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Keywords: Cyp2c70
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Articles

Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool

Open Access
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Justine Gillard, Isabelle A. Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (1): 61–64.
https://doi.org/10.1042/CS20231465
Published: 10 January 2024
... in the Cyp2c70 knock-out mice, which are considered as a promising ‘humanized’ experimental resource for studying bile acids and their role in pathological conditions. We also discuss how Cyp2c70 -deficient mice contribute to enhancing the translatability of preclinical studies in murine models to humans...
View articletitled, Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool
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Articles

Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition

Open Access
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Esther Verkade, Wenqiang Shen, Milaine V. Hovingh, Niels L. Mulder, Krisztina de Bruyn, Martijn Koehorst, Hilde D. de Vries, Vincent W. Bloks, Folkert Kuipers, Jan Freark de Boer
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1637–1650.
https://doi.org/10.1042/CS20230812
Published: 10 November 2023
...Esther Verkade; Wenqiang Shen; Milaine V. Hovingh; Niels L. Mulder; Krisztina de Bruyn; Martijn Koehorst; Hilde D. de Vries; Vincent W. Bloks; Folkert Kuipers; Jan Freark de Boer Cyp2c70 -deficient mice have a human-like bile acid (BA) composition due to their inability to convert chenodeoxycholic...
View articletitled, Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition
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Includes: Supplementary data
Articles

Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70 -deficient mice with a human-like bile acid composition

Open Access
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Wilhelm Sjöland, Annika Wahlström, Kassem Makki, Marc Schöler, Antonio Molinaro, Lisa Olsson, Thomas Uwe Greiner, Robert Caesar, Jan Freark de Boer, Folkert Kuipers, Fredrik Bäckhed, Hanns-Ulrich Marschall
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (13): 995–1011.
https://doi.org/10.1042/CS20230413
Published: 14 July 2023
...Wilhelm Sjöland; Annika Wahlström; Kassem Makki; Marc Schöler; Antonio Molinaro; Lisa Olsson; Thomas Uwe Greiner; Robert Caesar; Jan Freark de Boer; Folkert Kuipers; Fredrik Bäckhed; Hanns-Ulrich Marschall Mice with deletion of Cyp2c70 have a human-like bile acid composition, display age- and sex...
View articletitled, Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70 -deficient mice with a human-like bile acid composition
Open the PDF for Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70 -deficient mice with a human-like bile acid composition in another window
Includes: Supplementary data