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Keywords: DRm217
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Regulation of Na + -K + -ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca 2+ -dependent cardiac metabolism

Xiaofei Yan, Meihe Li, Ping Lan, Meng Xun, Ying Zhang, Jinghui Shi, Ruijia Wang, Jin Zheng
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (1): 23–42.
https://doi.org/10.1042/CS20231039
Published: 05 January 2024
... mitochondrial Ca 2+ via mNCE, and then finally down-regulated cardiac cell energy metabolism. In addition, a supplement of DRm217 alleviated ISO-induced heart dysfunction, mitigated cardiac remodeling, and improved cytosolic Na + and Ca 2+ elevation and mitochondrial Ca 2+ depression in the NKA α1 +/− mouse...
View article titled, Regulation of Na + -K + -ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca 2+ -dependent cardiac metabolism
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Includes: Supplementary data