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Keywords: Autophagy
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Articles

IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53

Shiyu Wang, Tingting Cheng, Xu Chen, Cong Zeng, Wei Qin, Yajing Xu
Journal: Clinical Science
Clin Sci (Lond) (2024) CS20241144.
https://doi.org/10.1042/CS20241144
Published: 23 September 2024
... unclear. Interferon (IFN)-γ, a pivotal proinflammatory cytokine, assumes a crucial role in regulating alloreactive T cell responses and plays a complex part in aGVHD development. IFN-γ has the capacity to induce autophagy, a vital catabolic process facilitating protein degradation, in various cell types...
View article titled, IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53
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Articles

Transferrin promotes chondrogenic differentiation in condylar growth through inducing autophagy via ULK1-ATG16L1 axis

Xi Wen, Yixiang Wang, Yan Gu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (18): 1431–1449.
https://doi.org/10.1042/CS20230544
Published: 21 September 2023
... of TF in condylar growth that TF protected chondrocytes from hypoxia-induced apoptosis and promoted chondrogenic differentiation through inducing autophagy via ULK1-ATG16L1 axis, which demonstrated that TF could be a novel growth factor of condylar growth and shed new light on developing treatment...
View article titled, Transferrin promotes chondrogenic differentiation in condylar growth through inducing <span class="search-highlight">autophagy</span> via ULK1-ATG16L1 axis
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Includes: Supplementary data
Articles

METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner

Jianfeng Liang, Hongshi Cai, Chen Hou, Fan Song, Yaoqi Jiang, Ziyi Wang, Danqi Qiu, Yue Zhu, Fang Wang, Dongsheng Yu, Jinsong Hou
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1373–1389.
https://doi.org/10.1042/CS20230219
Published: 05 September 2023
...Jianfeng Liang; Hongshi Cai; Chen Hou; Fan Song; Yaoqi Jiang; Ziyi Wang; Danqi Qiu; Yue Zhu; Fang Wang; Dongsheng Yu; Jinsong Hou N6-methyladenosine (m6A) plays crucial roles in tumorigenesis and autophagy. However, the underlying mechanisms mediated by m6A and autophagy in the malignant...
View article titled, METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the <span class="search-highlight">autophagy</span>-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner
Open the PDF for METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the <span class="search-highlight">autophagy</span>-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner in another window
Includes: Supplementary data
Articles

ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial–mesenchymal transition

Mengwen Wang, Yujian Liu, Lei Dai, Xiaodan Zhong, Wenjun Zhang, Yang Xie, Hesong Zeng, Hongjie Wang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1297–1309.
https://doi.org/10.1042/CS20230732
Published: 22 August 2023
... prove that ONX0914 could regulate autophagy activity both in vivo and vitro . Meanwhile, the protective effect of ONX0914 on TGFβ1 stimulated HUVECs could be abolished by 3-methyladenine (3MA) or hydroxychloroquine (CQ). All in all, our data highlight that inhibition of LMP7 with ONX0914 could...
View article titled, ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial–mesenchymal transition
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Includes: Supplementary data
Articles

Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome

Jinshan Xing, Gan Qiao, Xin Luo, Shuang Liu, Shaokun Chen, Geng Ye, Chunxiang Zhang, Jingyan Yi
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 453–468.
https://doi.org/10.1042/CS20220408
Published: 21 March 2023
... the proliferation of KGN and inhibited apoptosis. Moreover, FDX1 could regulate autophagy by influencing the autophagy proteins ATG3 and ATG7. Our results demonstrated that FDX1 plays a critical role in female folliculogenesis by mediating apoptosis, autophagy, and proliferation. Therefore, FDX1 may be a potential...
View article titled, Ferredoxin 1 regulates granulosa cell apoptosis and <span class="search-highlight">autophagy</span> in polycystic ovary syndrome
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Articles

Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Zhipeng Tao, Zhiyong Cheng
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 415–434.
https://doi.org/10.1042/CS20210519
Published: 21 March 2023
..., and PI3K in the joint regulation of autophagy and mitochondrial metabolism. Dysregulated insulin and estrogen signaling lead to metabolic diseases. This article reviews the up-to-date evidence that depicts the pathways of insulin signaling and estrogen-ER signaling in the regulation of metabolism...
View article titled, Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen
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Articles

