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Keywords: Compound 21
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Clin Sci (Lond) (2018) 132 (6): 627–640.
Published: 20 March 2018
... in APA-adjacent tissue. The effect of Compound 21 (C21), an AT2R agonist, on CYP11B1 (cortisol synthase) and CYP11B2 (aldosterone synthase) gene expression in NCI-H295R and HAC15 cell lines, and in APA and APA-adjacent tissue, was also assessed using the AT1R antagonist irbesartan to ascertain the...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (15): 1307–1326.
Published: 29 June 2016
... AT2 receptor AT2R agonism cardiovascular compound 21 kidney The AT2R has been increasingly suggested to play a critical role in regulating cellular differentiation and organ development due to its high abundance in fetal mesenchymal tissues [ 28 , 29 ]. Although AT2R expression has...
Clin Sci (Lond) (2015) 129 (1): 81–92.
Published: 15 April 2015
... pressure responses to stimulation of central AT 2 Rs by the selective agonist Compound 21 in conscious spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKY rats). We also assessed the impact on noradrenaline [norepinephrine (NE)] plasma levels, autonomic function, spontaneous...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (9): 567–578.
Published: 11 February 2015
... II and the AT 1 receptor antagonist, losartan, induces apoptosis but does not affect the rate of cell death. We demonstrate for the first time that the high-affinity, non-peptide AT 2 receptor agonist, Compound 21 (C21), penetrates the cell membrane of quiescent SK-UT-1 cells, activates intracellular...
Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
... binding affinities of all the major angiotensin peptides. Additionally, we tested the novel AT 2 R agonist Compound 21, as well as the Mas R ( Mas receptor) agonist and antagonist AVE0991 and A-779 respectively, for their ability to bind to AT 1 R or AT 2 R. Candesartan, CGP42214 and PD123319 were used as...