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Keywords: Atherosclerosis
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Articles
Clin Sci (Lond) (2021) 135 (15): 1859–1871.
Published: 04 August 2021
... inflammation has additive and deleterious effects on atherosclerosis in ApoE −/− mice. Here, we aimed to investigate whether innate immune training is a contributory inflammatory mechanism in this murine model of atherosclerosis. Methods: Bone marrow-derived macrophages and peritoneal macrophages were isolated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
Published: 20 July 2021
..., including hypertension, congestive heart failure, myocarditis and acceleration of atherosclerosis. Currently, VEGFI and ICI combination therapy is recommended for the treatment of advanced renal cell carcinoma (RCC) and has shown promising treatment efficacy in other tumour types as well. Consequently...
Articles
Clin Sci (Lond) (2021) 135 (13): 1557–1561.
Published: 30 June 2021
...: 10.1042/CS20201399). This important work demonstrates that PML, previously unrecognized as a participant in development of atherosclerosis, may represent a novel target for anti-atherosclerotic therapeutic modalities. Correspondence: Michael V. Autieri ( mautieri@temple.edu ) * These authors...
Articles
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
...Abdul Waheed Khan; Francesco Paneni; Karin A.M. Jandeleit-Dahm Atherosclerosis is a disease of large and medium arteries that can lead to life-threatening cerebrovascular and cardiovascular consequences such as heart failure and stroke and is a major contributor to cardiovascular-related mortality...
Articles
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ageing atherosclerosis cardiovascular disease clonal haematopoiesis of indeterminate potential heart failure Cardiovascular disease (CVD) and cancer are the two leading causes of deaths...
Articles
Clin Sci (Lond) (2021) 135 (7): 887–905.
Published: 09 April 2021
... can also act as a regulator of the inflammatory and fibroproliferative responses characteristic of atherosclerosis, we investigated whether PML is implicated in this disease. Immunoblotting, ELISA and immunohistochemistry showed a stronger expression of PML in segments of human atherosclerotic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (3): 447–463.
Published: 01 February 2021
...Ling-lin Qian; Jing-jing Ji; Jia-qi Guo; Yan-ping Wu; Gen-shan Ma; Yu-yu Yao Abnormal vascular smooth muscle cell (VSMC) proliferation is a critical step in the development of atherosclerosis. Serpina3c is a serine protease inhibitor (serpin) that plays a key role in metabolic diseases. The present...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
... 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis cardiac arrhythmia heart failure hypertension Tyrosine kinase...
Articles
Clin Sci (Lond) (2020) 134 (13): 1775–1799.
Published: 17 July 2020
...), and liver failure. With the exception of intrahepatic burden, cardiovascular disease (CVD) and especially atherosclerosis (AS) are common complications of NAFLD. Furthermore, CVD is a major cause of death in NAFLD patients. Additionally, AS is a metabolic disorder highly associated with NAFLD...
Articles
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit...
Articles
Clin Sci (Lond) (2020) 134 (5): 439–458.
Published: 04 March 2020
...Zemou Yu; Qing Peng; Songyue Li; Hongjun Hao; Jianwen Deng; Lingbing Meng; Zhiyuan Shen; Weiwei Yu; Ding Nan; Yu Bai; Yining Huang Sphingolipids have been implicated in the etiology of atherosclerosis. The commonly used sphingolipid inhibitors, myriocin (a ceramide inhibitor) and d -PDMP ( d -threo...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 273–287.
Published: 29 January 2020
... of the Biochemical Society 2020 acute myocardial infarction Atherosclerosis DNA methylation inflammation reverse cholesterol transport SULT2B1b Atherosclerosis (AS) is the most common underlying cause of ischaemic heart disease and continues to be a leading cause of deaths worldwide [ 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
... been made regarding miRNA functions in atherosclerosis through mouse models of disease and cell culture studies, which have revealed important miRNA-regulated activities in ECs, VSMCs, and monocytes/macrophages. A role for miRNAs in ECs has been demonstrated from studies of atheroprone ApoE −/− mice...
Articles
Clin Sci (Lond) (2020) 134 (1): 3–13.
