.... Correspondence: Professor Yoshiyuki Horio (email [email protected] ). 3 12 2010 10 3 2011 11 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 deacetylation DNA repair inflammation metabolism mitochondrion sirtuin stress resistance...

... are introduced into a cell and use their nuclease activity to cause a DSB (double-strand breakage) in the chromosome in a gene's protein-coding sequence. This stimulates innate cellular DNA repair mechanisms to fix the DSB or the cell will probably die. The most active DNA repair mechanism in mammalian cells...

... the moment MTB is exhaled by infected individuals, through an active and latent phase in the body of the new host, until the time they reach the reactivation stage, MTB is exposed to many types of DNA-damaging agents. Like all cellular organisms, MTB has efficient DNA repair systems, and these are believed...

... expression of DNA damage markers and of DNA repair genes, together with the assessment of proliferation and apoptosis indexes. The expression of the oxidative DNA damage marker 7,8-dihydro-8-oxo-2′-deoxyguanosine was increased at 3 and 7 days after arteriotomy, with immunostaining distributed in the injured...

...T. Thulin; R. W. Pero; C. Bryngelsson; F. Mitelman; Å. Nordén; B. Scherstén 1. The level of DNA repair synthesis has been compared in males diagnosed as having hypertension (diastolic blood pressure ≥ 100 mmHg), males with slightly elevated blood pressure (>95th percentile corrected for age...