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1-27 of 27
Keywords: Covid-19
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Articles
Anna Liu, Natalia Ruetalo, Janet P. Raja Xavier, Aditya Kumar Lankapalli, Jakob Admard, Miguel Camarena-Sainz, Sara Y. Brucker, Yogesh Singh, Michael Schindler, Madhuri S. Salker
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (04): 287–307.
Published: 19 February 2025
... Attribution License 4.0 (CC BY) . COVID-19 endometrium pregnancy SARS-CoV-2 spheroids During pregnancy, the female body is subject to profound physiological changes. The immune system is altered to balance immunotolerance of the semiallogenic conceptus whilst providing protection against...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (7): 489.
Published: 04 April 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 CD147 COVID-19 Microvascular disease...
Articles
Antiviral activities of hemp cannabinoids
Open Access
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (8): 633–643.
Published: 21 April 2023
.... Mechanisms of action include inhibition of viral cell entry, inhibition of viral proteases, and stimulation of cellular innate immune responses. The anti-inflammatory properties of cannabinoids are also under investigation for mitigating the cytokine storm of COVID-19 and controlling chronic inflammation...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1571–1590.
Published: 11 November 2022
...Jaroslav Pelisek; Benedikt Reutersberg; Urs F Greber; Alexander Zimmermann Although COVID-19 is primarily a respiratory disease, it may affect also the cardiovascular system. COVID-19 patients with cardiovascular disorder (CVD) develop a more severe disease course with a significantly higher...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1439–1447.
Published: 21 October 2022
.... This approach, identifying calpeptin, through large-scale screening studies as a candidate drug to treat COVID-19, however, has not considered the longer term likely benefits of calpain inhibition, post-COVID-19. This perspective will reflect on the capacity of calpeptin for treating long COVID by inhibiting...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1047–1052.
Published: 06 July 2022
...Erin B. Taylor Dysregulation of neutrophil extracellular trap (NET) formation has been shown to mediate disease pathology in multiple viral infections, including SARS-CoV-2. At the beginning of COVID-19 pandemic, Thierry and Roch wrote a perspective on the mechanisms by which severe SARS-CoV-2...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 431–434.
Published: 29 March 2022
...John D. Imig The SARS-CoV-2 virus that results in COVID-19 has been found to damage multiple organs beyond the lung. Interestingly, the SARS-CoV-2 spike (S) protein can be found circulating in the blood of COVID-19 patients. Experimental findings are demonstrating that the circulating S protein can...
Articles
In Collection
Coronavirus
Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
Published: 15 December 2021
... cellular stress. We tested this hypothesis in pericytes (PCs), which are reportedly reduced in the heart of patients with severe coronavirus disease-2019 (COVID-19). Here we newly show that the in vitro exposure of primary human cardiac PCs to the SARS-CoV-2 wildtype strain or the α and δ variants caused...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
...Nayara Azinheira Nobrega Cruz; Danielle Stoll; Dulce Elena Casarini; Mariane Bertagnolli In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1009–1014.
Published: 21 April 2021
..., and their safety was addressed in COVID-19 patients. Pedrosa et al. ( Clin. Sci. ( Lond. ) (2021), 135 , 465–481) showed in rats that captopril and candesartan up-regulated ACE2 expression and the protective RAS pathway in lung tissue. In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation...
Articles
ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders
Available to PurchaseIn Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
, Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 ACE2 COVID-19 diabetes energy homeostasis renin-angiotensin system SARS-CoV-2 Energy metabolism is typically defined as a biological process of energy storage, release, transfer, and utilization during the nutrients (mainly...
Articles
ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease
Open Access
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
...)-coronavirus (CoV) and SARS-Cov-2, which cause SARS and coronavirus disease-19 (COVID-19) respectively. ACE-2 is thus a double-edged sword: it promotes cardiovascular health while also facilitating the devastations caused by coronaviruses. COVID-19 is associated with cardiovascular disease as a risk factor...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
... and a receptor for SARS-CoV-2 as well as the implications for Coronavirus disease 19 and its associated cardiovascular and renal complications. Correspondence: Mohan K. Raizada ( [email protected] ) or Rajesh Mohandas ( [email protected] ) ACE2 COVID-19 Heart Failure Hypertension...
