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Keywords: Diabetes
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Clin Sci (Lond) (2023) 137 (15): 1195–1208.
Published: 10 August 2023
... a protective role in cells although the underlying mechanism remains unknown. To test whether MPV17 is also protective in diabetic kidney disease, we treated Mpv17 -deficient mice with streptozotocin (STZ) and surprisingly found that they were resistant to diabetes. Mpv17 deficiency was also found to confer...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (8): 697–706.
Published: 26 April 2023
...Xiaodi Zhang; Jean L.J.M. Scheijen; Coen D.A. Stehouwer; Kristiaan Wouters; Casper G. Schalkwijk The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycation endproducts (AGEs). MGO and AGEs are increased in subjects with diabetes and are associated...
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Clin Sci (Lond) (2022) 136 (24): 1873–1875.
Published: 22 December 2022
... understanding of the role of EVs in pregnancy Correspondence: Dylan Burger ( dburger@uottawa.ca ) 22 11 2022 22 11 2022 07 12 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Diabetes Exosome Extracellular Vesicles...
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Clin Sci (Lond) (2021) 135 (14): 1669–1687.
Published: 20 July 2021
...Amarens van der Vaart; Stanley M.H. Yeung; Peter R. van Dijk; Stephan J.L. Bakker; Martin H. de Borst Diabetes is associated with a strongly elevated risk of cardiovascular disease, which is even more pronounced in patients with diabetic nephropathy. Currently available guideline-based efforts...
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Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
... is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is threating public health worldwide. The main complications of SARS-CoV-2 infected death patients include many energy metabolism-related chronic diseases, such as diabetes. The specific mechanism leading to this phenomenon...
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Clin Sci (Lond) (2021) 135 (1): 127–142.
Published: 08 January 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 Cardiometabolic Disease Diabetes Epigenetics Hypertension Renin Angiotensin System Cardiometabolic disease (CMD) refers to coexisting conditions of insulin resistance, dyslipidemia, obesity, elevated blood pressure (BP...
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Clin Sci (Lond) (2020) 134 (23): 3119–3121.
Published: 03 December 2020
... in the development of diabetes mellitus and blood glucose control. After the seminal work of Paulescu and Banting and Best in the early 1920s that led to the discovery of insulin (Murray I. Paulesco and the isolation of insulin. J. Hist. Med. Allied Sci . (1971) 26 , 150–157; Raju T.N. The Nobel Chronicles. 1923...
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Clin Sci (Lond) (2020) 134 (23): 3107–3118.
Published: 02 December 2020
... and sulfonylurea gliclazide on plasma electrolytes, urinary electrolyte excretion, and acid–base balance in people with Type 2 diabetes (T2D). We assessed the effects of dapagliflozin and gliclazide treatment on plasma electrolytes and bicarbonate, 24-hour urinary pH and excretions of electrolytes, ammonium...
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Clin Sci (Lond) (2020) 134 (16): 2117–2135.
Published: 21 August 2020
...Frédéric Clarembeau; Georgia Bale; Nicolas Lanthier End-stage chronic liver diseases are often associated with insulin resistance (IR) and diabetes mellitus (DM). Indeed, to quantify insulin sensitivity the euglycemic clamp technique was utilized, allowing the following to be stated: in small...
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Clin Sci (Lond) (2020) 134 (12): 1399–1401.
Published: 18 June 2020
...Man K.S. Lee; Gopalkrishna Sreejit; Prabhakara R. Nagareddy; Andrew J. Murphy In volume 133 issue 4 of Clinical Science , Liu et al. showed that neutrophils release extracellular traps (NETs) in the setting of diabetes which acts as a stimulus for NLRP3 inflammasome activation in macrophages...
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Clin Sci (Lond) (2020) 134 (12): 1449–1456.
Published: 18 June 2020
...Parimala Narne Hepatitis C virus (HCV) infection and chronic hepatitis C (CHC) are associated with a measurable risk of insulin resistance (IR)/impaired glucose tolerance (IGT)/diabetes mellitus (DM). While loss of hepatic endocrine function contributes to liver cirrhosis in diabetic patients...
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Clin Sci (Lond) (2020) 134 (11): 1255–1258.
Published: 05 June 2020
...Qingzhang Zhu Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong et al. highlighted the critical...
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Clin Sci (Lond) (2020) 134 (8): 1031–1048.
Published: 27 April 2020
... marrow (BM). Specifically, we summarize current knowledge about the origin and function of BM adipose tissue (BMAT), provide evidence for the association of excess BMAT with diabetes and related cardiovascular complications, and discuss potential therapeutic approaches to correct BMAT dysfunction...
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Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
...Rim Rafeh; Anissa Viveiros; Gavin Y. Oudit; Ahmed F. El-Yazbi Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food intake triggered steep increase in the incidence of metabolic disorders including obesity and Type 2 diabetes. Patients with metabolic disease...
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Clin Sci (Lond) (2020) 134 (5): 529–542.
Published: 13 March 2020
...Jizheng Chen; Fang Wang; Yue Zhou; Jing Jiang; Sulaiman Ksimu; Xu Zhang; John Zhong Li; Junqi Niu; Qian Wang Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
...Rachel Njeim; Theresa Farhat; Sahar Alkhansa; Natalie Youssef; Batoul Dia; Rasha Slika; Radwan Diab; Sami T. Azar; Assaad A. Eid Diabetic kidney disease is one of the most serious complications of diabetes worldwide and is the leading cause of end-stage renal disease. While research has primarily...