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1873–1895.
https://doi.org/10.1042/CS20210447
Published: 06 August 2021
... in vivo . Moreover, BRG1 activated the Wnt/β-catenin pathway, which further inhibited autophagy. Pharmacologic inhibition of the Wnt/β-catenin pathway (ICG-001) or rapamycin (RAPA)-mediated activation of autophagy effectively blocked BRG1-induced tubular senescence and fibrotic responses, while...
View article titled, Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt&#x2F;β-catenin&#x2F;<span class="search-highlight">autophagy</span> axis
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Includes: Supplementary data
Articles

Expression of Concern: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1675.
https://doi.org/10.1042/CS-20191235_EOC
Published: 06 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Autophagy Hepatic fibrosis NADPH oxidase...
View article titled, Expression of Concern: Alamandine attenuates hepatic fibrosis by regulating <span class="search-highlight">autophagy</span> induced by NOX4-dependent ROS
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Articles

The ER stress-autophagy axis: implications for cognitive dysfunction in diabetes mellitus

Qingzhang Zhu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1255–1258.
https://doi.org/10.1042/CS20200235
Published: 05 June 2020
...Qingzhang Zhu Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong et al. highlighted the critical...
View article titled, The ER stress-<span class="search-highlight">autophagy</span> axis: implications for cognitive dysfunction in diabetes mellitus
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Articles

Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Yun Huang, Yang Li, Anni Lou, Guo zhen Wang, Ye Hu, Yijie Zhang, Weichang Huang, Jun Wang, Yue Li, Xintao Zhu, Tingting Chen, Jiayi Lin, Ying Meng, Xu Li
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 853–869.
https://doi.org/10.1042/CS20191235
Published: 09 April 2020
... (ALA) protects against fibrosis by counteracting Ang II via the MAS-related G-protein coupled (MrgD) receptor, though the effects of alamandine on hepatic fibrosis remain unknown. Autophagy activated by reactive oxygen species (ROS) is a novel mechanism of hepatic fibrosis. However, whether autophagy...
View article titled, Alamandine attenuates hepatic fibrosis by regulating <span class="search-highlight">autophagy</span> induced by NOX4-dependent ROS
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Articles

Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model

Andressa Manfredini, Larissa Constantino, Milton Castro Pinto, Monique Michels, Henrique Burger, Luiza W. Kist, Milena Carvalho Silva, Lara Mezzari Gomes, Diogo Dominguini, Amanda Steckert, Carmen Simioni, Mauricio Bogo, Emílio Streck, Tatiana Barichello, João de Quevedo, Mervyn Singer, Cristiane Ritter, Felipe Dal-Pizzol
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (18): 1993–2004.
https://doi.org/10.1042/CS20190351
Published: 24 September 2019
... (autophagy activators), or n-saline (sham control) once a day on days 7–9 after the septic insult. Cognitive impairment was assessed by inhibitory avoidance and object recognition tests. Animals were killed 24 h, 3 and 10 days after sepsis with the hippocampus and prefrontal cortex removed to determine...
View article titled, Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model
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Includes: Supplementary data
Articles

Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Yujia Yuan, Younan Chen, Tianqing Peng, Lan Li, Wuzheng Zhu, Fei Liu, Shuyun Liu, Xingxing An, Ruixi Luo, Jingqiu Cheng, Jingping Liu, Yanrong Lu
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (15): 1759–1777.
https://doi.org/10.1042/CS20190672
Published: 14 August 2019
... complications. Despite adverse consequences of autophagy impairment on macrophage inflammation, the regulation of macrophage autophagy under hyperglycemic conditions is incompletely understood. Here, we report that the autophagy–lysosome system and mitochondrial function are impaired in streptozotocin (STZ...
View article titled, Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition
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Includes: Supplementary data
Articles

Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts autophagy

Tingting Zeng, Xiaoyi Wang, Wei Wang, Qiling Feng, Guojuan Lao, Ying Liang, Chuan Wang, Jing Zhou, Yuying Chen, Jing Liu, Haiqi Gao, Biyun Lan, Yuxi Wu, Yuting Han, Yanyan Liu, Hongxing Chen, Liyi Liu, Chuan Yang, Li Yan, Meng Ren, Kan Sun
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (9): CS20190008.
https://doi.org/10.1042/CS20190008
Published: 02 May 2019
... HUVECs (AGEs-sEVs) could inhibit collagen synthesis by activating autophagy of human skin fibroblasts. Additionally, treatment with AGEs-sEVs could delay the wound healing process in Sprague–Dawley (SD) rats. Further analysis indicated that miR-106b-5p was up-regulated in AGEs-sEVs and importantly...
View article titled, Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts <span class="search-highlight">autophagy</span>
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Includes: Supplementary data
Articles

Is there a role for autophagy in ascending aortopathy associated with tricuspid or bicuspid aortic valve?

Amalia Forte, Marilena Cipollaro, Marisa De Feo, Alessandro Della Corte
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (7): 805–819.
https://doi.org/10.1042/CS20181092
Published: 02 April 2019
...Amalia Forte; Marilena Cipollaro; Marisa De Feo; Alessandro Della Corte Autophagy is a conserved process by which cytoplasmatic elements are sequestered in vesicles and degraded after their fusion with lysosomes, thus recycling the precursor molecules. The autophagy-mediated removal of redundant...
View article titled, Is there a role for <span class="search-highlight">autophagy</span> in ascending aortopathy associated with tricuspid or bicuspid aortic valve?
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Articles

Involvement of serum amyloid A1 in the rupture of fetal membranes through induction of collagen I degradation

Wang-sheng Wang, Wen-jiao Li, Ya-wei Wang, Lu-yao Wang, Ya-bing Mi, Jiang-wen Lu, Yi Lu, Chu-yue Zhang, Kang Sun
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (3): 515–530.
https://doi.org/10.1042/CS20180950
Published: 12 February 2019
... levels in human amnion fibroblasts. These reductions were completely blocked only with inhibition of both matrix metalloproteases (MMPs) and autophagy. Consistently, SAA1 increased MMP-2/9 abundance and the markers for autophagic activation including autophagy related (ATG) 7 (ATG7) and the microtubule...
View article titled, Involvement of serum amyloid A1 in the rupture of fetal membranes through induction of collagen I degradation
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Includes: Supplementary data
Articles

Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy

Jinfang Bao, Yingfeng Shi, Min Tao, Na Liu, Shougang Zhuang, Weijie Yuan
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2299–2322.
https://doi.org/10.1042/CS20180563
Published: 02 November 2018
...Jinfang Bao; Yingfeng Shi; Min Tao; Na Liu; Shougang Zhuang; Weijie Yuan Autophagy has been identified as a cellular process of bulk degradation of cytoplasmic components and its persistent activation is critically involved in the renal damage induced by ureteral obstruction. However, the role...
View article titled, Pharmacological inhibition of <span class="search-highlight">autophagy</span> by 3-MA attenuates hyperuricemic nephropathy
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Includes: Supplementary data
Articles

TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injury

Magaiver Andrade-Silva, Marcos Antonio Cenedeze, Luiz Augusto Perandini, Raphael José Ferreira Felizardo, Ingrid Kazue Mizuno Watanabe, Juan Sebastian Henao Agudelo, Angela Castoldi, Giselle Martins Gonçalves, Clarice Silvia Taemi Origassa, Patricia Semedo, Meire Ioshie Hiyane, Orestes Foresto-Neto, Denise Maria Avancini Costa Malheiros, Marlene Antonia Reis, Clarice Kazue Fujihara, Roberto Zatz, Alvaro Pacheco-Silva, Niels Olsen Saraiva Câmara, Danilo Candido de Almeida
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1725–1739.
https://doi.org/10.1042/CS20170262
Published: 22 August 2018
... an important role. The activation of TLRs results in production of several inflammatory cytokines leading to further renal damage. In contrast, TLRs are key players on autophagy induction, which is associated with a protective function on cisplatin-induced AKI. Hence, the present study aimed to evaluate...
View article titled, TLR2 and TLR4 play opposite role in <span class="search-highlight">autophagy</span> associated with cisplatin-induced acute kidney injury
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Includes: Supplementary data
Articles

HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis

Jing Li, Chuxiong Zeng, Beishi Zheng, Chun Liu, Min Tang, Yan Jiang, Yizhong Chang, Weiping Song, Yingxin Wang, Changqing Yang
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1645–1667.
https://doi.org/10.1042/CS20180177
Published: 14 August 2018
...Jing Li; Chuxiong Zeng; Beishi Zheng; Chun Liu; Min Tang; Yan Jiang; Yizhong Chang; Weiping Song; Yingxin Wang; Changqing Yang High-mobility group box-1 (HMGB1) plays a context-dependent role in autophagy, which is required for hepatic stellate cells (HSCs) activation. However, the significance...
View article titled, HMGB1-induced <span class="search-highlight">autophagy</span> facilitates hepatic stellate cells activation: a new pathway in liver fibrosis
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Includes: Supplementary data
Articles

Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice

Fei-Juan Kong, Lei-Lei Ma, Jun-Jie Guo, Lin-Hao Xu, Yun Li, Shen Qu
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (1): 111–125.
https://doi.org/10.1042/CS20171432
Published: 11 January 2018
..., the underlying mechanisms are yet to be fully determined. Both endoplasmic reticulum (ER) stress and autophagy have been reported to modulate neuronal survival and death and be associated with several neurodegenerative diseases. Here, a streptozotocin-induced diabetic mouse model and primary cultured mouse...
View article titled, Endoplasmic reticulum stress&#x2F;<span class="search-highlight">autophagy</span> pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice
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Articles

DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy

Bin Zhou, Shaoqing Lei, Rui Xue, Yan Leng, Zhengyuan Xia, Zhong-Yuan Xia
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1161–1178.
https://doi.org/10.1042/CS20170052
Published: 22 May 2017
.... We hypothesized that decreased cardiac expression of DJ-1, a positive modulator of autophagy, compromises the effectiveness of IPO-induced cardioprotection in diabetic rats. Diabetic rats subjected to myocardial IR (30 min of coronary artery occlusion followed by 120 min of reperfusion) exhibited...
View article titled, DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of <span class="search-highlight">autophagy</span>
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Articles

VMP1-related autophagy induced by a fructose-rich diet in β-cells: its prevention by incretins

Bárbara Maiztegui, Verónica Boggio, Carolina L. Román, Luis E. Flores, Héctor Del Zotto, Alejandro Ropolo, Daniel Grasso, María I. Vaccaro, Juan J. Gagliardino
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (8): 673–687.
https://doi.org/10.1042/CS20170010
Published: 28 March 2017
...Bárbara Maiztegui; Verónica Boggio; Carolina L. Román; Luis E. Flores; Héctor Del Zotto; Alejandro Ropolo; Daniel Grasso; María I. Vaccaro; Juan J. Gagliardino The aim of the present study was to demonstrate the role of autophagy and incretins in the fructose-induced alteration of β-cell mass...
View article titled, VMP1-related <span class="search-highlight">autophagy</span> induced by a fructose-rich diet in β-cells: its prevention by incretins
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Articles

HMGB1-induced autophagy: a new pathway to maintain Treg function during chronic hepatitis B virus infection

Li-sha Cheng, Jing Li, Yun Liu, Fu-ping Wang, Si-qi Wang, Wei-min She, Sheng-di Wu, Xiao-long Qi, Yong-ping Zhou, Wei Jiang
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (5): 381–394.
https://doi.org/10.1042/CS20160704
Published: 15 February 2017
...) infection and has a context-dependent role in autophagy, a highly conserved self-digestive process in response to environmental stress. Recent mouse studies indicate that autophagy is highly active in regulatory T (Treg)-cells. In the present study, we evaluated spontaneous and induced autophagy...
View article titled, HMGB1-induced <span class="search-highlight">autophagy</span>: a new pathway to maintain Treg function during chronic hepatitis B virus infection
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Articles

Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes

Rikke Kruse, Andreas J.T. Pedersen, Jonas M. Kristensen, Stine J. Petersson, Jørgen F.P. Wojtaszewski, Kurt Højlund
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (1): 37–47.
https://doi.org/10.1042/CS20160736
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
View article titled, Intact initiation of <span class="search-highlight">autophagy</span> and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes
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Includes: Supplementary data
Articles

Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin

Cristina A. Teixeira, Maria do Rosário Almeida, Maria João Saraiva
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1665–1675.
https://doi.org/10.1042/CS20160075
Published: 08 August 2016
... the ability of small compounds in preventing and reversing TTR V30M deposition in transgenic mice gastrointestinal (GI) tract as well as lowering biomarkers associated with cellular stress and apoptotic mechanisms. In the present study we aimed to study TTR V30M aggregates effect in autophagy, a cellular...
View article titled, Impairment of <span class="search-highlight">autophagy</span> by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin
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Articles

Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux

Yuanna Ling, Guiming Chen, Yi Deng, Huixiong Tang, Long Ling, Xiaoming Zhou, Xudong Song, Pingzhen Yang, Yingfeng Liu, Zhiliang Li, Cong Zhao, Yufei Yang, Xianbao Wang, Masafumi Kitakaze, Yulin Liao, Aihua Chen
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
https://doi.org/10.1042/CS20160082
Published: 08 August 2016
... on myocardial I/R injury and autophagy. C57BL/6 mice underwent left coronary artery (LCA) occlusion and cultured neonatal rat cardiomyocytes (NRCs) subjected to hypoxia were treated with vehicle or PD during reperfusion or re-oxygenation. We noted that PD enhanced autophagy and decreased apoptosis during I/R...
View article titled, Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux
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Includes: Supplementary data
Articles

Mitochondrial health, the epigenome and healthspan

Miguel A. Aon, Sonia Cortassa, Magdalena Juhaszova, Steven J. Sollott
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (15): 1285–1305.
https://doi.org/10.1042/CS20160002
Published: 29 June 2016
... healthspan. Correspondence: Miguel A. Aon (email [email protected] ). 14 1 2016 15 4 2016 3 5 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 acetylation aging autophagy biogenesis caloric restriction...
View article titled, Mitochondrial health, the epigenome and healthspan
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Articles

Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice

Jingjing Zhang, Yanli Cheng, Junlian Gu, Shudong Wang, Shanshan Zhou, Yuehui Wang, Yi Tan, Wenke Feng, Yaowen Fu, Nicholas Mellen, Rui Cheng, Jianxing Ma, Chi Zhang, Zhanquan Li, Lu Cai
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (8): 625–641.
https://doi.org/10.1042/CS20150623
Published: 08 March 2016
... and FGF21-KO diabetic mice. Mechanistically, FF treatment prevented diabetes-impaired autophagy, reflected by increased microtubule-associated protein 1A/1B-light chain 3, in the wild-type diabetic mice but not in the FGF21-KO diabetic mice. Studies with H9C2 cells in vitro demonstrated that exposure...
View article titled, Fenofibrate increases cardiac <span class="search-highlight">autophagy</span> via FGF21&#x2F;SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice
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Includes: Supplementary data
Articles

Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy

Yee Kwan Chan, Hye Kyoung Sung, Gary Sweeney
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (10): 851–862.
https://doi.org/10.1042/CS20150075
Published: 28 August 2015
... Press Limited 2015 24p3 autophagy cardiomyopathy ER stress heart failure iron deficiency iron overload lipocalin 2 (Lcn2) mitochondrial dysfunction NGAL oxidative stress In recent years there have been several clinical trials to test whether administration of intravenous iron...
View article titled, Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy
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Articles

Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes

Sebastiano Sciarretta, Derek Yee, Paul Ammann, Narayani Nagarajan, Massimo Volpe, Giacomo Frati, Junichi Sadoshima
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (7): 387–403.
https://doi.org/10.1042/CS20140336
Published: 09 December 2014
... pathways and regulate physiological cellular functions. It is now well-established that ROS regulate autophagy, an intracellular degradation process. However, the signalling mechanisms through which ROS modulate autophagy in a regulated manner have only been minimally clarified. NADPH oxidase (Nox) enzymes...
View article titled, Role of NADPH oxidase in the regulation of <span class="search-highlight">autophagy</span> in cardiomyocytes
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Articles

