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Keywords: DNMT3A
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Clin Sci (Lond) (2020) 134 (23): 3079–3091.
Published: 02 December 2020
... enhances the oncogenic activity of the AML1-ETO oncoprotein by directly inhibiting the expression of CCND1 and the DNMT3A genes. Ectopic expression of miR564 can induce retardation of G 1 /S transition, reperform differentiation, promote apoptosis, as well as inhibit the proliferation and colony formation...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (13): 1843–1857.
Published: 17 July 2020
... on normal hearts, whereas it results in accelerated heart function decline, increased hypertrophy, and exacerbated heart failure in response to stress. In contrast, restoring the expression of lncRNA CHAIR rescued the hearts from hypertrophy and failure. DNMT3A was recruited to CHAIR promoter during heart...