... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Cerebrospinal fluid CNS clearance Glymphatic Perivascular space Small vessel disease There are 46.8 million people worldwide suffering from dementia, and while there are several distinct...

... in Th17-polarized cells. Moreover, in the cerebrospinal fluid (CSF) of 107 RR-MS patients, IL-9 inversely correlated with indexes of inflammatory activity, neurodegeneration and disability progression of MS. High levels of IL-9 were associated with the absence of IL-17 in the CSF of RR-MS patients. Our...

... in noradrenergic neurons and chromaffin cells. Although dopamine β-hydroxylase enzymic activity is measurable in cerebrospinal fluid, such activity is unstable, and its relationship to central noradrenergic neuronal activity in humans is not clearly established. To explore the significance of cerebrospinal fluid...

...C. Tsigos; L. T. Diemel; A. White; D. R. Tomlinson; R. J. Young 1. Lumbar spinal substance P and calcitonin-gene-related peptide derive from spillage out of the dorsal horns associated with activity of small primary sensory afferents (C- and Aδ-fibres). Cerebrospinal fluid and sural nerve levels...

...Marcello Fanciullacci; Massimo Alessandri; Maria Nicolodi; Sergio Michelacci; Federigo Sicuteri 1. Converting enzyme and neutral endopeptidase activities were both measured every 3 h by a fluorimetric method in plasma and cerebrospinal fluid of patients diagnosed as migraineurs with aura after...

... or pressor response to digoxin in guinea-pigs. 3. Infusion of high-sodium cerebrospinal fluid, but not normal-sodium cerebrospinal fluid, into the lateral brain ventricle of rats caused marked increases in blood pressure, urine volume and urinary sodium excretion. 4. Digibind did not significantly affect...

... cerebrospinal fluid depressor effect kinin antagonist kinin receptor spontaneously hypertensive rats Clinical Science (I 992) 82, 5 13-5 I 9 (Printed in Great Britain) 513 Central bradykininergic system in normotensive and hypertensive rats Azucena L. ALVAREZ, Alejandro DELORENZI, Daniel SANTAJULIANA...

...-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels...

... of cerebrospinal fluid, cortex, cerebellum and spinal cord were then extracted and analysed for S -adenosyl- l -methionine and S -adenosyl- l -homocysteine. Regression analyses were carried out on values obtained in cerebrospinal fluid and in neural tissues. 2. Highly significant correlations were obtained between...

...Minoru Kawamura; Yuhei Kawano; Kaoru Yoshida; Masahito Imanishi; Satoshi Akabane; Yohkazu Matsushima; Morio Kuramochi; Kazuaki Shimamoto; Keiichi Ito; Teruo Omae 1. Angiotensin (ANG) levels were measured in the cerebrospinal fluid of 15 patients with essential hypertension on a high sodium diet...

... of high Na + artificial cerebrospinal fluid (CSF) on blood pressure, urinary Na + excretion and plasma ANP levels in conscious Wistar rats. 2. Infusion of high Na + (0.6 mol/1) CSF into the lateral ventricle at a rate of 1 μl/min for 60 min significantly increased mean blood pressure and urinary Na...

...Jimmy D. Bell; Judith C. C. Brown; Peter J. Sadler; Andrew F. MacLeod; Peter H. Sönksen; Robin D. Hughes; Roger Williams 1. One- and two-dimensional (correlated shift spectroscopy) high resolution proton n.m.r. spectra of human cerebrospinal fluid (CSF) are reported. The merits of water suppression...

...A. Gorchein; R. Webber 1. ô-Aminolaevulinic acid (ALA) was determined by g.l.c. with electron-capture detection. Normal plasma level was 92 nmol/l ( sd = 39, n = 89, range 24–270 nmol/l). 2. ALA was undetectable in 35 of 53 samples of normal cerebrospinal fluid (limit of assay 2 nmol/l). The mean...

