... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker cell-free DNA cGAS-STING DNA damage mitochondria...

...Keitaro Ueda; Chiemi Sakai; Takafumi Ishida; Kosuke Morita; Yusuke Kobayashi; Yasunori Horikoshi; Akiko Baba; Yuma Okazaki; Masao Yoshizumi; Satoshi Tashiro; Mari Ishida Cigarette smoking is a major risk factor for atherosclerosis. We previously reported that DNA damage was accumulated...

...Sarah-Eve Lemay; Sebastien Bonnet; François Potus In this commentary, we discuss new observations stating that spliced X-box-binding protein 1 (Xbp1s)-DNA damage-inducible transcript 3 (Ddit3) promotes monocrotaline (MCT)-induced pulmonary hypertension (Jiang et al., Clinical Science (2021) 135 (21...

... which vascular aging outcomes are due to local endothelial DNA damage, which was accomplished by genetic removal of ERCC1 (excision repair cross-complementation group 1) DNA repair in mice (EC-knockout (EC-KO) mice). EC-KO showed a progressive decrease in microvascular dilation of the skin, increased...

... levels of oxidative stress and significantly lower levels of antioxidant activity leading to molecular damage, including protein nitration, lipid peroxidation and DNA damage that contribute to tissue dysfunction. Furthermore, we show that elastase is elevated, suggesting that elastin is degraded...

... diabetes, to test this hypothesis, we have investigated oxidative stress pathways and DNA damage in patients with IGR and newly diagnosed Type 2 diabetes. The study population consisted of 92 subjects with NGT (normal glucose tolerance), 78 patients with IGR and 113 patients with newly diagnosed diabetes...

... 7 2004 28 7 2004 The Biochemical Society 2004 aging DNA damage mitochondrial DNA oxidative stress reactive oxygen species repair Aging can be defined as a multifactorial phenomenon characterized by a time-dependent decline in physiological function [ 1...

... The Biochemical Society and the Medical Research Society © 2001 2001 DNA damage paraoxonase -tocopherol Type II diabetes 235Clinical Science (2001) 101, 235 241 (Printed in Great Britain) Increased DNA oxidative susceptibility without increased plasma LDL oxidizability in Type II diabetes: effects...