Published: 03 January 2020
... with the nearby vessel wall to regulate vascular function. Cross-talk between perivascular adipocytes and the cells in the blood vessel wall is vital for normal vascular function and becomes perturbed in diseases such as atherosclerosis. Perivascular adipocytes surrounding coronary arteries may be primed...
Articles
Clin Sci (Lond) (2019) 133 (16): 1779–1796.
Published: 20 August 2019
... inducing apoptosis. In the Apoe −/− mice, a 4-week infusion of chemerin-9 significantly decreased the areas of aortic atherosclerotic lesions by reducing intraplaque macrophage and SMC contents. Our results indicate that chemerin-9 prevents atherosclerosis. Therefore, the development of chemerin analogs...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1581–1585.
Published: 22 July 2019
...B Sumayyah H Sokeechand; Bernardo L Trigatti Atherosclerosis is a chronic inflammatory disease and a major driver of heart attack and stroke. Atherosclerosis development is driven by the infiltration of leukocytes, including monocytes and neutrophils, among other inflammatory cells into the artery...
Articles
Clin Sci (Lond) (2019) 133 (11): 1215–1228.
Published: 03 June 2019
...Yu Sun; Juan Guan; Yunfeng Hou; Fei Xue; Wei Huang; Wencheng Zhang; Yun Zhang; Cheng Zhang; Jianmin Yang Background: Although junctional adhesion molecule-like protein (JAML) has recently been implicated in leukocyte recruitment during inflammation and wound repair, its role in atherosclerosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (6): 763–776.
Published: 19 March 2019
... therapeutic targets. Herein, we briefly review how sphingolipids are implicated in the progression of atherosclerosis and related diseases, and then we discuss the potential therapy options by targetting several key enzymes in sphingolipid metabolism. Atherosclerosis Ceramide Sphingolipids...
Articles
Clin Sci (Lond) (2018) 132 (23): 2493–2507.
Published: 05 December 2018
..., and plasma glucose level in ApoE −/− mice. These results indicate the inhibitory effects of vasostatin-1 against atherogenesis. The present study provided the first evidence that vasostatin-1 may serve as a novel therapeutic target for atherosclerosis. Correspondence: Takuya Watanabe ( watanabe...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2423–2436.
Published: 22 November 2018
... from earlier revascularisation. Nowadays, different biomarkers of plaque instability have been unravelled, among these miRNAs are promising tools for the diagnosis and treatment of atherosclerosis. Inflammation, reactive oxygen species (ROS) and endothelial dysfunction play a key role in unstable...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (17): 1889–1899.
Published: 05 September 2018
..., such as obesity, diabetes, hypercholesteraemia, and rheumatoid arthritis (RA), have been shown to alter myelopoiesis to exacerbate atherosclerosis. Genetic evidence has emerged in humans with the discovery of clonal haematopoiesis of indeterminate potential (CHIP), resulting in a disordered haematopoietic system...
Articles
Clin Sci (Lond) (2018) 132 (17): 1875–1888.
Published: 05 September 2018
... on behalf of the Biochemical Society 2018 atherosclerosis microRNA platelet adhesion and activation Platelets are discoid anuclear cells produced by megakaryocytes; while the bone marrow is the classical and most important site of proplatelet formation and platelet biogenesis [ 1...
Articles
Clin Sci (Lond) (2018) 132 (17): 1937–1952.
Published: 05 September 2018
...: Edward R. O’Brien ( ermobrie@ucalgary.ca ) 22 01 2018 07 08 2018 10 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis biomarkers coronary artery disease imaging menopause women...
Articles
Clin Sci (Lond) (2018) 132 (16): 1811–1836.
Published: 30 August 2018
...), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads...
Articles
Clin Sci (Lond) (2018) 132 (14): 1509–1512.
Published: 23 July 2018
...Neil MacRitchie; Pasquale Maffia The hallmark features of atherosclerosis include accumulation of low-density lipoprotein (LDL) carrying cholesterol in the vessel wall, formation of lipid-laden foam cells, and the creation of a pro-inflammatory microenvironment. To date, no effective treatments...
