... to this work. 19 02 2018 13 03 2018 14 03 2018 14 03 2018 Crohn’s disease (CD) and ulcerative colitis (UC) are the major forms of chronic inflammatory bowel diseases (IBD) in humans. Although the etiology of both IBD is unknown, several environmental factors acting...

...Francesca Zorzi; Emma Calabrese; Giovanni Monteleone In Crohn's disease, one of the two major forms of inflammatory bowel diseases in human beings, persistent and chronic inflammation promotes fibrotic processes thereby facilitating formation of strictures, the most common indication for surgical...

... and function, in IBD. A significant increase in IL-34 mRNA and protein expression was seen in inflamed mucosa of patients with CD (Crohn's disease) and patients with UC (ulcerative colitis) compared with the uninvolved areas of the same patients and normal controls. IL-34 was up-regulated in LPMCs (lamina...

... (Crohn's disease) that may mandate surgical resection. Accurate biomarkers that reflect the relative contribution of fibrosis to an individual stricture are an unmet need in managing patients with CD. The miRNA-29 ( miR-29 ) family has been implicated in cardiac, hepatic and pulmonary fibrosis...

...-damaging immune response in IBDs. Correspondence: Dr Giovanni Monteleone (email [email protected] ). 11 1 2010 16 2 2010 25 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 Crohn's disease cytokine inflammatory bowel disease (IBD...

... investigated the cellular and molecular mechanisms of interactions between intestinal mucosal cells and the resident luminal bacteria in healthy individuals and patients with ulcerative colitis and Crohn's disease. Mechanisms by which the intestinal mucosa is able to avoid pro-inflammatory responses...

...Jack Satsangi; Miles Parkes; Derek P. Jewell; John I. Bell 1. The aetiology of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided little insight into disease pathogenesis. 2...

...Stephen P. Pereira; Theresa B. Cassell; Jeffrey L Engelman; Gordon E. Sladen; Gerard M. Murphy; R. Hermon Dowling 1. Increased concentrations of plasma polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease. However, it is not known whether there are corresponding...

... outcome. 3. IgM, but not IgG, lipocortin-I antibody levels were elevated in patients with ulcerative colitis and Crohn's disease compared with healthy control subjects. In patients with Crohn's disease not taking corticosteroids, IgM lipocortin-I antibody levels were directly related to disease activity...

...F. E. Murray; M. McNicholas; W. Stack; D. P. O'Donoghue 1. The incidence of gallstones in patients with Crohn's disease is increased compared with that in healthy control subjects. This is in part due to reduced terminal ileal bile salt absorption and consequent increased cholesterol saturation...

.... 2. Rectal biopsies taken at colonoscopy from patients with ulcerative colitis (n = 9), patients with Crohn's disease ( n = 6) and control subjects ( n = 16) were cultured for 24 h in the presence of N -[ 3 H]acetyl-glucosamine and [ 35 S]sulphate. Mucin was then extracted and purified, and the ratio...

...Jamal El Yamani; Charlotte Mizon; Calliope Capon; Jean-Frederic Colombel; Bernard Fournet; Antoine Cortot; Jacques Mizon 1. α 1 -Proteinase inhibitor (α 1 -antitrypsin) is excreted in a deglycosylated form ( M r 38000) in the faeces of healthy subjects and in patients with quiescent Crohn's disease...

... colitis [median 74.5 (range 17.7–450.8) pg/mg] than in patients with active Crohn's disease [10.4 (4–46.9) pg/mg; P <0.002] or in normal control subjects [10.4(4–16.6) pg/mg; P <0.002]. 3. Circulating neutrophil-activating peptide-1/interleukin-8 was generally undetectable but there were higher...

... lack of neutral sugars. 4. In contrast, the M r -51000 form of α 1 -proteinase inhibitor is glycosylated and thus could be differentiated by virtue of its reactivity with concanavalin A. The analysis of 25 faecal extracts from patients with Crohn's disease allowed us to confirm that the presence...

... and in Crohn's disease, but not in the irritable bowel syndrome, coeliac disease in remission or ulcerative colitis. Excretion of lactose, but not raffinose, was increased in patients with mucosal lactase deficiency, whereas excretion of l-arabinose was reduced in all disease groups except ulcerative colitis. 4...

...C. C. Ainley; J. Cason; L. K. Carlsson; B. M. Slavin; R. P. H. Thompson 1. The zinc contents of plasma, erythrocytes, polymorphonuclear leucocytes and mononuclear leucocytes from 18 normal control subjects, 31 patients with Crohn's disease and 15 patients with ulcerative colitis were measured. 2...

... with coeliac disease and 11 patients with Crohn's disease. Total mucosal permeation was corrected for surface area measured morphometrically to provide an index of mucosal permeability. 2. In untreated coeliac disease, permeation of mannitol was reduced by 35% ( P = 0.006) and that of raffinose was increased...

... in neutrophils could not account for the differences observed. 28 5 1987 19 6 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 bacterial glycosidases Crohn's disease glycoconjugate glycoprotein mucin mucus sialic acid sialidases ulcerative colitis...

...Sergio Pacheco; Keith Hillier; Colin Smith 1. Colonic mucosa from 19 patients with ulcerative colitis, eight with Crohn's disease and 14 controls were analysed for arachidonic acid (C20:4), linoleic acid (C18:2), oleic acid (C18:1), stearic acid (C18:0) and palmitic acid (C16:0). 2. Gas–liquid...

...J. R. Clamp; G. Fraser; A. E. Read 1. Mucus samples obtained from colectomy colons from 10 patients with ulcerative colitis and four patients with Crohn's disease of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated...

...A. S. Mee; D. P. Jewell 1. The activity of a specific lysosomal marker enzyme N '-acetyl-β-d-glucosaminidase has been determined fluorimetrically in the monocytes and in the serum of patients with Crohn's disease and ulcerative colitis and compared with results obtained from healthy and disease...