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1-43 of 43
Keywords: Diabetic nephropathy
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Articles
Federica Barutta, Beatrice Corbetta, Stefania Bellini, Roberto Gambino, Stefania Bruno, Shunsuke Kimura, Koji Hase, Hiroshi Ohno, Gabriella Gruden
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1537–1559.
Published: 29 November 2024
...Federica Barutta; Beatrice Corbetta; Stefania Bellini; Roberto Gambino; Stefania Bruno; Shunsuke Kimura; Koji Hase; Hiroshi Ohno; Gabriella Gruden Mitochondrial dysfunction plays an important role in the development of podocyte injury in diabetic nephropathy (DN). Tunnelling nanotubes (TNTs...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (16): 991–1007.
Published: 14 August 2024
... and p16 expression are increased in Type 2 diabetic nephropathy biopsies compared with normal age-matched control tissues, supporting the presence of increased cellular senescence in DKD [ 90 ]. Furthermore, the markers of senescence are more pronounced in tubular cells than in glomeruli [ 90...
Articles
Ming Yang, Qin Zhang, Shilu Luo, Yachun Han, Hao Zhao, Na Jiang, Yan Liu, Li Li, Chenrui Li, Chongbin Liu, Liyu He, Xuejing Zhu, Yu Liu, Lin Sun
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (12): 931–945.
Published: 20 June 2023
... of diabetic nephropathy (DN). DsbA-L is mainly located in MAMs and plays a role in renoprotection, but whether it activates mitophagy by maintaining MAM integrity remains unclear. In the present study, we found that renal tubular damage was further aggravated in diabetic DsbA-L −/− mice compared with diabetic...
Includes: Supplementary data
Articles
Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 87–104.
Published: 05 January 2023
... are senior authors. 29 06 2022 15 12 2022 15 12 2022 16 12 2022 Diabetic nephropathy Empagliflozin NHE3 Proteomics RAS blockade SGLT2i Diabetic nephropathy (DN) is a renal microvascular complication of diabetes mellitus (DM). Currently, 537 million people around...
Includes: Supplementary data
Articles
William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1485–1511.
Published: 03 November 2022
... of the Biochemical Society 2022 diabetic nephropathy fatty acid oxidation peroxisome proliferator-activated receptors preclinical transcriptomics weight loss In the ZDF study, plasma total cholesterol (WAKO 294-65801) and triglycerides (Cayman Chemical 10010303) were measured at 8-week follow-up...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
...Federica Barutta; Stefania Bellini; Gabriella Gruden Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN). Moreover, albuminuria is an important feature...
Articles
Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... 4.0 (CC BY) . Open access for this article was enabled by the participation of Monash University in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. diabetic nephropathy inflammation MCC950 NLRP3...
Includes: Supplementary data
Articles
Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Published: 25 September 2020
...Zhuo Li; Hua Guo; Jia Li; Tianjiao Ma; Shanshan Zhou; Zhiguo Zhang; Lining Miao; Lu Cai Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase (AMPK) can attenuate...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
Articles
Runa S.J. Lindblom, Gavin C. Higgins, Tuong-Vi Nguyen, Maryann Arnstein, Darren C. Henstridge, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Mark E. Cooper, Josephine M. Forbes, Melinda T. Coughlan
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 239–259.
Published: 29 January 2020
... Society under a transformative agreement with CAUL. cell death cyclophilin D diabetic nephropathy mitochondria mitochondrial permeability transition pores Chronic kidney disease (CKD) is recognised as a leading cause of morbidity and mortality amongst the 425 million people estimated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... of diabetes are also recognized. The causes include genetic defects in β-cells and insulin action, diseases of the pancreas, endocrine pathologies, drug-induced reactions and infections [ 10 ]. cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
... of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia. 14 08 2018 04 12 2018 07 01 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 chronic kidney disease diabetic nephropathy transforming...
Articles
Wenxia Yang, Ying Luo, Shikun Yang, Mengru Zeng, Shumin Zhang, Jialu Liu, Yuzhang Han, Yu Liu, Xuejing Zhu, Hao Wu, Fuyou Liu, Lin Sun, Li Xiao
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2407–2422.
Published: 22 November 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ADRP diabetic nephropathy ectopic lipid accumulation sterol regulatory element-binding proteins tubular injury Diabetic kidney disease (DKD) is a common complication...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1329–1339.
Published: 28 June 2018
... by Portland Press Limited on behalf of the Biochemical Society 2018 diabetic nephropathy glucose transport renal physiology Type 2 diabetes mellitus (T2DM) is a major public health concern [ 1 ]. The main feature of T2DM is chronic or periodic hyperglycemia which in turn can lead...