(Pro)renin receptor and V-ATPase: from Drosophila to humans

Anthony Rousselle, Gabin Sihn, Martijn Rotteveel, Michael Bader
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (8): 529–536.
https://doi.org/10.1042/CS20130307
Published: 17 December 2013
... in Xenopus and Drosophila have revealed an essential role of this association to promote the canonical and non-canonical Wnt signalling pathways, whereas studies with tissue-specific gene deletion have pointed out a role in autophagy. The present review aims to summarize recent findings on the cellular...
View article titled, (Pro)renin receptor and V-ATPase: from Drosophila to humans
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Articles

Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP

Bo-Shi Wang, Yi-Zhen Liu, Yang Yang, Yu Zhang, Jia-Jie Hao, Hai Yang, Xiao-Min Wang, Zi-Qiang Zhang, Qi-Min Zhan, Ming-Rong Wang
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (3): 203–214.
https://doi.org/10.1042/CS20120270
Published: 17 October 2012
...Bo-Shi Wang; Yi-Zhen Liu; Yang Yang; Yu Zhang; Jia-Jie Hao; Hai Yang; Xiao-Min Wang; Zi-Qiang Zhang; Qi-Min Zhan; Ming-Rong Wang There have been multiple lines of evidence suggesting that autophagy selectively targets signalling proteins and regulates cancer cell signalling in addition to bulk...
View article titled, <span class="search-highlight">Autophagy</span> negatively regulates cancer cell proliferation via selectively targeting VPRBP
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Includes: Supplementary data
Articles

Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n −3 fatty acids: molecular mechanisms and potential clinical applications

Ramón Rodrigo, Juan C. Prieto, Rodrigo Castillo
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (1): 1–15.
https://doi.org/10.1042/CS20110663
Published: 07 September 2012
... 6 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 antioxidant apoptosis autophagy ischaemia/reperfusion necrosis oxidative stress Coronary heart disease is the most common cause of death in the Western world, and it is likely that its incidence...
View article titled, Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n −3 fatty acids: molecular mechanisms and potential clinical applications
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Articles

Ubiquitin–proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms

Susagna Padrissa-Altés, Mohamed Amine Zaouali, Ramon Bartrons, Joan Roselló-Catafau
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (2): 93–98.
https://doi.org/10.1042/CS20110093
Published: 23 March 2012
... of AMPK (AMP-activated protein kinase) activity and the consequent down-regulation of mTOR (mammalian target of rapamycin), which may finally influence autophagy and preserve the energy state of the cell. Our work is supported by the Ministerio de Sanidad y Consumo (Madrid, Spain) [project grant...
View article titled, Ubiquitin–proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms
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Articles

AMP-activated protein kinase, stress responses and cardiovascular diseases

Shaobin Wang, Ping Song, Ming-Hui Zou
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (12): 555–573.
https://doi.org/10.1042/CS20110625
Published: 05 March 2012
...)/redox balance, autophagy, cell proliferation, cell apoptosis, cellular polarity, mitochondrial function and genotoxic response, either directly or indirectly via numerous downstream pathways under physiological and pathological conditions. The potential beneficial effects of AMPK activation in disease...
View article titled, AMP-activated protein kinase, stress responses and cardiovascular diseases
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Articles

Dining in with BCL-2: new guests at the autophagy table

Marc Germain, Ruth S. Slack
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (3): 173–181.
https://doi.org/10.1042/CS20090310
Published: 26 October 2009
...Marc Germain; Ruth S. Slack BCL-2 homologues are major regulators of apoptosis and, as such, play an active role in the survival of adult neurons following injury. In recent years, these proteins have also been associated with the regulation of autophagy, a catabolic process involved...
View article titled, Dining in with BCL-2: new guests at the <span class="search-highlight">autophagy</span> table
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Articles

Autophagy in disease: a double-edged sword with therapeutic potential

Wim Martinet, Patrizia Agostinis, Barbara Vanhoecke, Michael Dewaele, Guido R. Y. de Meyer
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (9): 697–712.
https://doi.org/10.1042/CS20080508
Published: 02 April 2009
...Wim Martinet; Patrizia Agostinis; Barbara Vanhoecke; Michael Dewaele; Guido R. Y. de Meyer Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy occurs constitutively...
View article titled, <span class="search-highlight">Autophagy</span> in disease: a double-edged sword with therapeutic potential
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