carrasco, Maryse Guerin, Jose-Luis Martín-Ventura, Marta Ruiz-Ortega, Pierre-Louis Tharaux, Jose Manuel Valdivielso
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1409–1429.
Published: 13 September 2023
... cardiovascular disease is accelerated in CKD, but specific CKD-related risk factors for atherosclerosis are unknown. Methods: CKD patients from the NEFRONA study were used. We performed mRNA array from blood of patients free from atheroma plaque at baseline, with ( n =10) and without ( n =10) de novo...
Includes: Supplementary data
Articles
Lauren T. May, Belinda A. Bartolo, David G. Harrison, Tomasz Guzik, Grant R. Drummond, Gemma A. Figtree, Rebecca H. Ritchie, Kerry-Anne Rye, Judy B. de Haan
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1731–1758.
Published: 02 December 2022
... pharmacotherapies to treat CVD, particularly atherosclerosis. Effective mechanism-informed development and translation of new drugs requires a deep understanding of the known and currently unknown biological mechanisms underpinning atherosclerosis, accompanied by optimization of traditional drug discovery...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... associated with a local dysregulated metabolic response. Thus, recent studies show that metabolites are more than just fuels in their metabolic pathways, and they can act as modulators of vascular inflammation and atherosclerosis. In this review article, we describe the most common immunometabolic pathways...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
...Kurt Brassington; Stavros Selemidis; Steven Bozinovski; Ross Vlahos Chronic obstructive pulmonary disease (COPD) and atherosclerosis are chronic irreversible diseases, that share a number of common causative factors including cigarette smoking. Atherosclerosis drastically impairs blood flow...
Articles
Ellesandra C. Noye, Siroon Bekkering, Albert P. Limawan, Maria U. Nguyen, Lisa K. Widiasmoko, Hui Lu, Salvatore Pepe, Michael M. Cheung, Trevelyan R. Menheniott, Megan J. Wallace, Timothy J. Moss, David P. Burgner, Kirsty R. Short
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1859–1871.
Published: 04 August 2021
... inflammation has additive and deleterious effects on atherosclerosis in ApoE −/− mice. Here, we aimed to investigate whether innate immune training is a contributory inflammatory mechanism in this murine model of atherosclerosis. Methods: Bone marrow-derived macrophages and peritoneal macrophages were isolated...
Includes: Supplementary data
Articles
In Collection
Cardiovascular-Oncology
Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
Published: 20 July 2021
..., including hypertension, congestive heart failure, myocarditis and acceleration of atherosclerosis. Currently, VEGFI and ICI combination therapy is recommended for the treatment of advanced renal cell carcinoma (RCC) and has shown promising treatment efficacy in other tumour types as well. Consequently...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1557–1561.
Published: 30 June 2021
...: 10.1042/CS20201399). This important work demonstrates that PML, previously unrecognized as a participant in development of atherosclerosis, may represent a novel target for anti-atherosclerotic therapeutic modalities. Correspondence: Michael V. Autieri ( [email protected] ) * These authors...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
...Abdul Waheed Khan; Francesco Paneni; Karin A.M. Jandeleit-Dahm Atherosclerosis is a disease of large and medium arteries that can lead to life-threatening cerebrovascular and cardiovascular consequences such as heart failure and stroke and is a major contributor to cardiovascular-related mortality...
Articles
In Collection
Cardiovascular-Oncology
Leanne Mooney, Carl S. Goodyear, Tamir Chandra, Kristina Kirschner, Mhairi Copland, Mark C. Petrie, Ninian N. Lang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ageing atherosclerosis cardiovascular disease clonal haematopoiesis of indeterminate potential heart failure...
Articles
Weronika Karle, Samuel Becker, Philipp Stenzel, Christoph Knosalla, Günter Siegel, Oliver Baum, Andreas Zakrzewicz, Janine Berkholz
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 887–905.
Published: 09 April 2021
... can also act as a regulator of the inflammatory and fibroproliferative responses characteristic of atherosclerosis, we investigated whether PML is implicated in this disease. Immunoblotting, ELISA and immunohistochemistry showed a stronger expression of PML in segments of human atherosclerotic...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 447–463.