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Clin Sci (Lond) (2019) 133 (14): 1603–1607.
Published: 22 July 2019
...Sonu Bhaskar Diabetes is associated with poor recovery profiles following stroke. The pathophysiological mechanisms by which diabetes mediates neurological recovery after stroke are debatable. A recent paper published in the Clinical Science by Pintana et al. (Clinical Science (2019) 133 , 1367...
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Clin Sci (Lond) (2019) 133 (12): 1321–1339.
Published: 20 June 2019
...Jia Guo; Zhangsuo Liu; Rujun Gong Diabetic kidney disease (DKD) is among the most common complications of diabetes mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in developed countries, with no definitive therapy yet available. It is imperative to decipher...
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Clin Sci (Lond) (2019) 133 (2): 351–365.
Published: 30 January 2019
...Catalina Atorrasagasti; Agostina Onorato; María L. Gimeno; Luz Andreone; Mariana Garcia; Mariana Malvicini; Esteban Fiore; Juan Bayo; Marcelo J. Perone; Guillermo D. Mazzolini Obesity, metabolic syndrome, and type 2 diabetes, three strongly interrelated diseases, are associated to increased...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (2): 195–203.
Published: 18 January 2019
... atherosclerosis remains the principal cause of morbidity and premature mortality in patients with diabetes, and the burden of vascular complications is greatly enhanced by prior periods of inadequate control of blood glucose. Recent findings suggest that long-term changes in bone marrow myeloid progenitors...
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Clin Sci (Lond) (2019) 133 (1): 41–54.
Published: 03 January 2019
...Alessandro Pini; Roberta Verta; Cristina Grange; Maura Gurrieri; Arianna Carolina Rosa The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties...
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Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
... of host metabolic diseases including obesity, cardiovascular, diabetes, and fatty liver disease. This disruption is often referred to as gut dysbiosis. Gut dysbiosis leads to altered metabolic products derived from the microbiota and these in turn, typically shift the homeostatic metabolic balance...
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Clin Sci (Lond) (2018) 132 (2): 185–198.
Published: 19 January 2018
...Zafer Gurel; Nader Sheibani The incidence of diabetes continues to rise among all ages and ethnic groups worldwide. Diabetic retinopathy (DR) is a complication of diabetes that affects the retinal neurovasculature causing serious vision problems, including blindness. Its pathogenesis and severity...
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Clin Sci (Lond) (2017) 131 (16): 2079–2094.
Published: 24 July 2017
... involvement of each of these steps has been amassed from genetic mouse models, where forcing the heart to metabolize too much or too little fat was accompanied by cardiac contractile dysfunction and hypertrophy. In cardiac pathologies, such as heart disease and diabetes, aberrations in FA metabolism occur...
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Clin Sci (Lond) (2017) 131 (12): 1245–1260.
Published: 07 June 2017
...Erik Westein; Thomas Hoefer; Anna C. Calkin Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes (T2D). This condition is associated with heightened platelet reactivity, contributing to increased atherothrombotic risk. Indeed, individuals with diabetes respond...
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Clin Sci (Lond) (2017) 131 (10): 981–990.
Published: 04 May 2017
... and are the common denominator for various diseases including diabetes-associated macro-/micro-vascular complications and hypertension. A range of enzymes are capable of generating ROS, but the pro-oxidant enzyme family, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), are the only enzymes known...
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Clin Sci (Lond) (2016) 130 (21): 1901–1911.
Published: 22 September 2016
... reported in multiple tissues, we have investigated the potential role of Netrin-1 in the endocrine islet and its implication in mice with high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Effects of exogenous Netrin-1 on β-cell [Ca 2+ ] i , cyclic AMP (cAMP) and insulin production were assessed...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (20): 1807–1822.
Published: 15 September 2016
...Trevor Hardigan; Rebecca Ward; Adviye Ergul The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients...
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Clin Sci (Lond) (2016) 130 (19): 1677–1696.
Published: 23 August 2016
... by glyoxalase 1. The GLO1 gene encoding glyoxalase 1 has low prevalence duplication and high prevalence amplification in some tumours. Dicarbonyl stress contributes to aging, disease and activity of cytotoxic chemotherapeutic agents. It is found at a low, moderate and severe level in obesity, diabetes and renal...
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Clin Sci (Lond) (2016) 130 (2): 79–91.
Published: 04 December 2015
... effects on various tissues, regulating energy absorption and disposal, as well as cell proliferation and survival. In Type 2 Diabetes (T2D) reduced plasma levels of GLP-1 have been observed, and plasma levels of GLP-1, as well as reduced numbers of GLP-1 producing cells, have been correlated to obesity...
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Clin Sci (Lond) (2015) 129 (11): 933–949.
Published: 10 September 2015
... adrenergic receptor brown adipose tissue browning diabetes obesity white adipose tissue Obesity is a status of chronic positive energy balance associated with excess fat storage resulting from energy intake exceeding energy expenditure. Excess fat that first accumulates in adipose tissues...
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