..., but not limited to, critical illness myopathy and sepsis-induced myopathy. Pre-clinical models of critical illness can provide insights into the mechanisms underlying muscle wasting and weakness. Cell culture systems can provide mechanistic interrogation, by isolating effects to skeletal muscle directly. Small...

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Critical Illness Fasting Hypercortisolemia Ketogenesis Sepsis Tight...

...Arno Téblick; Jan Gunst; Lies Langouche; Greet Van den Berghe Sepsis is defined as any life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains an important cause of critical illness and has considerable short- and long-term morbidity and mortality...

... represents a surrogate for hepatocyte death in liver injury. In critically ill patients, miR-192-5p levels were elevated selectively in patients with liver injury and closely correlated with the presence of hepatic injury. In contrast with up-regulated miR-192-5p in the serum, we detected a down-regulation...

...)], with no differences between the legs. In conclusion, NMES represents an effective and feasible interventional strategy to prevent skeletal muscle atrophy in critically ill comatose patients. critical illness disuse atrophy intensive care unit (ICU) muscle wasting neuromuscular electrical stimulation (NMES...

...Maria Klaude; Maiko Mori; Inga Tjäder; Thomas Gustafsson; Jan Wernerman; Olav Rooyackers Muscle wasting negatively affects morbidity and mortality in critically ill patients. This progressive wasting is accompanied by, in general, a normal muscle PS (protein synthesis) rate. In the present study...

... 2003 critical illness glutamine growth hormone hypoalbuminaemia liver protein synthesis Clinical Science (2003) 105, 691 698 (Printed in Great Britain) 691 Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone Michael J. O LEARY...

... 5 2001 The Biochemical Society and the Medical Research Society © 2001 2001 animal disease models caecal ligation and puncture critical illness glutamine/metabolism liver muscle protein synthesis rats sepsis surgery 295Clinical Science (2001) 101, 295 304 (Printed in Great...

... after zymosan indicated that the rats were still not fully recovered on this day. 4. We conclude that injection of a single dose of zymosan in rats leads to metabolic derangements both during the acute phase of critical illness and during the prolonged recovery phase. The model seems suited...

... the most significant effect on whole body protein turnover. 10 2 1993 11 3 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 critical illness energy expenditure L-[L- 13 C]leucine protein kinetics Clinical Science (1993) 81, 655-661 (Printed in Great...