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Keywords: CGS 34225
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Articles
Angelo J. TRAPANI, Michael E. BEIL, Charles W. BRUSEO, Cynthia A. FINK, Denton HOYER, Paula SAVAGE, Arco Y. JENG
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 102S–106S.
Published: 01 September 2002
.... The purpose of the present study was to characterize the inhibitory effects of CGS 34225, an orally active prodrug of CGS 34226, on ECE-1 and NEP in vivo . The effects on ECE-1 and NEP were assessed by determining the inhibition of big endothelin-1 (big ET-1)-induced increases in mean arterial pressure (MAP...
