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Keywords: BCR-ABL
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Clin Sci (Lond) (2006) 111 (4): 233–249.
Published: 13 September 2006
..., is of major importance in the development of many haematological malignancies. An understanding of the mechanisms by which BCR - ABL contributes to the pathogenesis of chronic myeloid leukaemia led to the development of imatinib, the first of several tyrosine kinase inhibitors to enter clinical trials...