... focuses largely on the developmental programming of cardiovascular function and begins with a brief discussion on the emergence of the ‘Barker hypothesis’, and its subsequent evolution into the more-encompassing DOHaD framework. We then discuss some fundamental pathophysiological processes by which...

... and cardiovascular and renal diseases [ 28 ], it has been suggested that ACE inhibitors and Ang II-receptor blockers (ARBs) may increase the risk of COVID-19 infection by up-regulating ACE2 [ 29 , 30 ]. On the other hand, it has been proposed that inhibitors of the RAS, particularly ARBs, may actually have...

... play an important role in human health and disease, including cardiovascular and autoimmune diseases. Changes in the composition of gut microbiota (dysbiosis) are linked to chronic inflammation, thrombosis, atherogenesis, chronic heart, and kidney disease, as well as to autoimmune diseases like...

...Giulia Ferrannini; Lars Rydén Cardiovascular (CV) disease (CVD) is the main cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Despite optimal glycaemic control, standard antihyperglycaemic therapy failed to impact CV events in intervention trials; therefore, the U.S...

... markers of acute kidney injury, as it is rapidly released after tubular damage. However, a growing body of evidence highlights an important role for NGAL beyond that of a biomarker of renal dysfunction. Indeed, numerous studies have demonstrated a role for NGAL in both cardiovascular and renal diseases...

... are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca 2+ mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non...

.... In the present review, we consider recent results from pharmacogenomics and the role of sex in studies that are relevant to cardiovascular therapy. We focus on genome-wide analyses, because they have obvious advantages compared with targeted single-candidate gene studies. For instance, genome-wide approaches do...

... mechanism against AT1R-mediated actions. Thus, this review will focus on providing insights into the biological role of the AT2R, in particular its actions within the renal and cardiovascular system. The AT2R belongs to the rhodopsin subclass of GPCRs and comprises 363 amino acids [ 21 , 23 , 24...

... Sarah Lindsey (email [email protected] ). 16 2 2016 17 2 2016 2 3 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cancer cardiovascular GPR30 menopause metabolism reproduction Oestrogen...

...Cheng Qian; Regien G. Schoemaker; Wiek H. van Gilst; Anton J. M. Roks Intervention in the RAAS (renin–angiotensin–aldosterone system) is one of the leading pharmacotherapeutic strategies, among others, used for the treatment of cardiovascular disease to improve the prognosis after myocardial...

...: Dr D. O'Mahony, Department of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Republic of Ireland. 19 3 1999 29 6 1999 7 9 1999 The Biochemical Society and the Medical Research Society © 2000 2000 aging cardiovascular sympathetic vagus function...

... DE Amsterdam, The Netherlands. 12 2 1999 15 4 1999 23 5 1999 The Biochemical Society and the Medical Research Society © 1999 1999 cardiovascular fingers posture thermodilution tilt-table test 291Clinical Science (1999) 97, 291 301 (Printed in Great Britain...

...Gerard A. Rongen; John S. Floras; Jacques W. M. Lenders; Theo Thien; Paul Smits 1. This review focuses on the extracellular actions of ATP and adenosine, and in particular their role in cardiovascular regulation. 2. ATP serves as a co-transmitter within the sympathetic nervous system, and is also...

... secretion rates were derived using isotope dilution methodology. Heart rate and blood pressure spectral analysis measurements were also made. The relation of sympatho-adrenal activity to thermogenic and cardiovascular events was studied. Sympathetic nervous and thermogenic responses were measured for 120...