Published: 01 February 2021
...Ling-lin Qian; Jing-jing Ji; Jia-qi Guo; Yan-ping Wu; Gen-shan Ma; Yu-yu Yao Abnormal vascular smooth muscle cell (VSMC) proliferation is a critical step in the development of atherosclerosis. Serpina3c is a serine protease inhibitor (serpin) that plays a key role in metabolic diseases. The present...
Includes: Supplementary data
Articles
In Collection
Cardiovascular-Oncology
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
... 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis cardiac arrhythmia heart failure hypertension Tyrosine kinase...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1775–1799.
Published: 17 July 2020
...), and liver failure. With the exception of intrahepatic burden, cardiovascular disease (CVD) and especially atherosclerosis (AS) are common complications of NAFLD. Furthermore, CVD is a major cause of death in NAFLD patients. Additionally, AS is a metabolic disorder highly associated with NAFLD...
Articles
Manal Muin Fardoun, Dina Maaliki, Nabil Halabi, Rabah Iratni, Alessandra Bitto, Elias Baydoun, Ali H. Eid
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit...
Articles
Zemou Yu, Qing Peng, Songyue Li, Hongjun Hao, Jianwen Deng, Lingbing Meng, Zhiyuan Shen, Weiwei Yu, Ding Nan, Yu Bai, Yining Huang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (5): 439–458.
Published: 04 March 2020
...Zemou Yu; Qing Peng; Songyue Li; Hongjun Hao; Jianwen Deng; Lingbing Meng; Zhiyuan Shen; Weiwei Yu; Ding Nan; Yu Bai; Yining Huang Sphingolipids have been implicated in the etiology of atherosclerosis. The commonly used sphingolipid inhibitors, myriocin (a ceramide inhibitor) and d -PDMP ( d -threo...
Includes: Supplementary data
Articles
Yanan Zhang, Zhongzhou Guo, Tongwei Wu, Jichen Liu, Bin Zhang, Wenyan Lai, Wenwei Tu, Zhigang Guo, Tiantian Luo
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 273–287.
Published: 29 January 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 acute myocardial infarction Atherosclerosis DNA methylation inflammation reverse cholesterol transport SULT2B1b Atherosclerosis (AS) is the most common underlying cause...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
... miRNA biomarker development. Atherosclerosis is a progressive chronic inflammatory process that begins with an insult to the endothelial cell (EC) lining and eventually leads to the development of a fibrofatty lesion in the arterial wall [ 40–42 ]. Developing over the course of decades...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (1): 3–13.
Published: 03 January 2020
... with the nearby vessel wall to regulate vascular function. Cross-talk between perivascular adipocytes and the cells in the blood vessel wall is vital for normal vascular function and becomes perturbed in diseases such as atherosclerosis. Perivascular adipocytes surrounding coronary arteries may be primed...
Articles
Kengo Sato, Hayami Yoshizawa, Tomomi Seki, Remina Shirai, Tomoyuki Yamashita, Taisuke Okano, Koichiro Shibata, Miyu J. Wakamatsu, Yusaku Mori, Toshisuke Morita, Taka-aki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1779–1796.
Published: 20 August 2019
... inducing apoptosis. In the Apoe −/− mice, a 4-week infusion of chemerin-9 significantly decreased the areas of aortic atherosclerotic lesions by reducing intraplaque macrophage and SMC contents. Our results indicate that chemerin-9 prevents atherosclerosis. Therefore, the development of chemerin analogs...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1581–1585.
Published: 22 July 2019
...B Sumayyah H Sokeechand; Bernardo L Trigatti Atherosclerosis is a chronic inflammatory disease and a major driver of heart attack and stroke. Atherosclerosis development is driven by the infiltration of leukocytes, including monocytes and neutrophils, among other inflammatory cells into the artery...
Articles
Yu Sun, Juan Guan, Yunfeng Hou, Fei Xue, Wei Huang, Wencheng Zhang, Yun Zhang, Cheng Zhang, Jianmin Yang
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (11): 1215–1228.
