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Gayathri K. Balasuriya, Mitra Mohsenipour, Kurt Brassington, Aleksandar Dobric, Simone N. De Luca, Kevin Mou, Huei Jiunn Seow, Chalystha Yie Qin Lee, Madushani Herath, Stanley M.H. Chan, Ross Vlahos, Elisa L. Hill-Yardin
Clin Sci (Lond) (2020) 134 (22): 2943–2957.
Published: 16 November 2020
... obstructive pulmonary disease (COPD) for which a major cause is cigarette smoking (CS). The underlying mechanisms and precise effects of CS on gut contractility, however, are not fully characterised. Therefore, the aim of the present study was to investigate whether CS impacts GI function and structure...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (13): 1631–1635.
Published: 01 July 2020
...Stephan F. van Eeden; Kentaro Akata Lung macrophages (LMs) are key immune effector cells that protect the lung from inhaled particulate matter, noxious gases and pathogens. In Chronic Obstructive Pulmonary Disease (COPD), there is an abundance of macrophages in airspaces and lung tissues suggesting...
Brianna Atto, Mathew Suji Eapen, Pawan Sharma, Urs Frey, Alaina J. Ammit, James Markos, Collin Chia, Josie Larby, Greg Haug, Heinrich C. Weber, George Mabeza, Stephen Tristram, Stephen Myers, Dominic P. Geraghty, Katie L. Flanagan, Philip M. Hansbro, Sukhwinder Singh Sohal
Clin Sci (Lond) (2019) 133 (14): 1663–1703.
Published: 25 July 2019
... diseases are among the leading causes of mortality worldwide, with the major contributor, chronic obstructive pulmonary disease (COPD) accounting for approximately 3 million deaths annually. Frequent acute exacerbations (AEs) of COPD (AECOPD) drive clinical and functional decline in COPD and are associated...
Clin Sci (Lond) (2019) 133 (13): 1523–1536.
Published: 15 July 2019
...Xiao Sun; Xiuli Feng; Dandan Zheng; Ang Li; Chunyan Li; Siying Li; Zhongxi Zhao Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). CS heightens inflammation, oxidative stress and apoptosis. Ergosterol is the main bioactive ingredient in Cordyceps sinensis ( C...
Clin Sci (Lond) (2018) 132 (9): 943–958.
Published: 14 May 2018
...Dan Wang; Sirong He; Bicui Liu; Chuntao Liu Activation of alveolar macrophages (AMs) and the release of cytokines play critical roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the mechanisms of AM activation. miRNAs have recently emerged...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (24): 2847–2863.
Published: 04 December 2017
...Yan Li; Michael H. Cho; Xiaobo Zhou COPD (chronic obstructive pulmonary disease) is characterized by irreversible lung airflow obstruction. Cigarette smoke is the major risk factor for COPD development. However, only a minority number of smokers develop COPD, and there are substantial variations...
Clin Sci (Lond) (2017) 131 (11): 1147–1159.
Published: 22 May 2017
...Yujie Wang; Man Jia; Xiaoyi Yan; Limin Cao; Peter J. Barnes; Ian M. Adcock; Mao Huang; Xin Yao Airway remodelling is an important component of chronic obstructive pulmonary disease (COPD). Neutrophil gelatinase-associated lipocalin (NGAL) from neutrophils may drive COPD epithelial–mesenchymal...
Clin Sci (Lond) (1995) 88 (4): 453–461.
Published: 01 April 1995
... control of breathing COPD motor control tracking task Clinical Science (1995) 88, 453-461 (Printed in Great Britain) 453 Is voluntary control of breathing impaired in patients with chronic obstructive pulmonary disease? Eytan COHEN, Kevin MURPHY, Lewis ADAMS, Abraham GUZ and Gila BENCHETRIT...