...J. E. Maddison; D. Yau; P. Stewart; G. C. Farrell 1. Cerebrospinal fluid (CSF) γ-aminobutyric acid (GABA) levels were measured in a dog model of spontaneous chronic portosystemic encephalopathy. 2. Dogs with congenital portacaval shunts (intra- or extra-hepatic) develop neurological features...

... that cerebrospinal fluid from patients with infantile and juvenile neuronal ceroid-lipofuscinosis were less protective against superoxide radical-induced hydroxyl radical formation compared with controls [3]. 2. The content of superoxide dismutase isoenzymes in cerebrospinal fluid and in plasma from patients...

... + −pump activity was estimated in the plantar and dorsal branches of the lateral saphenous veins by using the 86 Rb-uptake method. 2. Infusion of the cerebral ventricles with the artificial cerebrospinal fluid (CSF) containing normal Na + (0.15 mol/l) for over 120 min resulted in significant increases...

...Yoshiaki Masuyama; Yuji Ueno; Mikio Arita; Hidetoshi Suruda; Osamu Mohara 1. The effects of circulating angiotensin II on cerebrospinal fluid and plasma noradrenaline during frusemide administration and acute renal artery constriction were studied in dogs. 2. The administration of frusemide...

...C. R. Lake; R. J. Polinsky; H.-G. Gullner; M. H. Ebert; M. G. Ziegler; F. C. Bartter; I. J. Kopin 1. Eleven patients with essential hypertension and nine healthy normotensive volunteer subjects, all without a neurological disorder, had blood drawn and cerebrospinal fluid sampled for analysis...

...J. S. Hutchinson; J. Csicsmann; P. I. Korner; C. I. Johnston 1. Immunoreactive angiotensin II was measured in cerebrospinal fluid of four normal dogs. 2. The migration of this immunoreactive angiotensin II on polyacrylamide-slab gel electrophoresis was identical with the migration...

... anticonvulsant drugs cerebrospinal fluid choroid plexus methyltetrahydrofolic acid Clinical Science and Molecular Medicine (1977) 53, 75-80. Effect of anticonvulsants on the uptake of Smethyltetrahydrofolic acid by the choroid plexus in rabbits H. TAGUCHI,* Z. ABDUL-CADER, J. PERRY, E. H. REYNOLDS AND I...

...J. S. Hutchinson; P. Schelling; J. Möhring; D. Ganten 1. Artificial cerebrospinal fluid was perfused through the cerebral ventricles of conscious rats. A basal secretion rate of 16 ± 3 × 10 —15 mol of immunoreactive angiotensin 11/min was calculated for intact rats. 2. Most of the immunoreactive...

...). The concentration of the acids in the cerebrospinal fluid (CSF) perfusate have been compared with changes in integrated low-frequency activity in the EEG. 2. The C-5 acids investigated were those accumulating in inborn errors of metabolism, i.e. isovaleric acid, β-methylcrotonic acid, tiglic acid and α-keto- and α...

...N. N. Stanley; B. G. Salisbury; L. C. McHenry, Jr; N. S. Cherniack 1. The acid-base state of arterial blood and cerebrospinal fluid, and the ventilatory response to CO 2 , were measured in twelve patients with liver disease. The CO 2 response was also measured in eight goats before and after...

...D. Ganten; J. S. Hutchinson; P. Schelling 1. Angiotensin is produced by the intrinsic iso-renin-angiotensin system. 2. Angiotensin is secreted into the cerebrospinal fluid of nephrectomized rats. 3. Angiotensin in cerebrospinal fluid elevates systemic blood pressure. 4. Rats with hereditary...

... Society 1974 cerebrospinal fluid methyltetrahydrofolic acid Clinical Science and Molecular Medicine (1974) 46, 369-373. TRANSPORT O F 5-METHYLTETRAHYDROFOLIC ACID INTO THE CEREBROSPINAL F L U I D IN M A N I. CHANARIN, JANET PERRY AND E. H. REYNOLDS Northwick Park Hospital and Clinical Research...