Published: 03 June 2019
...Yu Sun; Juan Guan; Yunfeng Hou; Fei Xue; Wei Huang; Wencheng Zhang; Yun Zhang; Cheng Zhang; Jianmin Yang Background: Although junctional adhesion molecule-like protein (JAML) has recently been implicated in leukocyte recruitment during inflammation and wound repair, its role in atherosclerosis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (6): 763–776.
Published: 19 March 2019
... therapeutic targets. Herein, we briefly review how sphingolipids are implicated in the progression of atherosclerosis and related diseases, and then we discuss the potential therapy options by targetting several key enzymes in sphingolipid metabolism. Correspondence: Yining Huang ( [email protected]...
Articles
Yuki Sato, Rena Watanabe, Nozomi Uchiyama, Nana Ozawa, Yui Takahashi, Remina Shirai, Kengo Sato, Yusaku Mori, Takaaki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (23): 2493–2507.
Published: 05 December 2018
..., and plasma glucose level in ApoE −/− mice. These results indicate the inhibitory effects of vasostatin-1 against atherogenesis. The present study provided the first evidence that vasostatin-1 may serve as a novel therapeutic target for atherosclerosis. Correspondence: Takuya Watanabe ( watanabe...
Includes: Supplementary data
Articles
Alessandra Magenta, Sara Sileno, Marco D’Agostino, Francesca Persiani, Sara Beji, Alessandra Paolini, Daniele Camilli, Alessandro Platone, Maurizio C. Capogrossi, Sergio Furgiuele
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2423–2436.
Published: 22 November 2018
... from earlier revascularisation. Nowadays, different biomarkers of plaque instability have been unravelled, among these miRNAs are promising tools for the diagnosis and treatment of atherosclerosis. Inflammation, reactive oxygen species (ROS) and endothelial dysfunction play a key role in unstable...
Includes: Supplementary data
Articles
Dragana Dragoljevic, Marit Westerterp, Camilla Bertuzzo Veiga, Prabhakara Nagareddy, Andrew J. Murphy
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1889–1899.
Published: 05 September 2018
..., such as obesity, diabetes, hypercholesteraemia, and rheumatoid arthritis (RA), have been shown to alter myelopoiesis to exacerbate atherosclerosis. Genetic evidence has emerged in humans with the discovery of clonal haematopoiesis of indeterminate potential (CHIP), resulting in a disordered haematopoietic system...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1875–1888.
Published: 05 September 2018
... where it triggers monocyte and T-cell arrest and their subsequent transmigration [ 115 , 116 ]. The importance of CCL5 in vascular inflammation is supported by the fact that circulating levels of CCL5 were found to be elevated in different pathological conditions including atherosclerosis [ 117...
Articles
Michael H. Chiu, Bobak Heydari, Zarah Batulan, Nadia Maarouf, Vinita Subramanya, Karin Schenck-Gustafsson, Edward R. O’Brien
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1937–1952.
Published: 05 September 2018
...). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Correspondence: Edward R. O’Brien ( [email protected] ) 22 01 2018 07 08 2018 10 08 2018 atherosclerosis biomarkers coronary artery disease imaging menopause women...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1811–1836.
Published: 30 August 2018
...), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1509–1512.
Published: 23 July 2018
...Neil MacRitchie; Pasquale Maffia The hallmark features of atherosclerosis include accumulation of low-density lipoprotein (LDL) carrying cholesterol in the vessel wall, formation of lipid-laden foam cells, and the creation of a pro-inflammatory microenvironment. To date, no effective treatments...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
... in specific groups of diseases: cardiovascular, cancer, and neurodegenerative. These results indicate association with the disease states, although not yet clear-cut to yield specific biomarkers. We also highlight mechanisms whereby thiol pools affect atherosclerosis pathophysiology. Overall, it is unlikely...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
...Glaucylara Reis Geovanini; Peter Libby The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis and its complications has gained considerable attention, but has not yet entered clinical practice. Experimental work has elucidated molecular and cellular pathways...