Articles
Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
... in specific groups of diseases: cardiovascular, cancer, and neurodegenerative. These results indicate association with the disease states, although not yet clear-cut to yield specific biomarkers. We also highlight mechanisms whereby thiol pools affect atherosclerosis pathophysiology. Overall, it is unlikely...
Articles
Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
...Glaucylara Reis Geovanini; Peter Libby The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis and its complications has gained considerable attention, but has not yet entered clinical practice. Experimental work has elucidated molecular and cellular pathways...
Articles
Clin Sci (Lond) (2018) 132 (11): 1199–1213.
Published: 15 June 2018
... processes, and immune responses. The aim of the present study was to assess whether mindin contributes to the development of atherosclerosis. A significant up-regulation of Mindin expression was observed in the serum, arteries and atheromatous plaques of ApoE −/− mice after high-fat diet treatment. Mindin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (11): 1135–1153.
Published: 09 June 2018
... of the Biochemical Society 2018 atherosclerosis cholesterol hyperlipidemia low-density lipoprotein PCSK9 inhibitor Discovered in 2003, proprotein convertase subtilisin/kexin type 9 (PCSK9) is a positive regulator of plasma low-density lipoprotein (LDL) [ 1 ]. It behaves as a chaperone to increase...
Articles
Clin Sci (Lond) (2018) 132 (6): 719–738.
Published: 30 March 2018
...Surya Ramachandran; Vinitha Anandan; V. R. Kutty; Ajit Mullasari; M. Radhakrishna Pillai; Cheranellore Chandrasekharan Kartha Growing evidence implicates cyclophilin A secreted by vascular wall cells and monocytes as a key mediator in atherosclerosis. Cyclophilin A in addition to its proliferative...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
... microbiome, obesity, free radical-induced lipoprotein oxidation, and retention in the arterial wall, subsequent foam cell formation, and atherosclerosis, (iii) mechanism by which stone forming risk factors such as oxalate, calcium, uric acid, and infection contribute toward CVDs, and (iv) how CVD risk...
Articles
Clin Sci (Lond) (2017) 131 (21): 2601–2609.
Published: 25 October 2017
...Ernesto Martín-Núñez; Javier Donate-Correa; Ángel López-Castillo; Alejandro Delgado-Molinos; Carla Ferri; Sergio Rodríguez-Ramos; Purificación Cerro; Nayra Pérez-Delgado; Victoria Castro; Carolina Hernández-Carballo; Carmen Mora-Fernández; Juan F. Navarro-González Atherosclerosis is a chronic...
Articles
Clin Sci (Lond) (2017) 131 (20): 2549–2560.
Published: 13 October 2017
... health benefits. Here, we studied the impact of chocolate liquor on vascular lesion development and plaque composition in a mouse model of atherosclerosis. Apolipoprotein E (apoE)-knockout mice were assigned to two groups and fed a Western diet that contained 250 g/kg of either chocolate liquor...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (20): 2489–2501.
Published: 29 September 2017
...Dawn Thompson; Nicola Morrice; Louise Grant; Samantha Le Sommer; Emma K. Lees; Nimesh Mody; Heather M. Wilson; Mirela Delibegovic Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (17): 2275–2288.
Published: 10 August 2017
...Zhou Jiang; Juan-Juan Qin; Yaxing Zhang; Wen-Lin Cheng; Yan-Xiao Ji; Fu-Han Gong; Xue-Yong Zhu; Yan Zhang; Zhi-Gang She; Zan Huang; Hongliang Li Atherosclerosis is a chronic inflammatory disease. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is associated with the pathological processes...
Articles
Clin Sci (Lond) (2017) 131 (15): 2007–2017.
Published: 13 July 2017
.... In conclusion, elevated levels of miR-23a play an important role in coronary atherosclerosis via down-regulated TRF2, and may provide important prognostic information in patients with CAD. Additionally, aggressive LLT may prevent telomere erosion via down-regulated miR-23a . Correspondence: Mamoru Satoh...
Articles
Clin Sci (Lond) (2017) 131 (12): 1215–1224.
Published: 31 May 2017
... in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...