Articles
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3229–3232.
Published: 11 December 2020
... – from cardiovascular regulation to coronavirus disease 2019 (COVID-19). The multiple and mainly curative functions of ACE2 render it a popular drug target. However, while very efficient inhibitors have been described [ 26 ], it is activators that are desirable. Li et al. discuss the approaches pursued...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
... is hijacked by SARS-CoV-2 as a cellular receptor to gain entry to alveolar epithelial cells, causing COVID-19, a severe respiratory disease in humans. COVID-19 is frequently life-threatening especially in elderly or people with other medical conditions. As an unprecedented number of COVID-19 patients have...
Articles
ACE2 in the renin–angiotensin system
Available to PurchaseThiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions to allow a rapid and coordinated...
Articles
Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists
Open AccessIn Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
, Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
...U. Muscha Steckelings; Colin Sumners The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for the global corona virus disease 2019 (COVID-19) pandemic enters host cells via a mechanism that includes binding to angiotensin converting enzyme (ACE) 2 (ACE2). Membrane...
Articles
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV
Open AccessIn Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
, Protein structure and function
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2851–2871.
Published: 04 November 2020
... (SARS)-coronavirus (CoV)-2 responsible for the 2020, coronavirus infectious disease 2019 (COVID-19) pandemic. Understanding the interaction between SARS-CoV-2 and ACE2 is crucial for the design of therapies to combat this disease. This review provides a comparative analysis of methodologies and findings...
Articles
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... describe the emerging kidney manifestations of COVID-19, namely the frequent development of acute kidney injury. The possibility that binding of SARS-CoV-2 to kidney ACE2 plays a role in the kidney manifestations is also briefly discussed. In this review, we will focus on kidney ACE2; its localization...
Articles
Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
... and serendipitously as a viral receptor, mediating the cellular entry of the coronaviruses causing severe acute respiratory syndrome (SARS) and, very recently, COVID-19. Catalytically, ACE2 functions as a monocarboxypeptidase principally converting the vasoconstrictor angiotensin II to the vasodilatory peptide Ang-(1...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2315–2317.
Published: 09 September 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Coronavirus COVID-19 signaling pathway SARS-CoV-2 The authors...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2235–2241.
Published: 01 September 2020
... antibody. Trapping SARS-CoV-2 Mpro cysteine protease using cross-class serpin cysteine protease inhibition activity is a novel idea with significant therapeutic potential. APTT activated partial thromboplastin time CoV coronavirus Covid-19 coronavirus disease Mpro main protease...
Articles
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission
Open AccessIn Collection
Coronavirus
Daniella S. Battagello, Guilherme Dragunas, Marianne O. Klein, Ana L.P. Ayub, Fernando J. Velloso, Ricardo G. Correa
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2137–2160.
Published: 21 August 2020
...Daniella S. Battagello; Guilherme Dragunas; Marianne O. Klein; Ana L.P. Ayub; Fernando J. Velloso; Ricardo G. Correa The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses – the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – discovered...
Articles
In Collection
Coronavirus
Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
...Thiago Gomes Heck; Mirna Stela Ludwig; Matias Nunes Frizzo; Alberto Antonio Rasia-Filho; Paulo Ivo Homem de Bittencourt, Jr The major risk factors to fatal outcome in COVID-19 patients, i.e., elderliness and pre-existing metabolic and cardiovascular diseases (CVD), share in common...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1301–1304.
Published: 16 June 2020
...Jameel M. Inal The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes uptake, through attachment...
Articles
In Collection
Coronavirus
Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
... mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin–angiotensin system (RAS...
Articles
ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19
Available to PurchaseIn Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 747–750.
Published: 07 April 2020
... and cardiovascular and renal diseases [ 28 ], it has been suggested that ACE inhibitors and Ang II-receptor blockers (ARBs) may increase the risk of COVID-19 infection by up-regulating ACE2 [ 29 , 30 ]. On the other hand, it has been proposed that inhibitors of the RAS, particularly ARBs, may actually have...