Articles
Cheng Zhang, Juan-Juan Qin, Fu-Han Gong, Jing-Jing Tong, Wen-Lin Cheng, Haiping Wang, Yan Zhang, Xueyong Zhu, Zhi-Gang She, Hao Xia, Li-Hua Zhu
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (11): 1199–1213.
Published: 15 June 2018
... processes, and immune responses. The aim of the present study was to assess whether mindin contributes to the development of atherosclerosis. A significant up-regulation of Mindin expression was observed in the serum, arteries and atheromatous plaques of ApoE −/− mice after high-fat diet treatment. Mindin...
Includes: Supplementary data
Articles
Allison B. Reiss, Neal Shah, Dalia Muhieddine, Juan Zhen, Jennifer Yudkevich, Lora J. Kasselman, Joshua DeLeon
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (11): 1135–1153.
Published: 09 June 2018
... missing 14 amino acids at the C terminal end and instead of being secreted, this protein is retained in the endoplasmic reticulum [ 37 , 40 ]. atherosclerosis cholesterol hyperlipidemia low-density lipoprotein PCSK9 inhibitor Discovered in 2003, proprotein convertase subtilisin/kexin...
Articles
Surya Ramachandran, Vinitha Anandan, V. R. Kutty, Ajit Mullasari, M. Radhakrishna Pillai, Cheranellore Chandrasekharan Kartha
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 719–738.
Published: 30 March 2018
...Surya Ramachandran; Vinitha Anandan; V. R. Kutty; Ajit Mullasari; M. Radhakrishna Pillai; Cheranellore Chandrasekharan Kartha Growing evidence implicates cyclophilin A secreted by vascular wall cells and monocytes as a key mediator in atherosclerosis. Cyclophilin A in addition to its proliferative...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
... microbiome, obesity, free radical-induced lipoprotein oxidation, and retention in the arterial wall, subsequent foam cell formation, and atherosclerosis, (iii) mechanism by which stone forming risk factors such as oxalate, calcium, uric acid, and infection contribute toward CVDs, and (iv) how CVD risk...
Articles
Ernesto Martín-Núñez, Javier Donate-Correa, Ángel López-Castillo, Alejandro Delgado-Molinos, Carla Ferri, Sergio Rodríguez-Ramos, Purificación Cerro, Nayra Pérez-Delgado, Victoria Castro, Carolina Hernández-Carballo, Carmen Mora-Fernández, Juan F. Navarro-González
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (21): 2601–2609.
Published: 25 October 2017
...Ernesto Martín-Núñez; Javier Donate-Correa; Ángel López-Castillo; Alejandro Delgado-Molinos; Carla Ferri; Sergio Rodríguez-Ramos; Purificación Cerro; Nayra Pérez-Delgado; Victoria Castro; Carolina Hernández-Carballo; Carmen Mora-Fernández; Juan F. Navarro-González Atherosclerosis is a chronic...
Articles
Narges Yazdekhasti, Corinna Brandsch, Frank Hirche, Julia Kühn, Anke Schloesser, Tuba Esatbeyoglu, Patricia Huebbe, Siegfried Wolffram, Gerald Rimbach, Gabriele I. Stangl
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (20): 2549–2560.
Published: 13 October 2017
... health benefits. Here, we studied the impact of chocolate liquor on vascular lesion development and plaque composition in a mouse model of atherosclerosis. Apolipoprotein E (apoE)-knockout mice were assigned to two groups and fed a Western diet that contained 250 g/kg of either chocolate liquor...
Includes: Supplementary data
Articles
Dawn Thompson, Nicola Morrice, Louise Grant, Samantha Le Sommer, Emma K. Lees, Nimesh Mody, Heather M. Wilson, Mirela Delibegovic
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (20): 2489–2501.
Published: 29 September 2017
...Dawn Thompson; Nicola Morrice; Louise Grant; Samantha Le Sommer; Emma K. Lees; Nimesh Mody; Heather M. Wilson; Mirela Delibegovic Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence...
Includes: Supplementary data
Articles
Zhou Jiang, Juan-Juan Qin, Yaxing Zhang, Wen-Lin Cheng, Yan-Xiao Ji, Fu-Han Gong, Xue-Yong Zhu, Yan Zhang, Zhi-Gang She, Zan Huang, Hongliang Li
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2275–2288.
