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Keywords: Compound 21
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Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
...Raquel González-Blázquez; Martín Alcalá; María S. Fernández-Alfonso; Ulrike Muscha Steckelings; M. Paz Lorenzo; Marta Viana; William A. Boisvert; Thomas Unger; Marta Gil-Ortega; Beatriz Somoza Compound 21 (C21), a selective agonist of angiotensin II type 2 receptor (AT 2 R), induces vasodilation...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (15): 1307–1326.
Published: 29 June 2016
... mechanism against AT1R-mediated actions. Thus, this review will focus on providing insights into the biological role of the AT2R, in particular its actions within the renal and cardiovascular system. AT2 receptor AT2R agonism cardiovascular compound 21 kidney To date, it still remains unclear...
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Clin Sci (Lond) (2015) 129 (1): 81–92.
Published: 15 April 2015
... pressure responses to stimulation of central AT 2 Rs by the selective agonist Compound 21 in conscious spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKY rats). We also assessed the impact on noradrenaline [norepinephrine (NE)] plasma levels, autonomic function, spontaneous...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (9): 567–578.
Published: 11 February 2015
... II and the AT 1 receptor antagonist, losartan, induces apoptosis but does not affect the rate of cell death. We demonstrate for the first time that the high-affinity, non-peptide AT 2 receptor agonist, Compound 21 (C21), penetrates the cell membrane of quiescent SK-UT-1 cells, activates intracellular...
Articles
Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
... of binding affinities of all the major angiotensin peptides. Additionally, we tested the novel AT 2 R agonist Compound 21, as well as the Mas R ( Mas receptor) agonist and antagonist AVE0991 and A-779 respectively, for their ability to bind to AT 1 R or AT 2 R. Candesartan, CGP42214 and PD123319 were used...