Articles
Clin Sci (Lond) (2016) 130 (22): 2101–2104.
Published: 11 October 2016
... pathway to exacerbate development of atherosclerosis in ApoE-/- mice. They further demonstrate that ApoE-/- mice transplanted with visceral adipose tissue in which JNK has been inactivated display less systemic inflammation and develop significantly less atherosclerosis compared with control mice...
Articles
Clin Sci (Lond) (2016) 130 (22): 2087–2100.
Published: 11 October 2016
...Kelvin H.M. Kwok; Kenneth K.Y. Cheng; Ruby L.C. Hoo; Dewei Ye; Aimin Xu; Karen S.L. Lam Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
...Elyse Di Marco; Stephen P. Gray; Phyllis Chew; Kit Kennedy; Mark E. Cooper; Harald H.H.W. Schmidt; Karin A.M. Jandeleit-Dahm Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (14): 1237–1246.
Published: 13 June 2016
...Stacy Robertson; Gonzalo J. Martínez; Cloe A. Payet; Jennifer Y. Barraclough; David S. Celermajer; Christina Bursill; Sanjay Patel Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1065–1074.
Published: 23 May 2016
... will need to include genotype in conjunction with the treatment goal (symptom relief), consideration of other medications and environmental factors. 17 β-oestradiol atherosclerosis carotid intima-medial thickness conjugated equine oestrogens coronary artery calcification Over the last...
Articles
Clin Sci (Lond) (2016) 130 (8): 551–563.
Published: 08 March 2016
... © 2016 Authors; published by Portland Press Limited 2016 atherosclerosis heart failure heart rhythm sex differences women Despite the fact that cardiovascular disease is the leading cause of death for women, they have been significantly underrepresented in cardiovascular research...
Articles
Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
... has revealed the participation of CXCR3 and its ligands in multiple cardiovascular diseases (CVDs) of different aetiologies including atherosclerosis, hypertension, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD). CXCR3...
Articles
Clin Sci (Lond) (2016) 130 (6): 443–450.
Published: 04 February 2016
... and cardiovascular disease, but there are limited prospective data regarding the association between infant adiposity, postnatal growth and early cardiovascular parameters. Increased aortic intima-media thickness (aortic IMT) is an intermediate phenotype of early atherosclerosis. The aim of the present study...
Articles
Clin Sci (Lond) (2016) 130 (3): 127–150.
Published: 17 December 2015
...Smriti Murali Krishna; Safraz Mohamed Omer; Jonathan Golledge Peripheral arterial disease (PAD) usually results from atherosclerosis and associated thrombosis and limits blood supply to the lower limbs. Common presenting symptoms include intermittent claudication (IC), rest pain and tissue loss...
Articles
Clin Sci (Lond) (2015) 129 (12): 1151–1161.
Published: 30 October 2015
... in hypercholesterolaemia, and that NR4A1 expression reduces hypercholesterolaemia-induced inflammation. • Strong evidence suggests a synergy between inflammation and hypercholesterolaemia in atherosclerosis. NR4A1, a key regulator of inflammation, is closely associated with lipid levels in vivo . However...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (8): 769–784.
Published: 29 July 2015
... of atherosclerosis are in early life, a potential albeit largely unrecognized window of opportunity for early detection and treatment of subclinical cardiovascular disease. There are robust epidemiological data indicating that poor intrauterine growth and/or prematurity, and perinatal factors such as maternal...
Articles
Clin Sci (Lond) (2015) 129 (3): 259–269.
Published: 08 May 2015
... (extracellular vesicles) is involved in the pathogenesis of atherosclerosis. PCR and gene sequencing found the SRY gene fragment in plasma EVs from male, but not female, patients; EVs from male patients with CAD (coronary artery disease) had a higher SRY GCN (gene copy number) than healthy subjects. Additional...
Articles
Clin Sci (Lond) (2015) 129 (2): 93–105.
Published: 24 April 2015
.... Endothelial cell injury is regarded as the classic stimulus for the development of atherosclerotic lesions. In addition, the inflammatory process plays an important role in the aetiology of atherosclerosis. In particular, chronic inflammation plays a key role in coronary artery plaque instability...