Published: 10 August 2017
...Zhou Jiang; Juan-Juan Qin; Yaxing Zhang; Wen-Lin Cheng; Yan-Xiao Ji; Fu-Han Gong; Xue-Yong Zhu; Yan Zhang; Zhi-Gang She; Zan Huang; Hongliang Li Atherosclerosis is a chronic inflammatory disease. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is associated with the pathological processes...
Articles
Mamoru Satoh, Takahito Nasu, Yuji Takahashi, Takuya Osaki, Sho Hitomi, Yoshihiro Morino, Motoyuki Nakamura
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2007–2017.
Published: 13 July 2017
.... In conclusion, elevated levels of miR-23a play an important role in coronary atherosclerosis via down-regulated TRF2, and may provide important prognostic information in patients with CAD. Additionally, aggressive LLT may prevent telomere erosion via down-regulated miR-23a . Correspondence: Mamoru Satoh...
Articles
Carolina N. França, Maria C.O. Izar, Marinella N.S. Hortêncio, Jônatas B. do Amaral, Carlos E.S. Ferreira, Izabela D. Tuleta, Francisco A.H. Fonseca
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1215–1224.
Published: 31 May 2017
... in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2101–2104.
Published: 11 October 2016
... pathway to exacerbate development of atherosclerosis in ApoE-/- mice. They further demonstrate that ApoE-/- mice transplanted with visceral adipose tissue in which JNK has been inactivated display less systemic inflammation and develop significantly less atherosclerosis compared with control mice...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2087–2100.
Published: 11 October 2016
...Kelvin H.M. Kwok; Kenneth K.Y. Cheng; Ruby L.C. Hoo; Dewei Ye; Aimin Xu; Karen S.L. Lam Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However...
Includes: Supplementary data
Articles
Elyse Di Marco, Stephen P. Gray, Phyllis Chew, Kit Kennedy, Mark E. Cooper, Harald H.H.W. Schmidt, Karin A.M. Jandeleit-Dahm
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
...Elyse Di Marco; Stephen P. Gray; Phyllis Chew; Kit Kennedy; Mark E. Cooper; Harald H.H.W. Schmidt; Karin A.M. Jandeleit-Dahm Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers...
Includes: Supplementary data
Articles
Stacy Robertson, Gonzalo J. Martínez, Cloe A. Payet, Jennifer Y. Barraclough, David S. Celermajer, Christina Bursill, Sanjay Patel
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1237–1246.
Published: 13 June 2016
...Stacy Robertson; Gonzalo J. Martínez; Cloe A. Payet; Jennifer Y. Barraclough; David S. Celermajer; Christina Bursill; Sanjay Patel Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1065–1074.
Published: 23 May 2016
... will need to include genotype in conjunction with the treatment goal (symptom relief), consideration of other medications and environmental factors. 17 β-oestradiol atherosclerosis carotid intima-medial thickness conjugated equine oestrogens coronary artery calcification Over the last...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (8): 551–563.
Published: 08 March 2016
... has matured, so has the understanding that sex differences are apparent even in the electrical system of the heart. The basic electrophysiology of the heart differs between women and men, as do the clinical manifestations of arrhythmias. atherosclerosis heart failure heart rhythm sex...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
... has revealed the participation of CXCR3 and its ligands in multiple cardiovascular diseases (CVDs) of different aetiologies including atherosclerosis, hypertension, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD). CXCR3...
Articles
Kate McCloskey, David Burgner, John B. Carlin, Michael R. Skilton, Michael Cheung, Terence Dwyer, Peter Vuillermin, Anne-Louise Ponsonby, on behalf of the BIS investigator group
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (6): 443–450.
Published: 04 February 2016
... and cardiovascular disease, but there are limited prospective data regarding the association between infant adiposity, postnatal growth and early cardiovascular parameters. Increased aortic intima-media thickness (aortic IMT) is an intermediate phenotype of early atherosclerosis. The aim of the present study...
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