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Keywords: Cisplatin
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Clin Sci (Lond) (2021) 135 (10): 1273–1288.
Published: 26 May 2021
...Hao Zhao; Yachun Han; Na Jiang; Chenrui Li; Ming Yang; Ying Xiao; Ling Wei; Xiaofen Xiong; Jinfei Yang; Chengyuan Tang; Li Xiao; Fuyou Liu; Yu Liu; Lin Sun Cisplatin (Cis) can cause chronic kidney disease (CKD) and promote renal fibrosis, but the underlying mechanism is not fully understood...
Clin Sci (Lond) (2018) 132 (7): 825–838.
Published: 16 April 2018
... a novel, orally active, small-molecule HIF PHD inhibitor for the treatment of anemia in patients with chronic kidney disease (CKD). The current study aimed to evaluate the effect of FG-4592 (Roxadustat) on cis -diamminedichloroplatinum (cisplatin)-induced kidney injury. In mice, pretreatment with FG...
Clin Sci (Lond) (2018) 132 (3): 339–359.
Published: 02 February 2018
.... Nonetheless, its specific role in drug-induced nephrotoxicity is poorly understood. Cisplatin (dichlorodiamino platinum) belongs to an inorganic platinum – fundamental chemotherapeutic drug utilized in the therapy of various solid malignant tumors. However, the use of cisplatin is extremely limited by obvious...
Includes: Supplementary data
Clin Sci (Lond) (2004) 106 (5): 475–484.
Published: 01 May 2004
...N. I. WEIJL; T. J. ELSENDOORN; R. M. W. MOISON; E. G. W. M. LENTJES; R. BRAND; H. M. BERGER; S. OSANTO Non-protein bound iron (NPBI) is able to catalyse oxidative reactions, causing damage to vital structures. Adverse effects induced by cisplatin seem, in part, to be mediated by free radicals. In...
Clin Sci (Lond) (1987) 73 (4): 377–381.
Published: 01 October 1987
...Christopher J. Lote; Ernest S. Harpur; Andrew Thewles; Donna J. Phipps 1. Cisplatin [6 mg/kg body weight, in 0.9% (w/v) NaCl] was injected intraperitoneally as a single dose to two groups of rats (Fischer 344 strain). Two further groups of rats, injected intraperitoneally with an equivalent volume...