Articles
Ming Zhan, Irtaza Usman, Jingbo Yu, Liemin Ruan, Xueyan Bian, Jun Yang, Shikun Yang, Lin Sun, Yashpal S. Kanwar
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
...Ming Zhan; Irtaza Usman; Jingbo Yu; Liemin Ruan; Xueyan Bian; Jun Yang; Shikun Yang; Lin Sun; Yashpal S. Kanwar Renal tubular injury is increasingly being recognized as an early characteristic of diabetic nephropathy (DN). Mitochondrial dynamic alterations and redox protein p66Shc-mediated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... to determine IR, this review article will focus on imaging techniques that could be utilized to determine renal IR and that could be tested to predict kidney disease development and progression. Correspondence: Alessia Fornoni ( [email protected] ) diabetic nephropathy diagnostics functional...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2183–2199.
Published: 31 July 2017
... 30–40% of patients with diabetes develop nephropathy and this renal injury normally progresses in about a third of patients. Due to the growing incidence of diabetes, diabetic nephropathy is now the main cause of end-stage renal disease (ESRD) worldwide. Accumulating evidence from experimental...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (5): 411–423.
Published: 17 February 2017
... 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic nephropathy kidney fibrosis mesangial cells microRNA (miRNA) transforming growth factor-β (TGF-β1) • Diabetic nephropathy (DN) is the leading cause...
Includes: Supplementary data
Articles
Melinda T. Coughlan, Tuong-Vi Nguyen, Sally A. Penfold, Gavin C. Higgins, Vicki Thallas-Bonke, Sih Min Tan, Nicole J. Van Bergen, Karly C. Sourris, Brooke E. Harcourt, David R. Thorburn, Ian A. Trounce, Mark E. Cooper, Josephine M. Forbes
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (9): 711–720.
Published: 18 March 2016
...; published by Portland Press Limited 2016 We identified that dysfunction of cellular power stations, mitochondria, may precede the development of kidney disease in diabetes. This suggests that mitochondrial dysfunction is a primary cause of diabetic nephropathy, which could be targeted to improve...
Articles
Aaron D. McClelland, Michal Herman-Edelstein, Radko Komers, Jay C. Jha, Catherine E. Winbanks, Shinji Hagiwara, Paul Gregorevic, Phillip Kantharidis, Mark E. Cooper
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1237–1249.
Published: 11 November 2015
...Aaron D. McClelland; Michal Herman-Edelstein; Radko Komers; Jay C. Jha; Catherine E. Winbanks; Shinji Hagiwara; Paul Gregorevic; Phillip Kantharidis; Mark E. Cooper The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic nephropathy (DN) with data implicating the miRNA...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (10): 685–694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (10): 707–720.
Published: 27 January 2014
... 24 h. Activity of the RAS (renin–angiotensin system) is elevated both in the circulation and renal tissue of patients with diabetic nephropathy. Increased activity of the RAS plays an important role in the haemodynamic and non-haemodynamic pathogenetic mechanisms involved in kidney injury...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (11): 685–694.
Published: 15 February 2013
... for therapeutic management in a setting of chronic kidney disease. COX (cyclo-oxygenase)-derived PGs (prostaglandins) are implicated in diabetic nephropathy, but their role has yet to be defined: initiating diabetic features or antagonizing other pathophysiological agents such as the RAS (renin–angiotensin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (9): 553–566.
Published: 21 January 2013
...Radko Komers Inhibition of the RAAS (renin–angiotensin–aldosterone system) plays a pivotal role in the prevention and treatment of diabetic nephropathy and a spectrum of other proteinuric kidney diseases. Despite documented beneficial effects of RAAS inhibitors in diabetic patients with nephropathy...
Articles
Naohito Ishii, Pamela K. Carmines, Masanori Yokoba, Hiroyuki Imaizumi, Tsuyoshi Ichikawa, Hideki Ikenagasa, Yoshio Kodera, Masamichi Oh-Ishi, Yoshikazu Aoki, Tadakazu Maeda, Tsuneo Takenaka, Masato Katagiri
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (8): 543–552.
Published: 08 January 2013
..., pH 3.1 (0.75 ml/min). The retention time of 3-NT is 34 min (tyrosine: 11 min). Free 3-NT concentration in renal cortex is expressed as pmol/mg of protein. diabetic nephropathy mitochondrial proteins nitric oxide 3-nitrotyrosine oxidative stress proteomic analysis • During...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... [email protected] ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (3): 153–164.
Published: 05 October 2012
..., inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (3): 139–152.
Published: 02 October 2012
...Jun Wada; Hirofumi Makino The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous...
Articles
Antonio Rivero, Carmen Mora, Mercedes Muros, Javier García, Havidian Herrera, Juan F. Navarro-González
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (6): 479–492.
Published: 12 February 2009
...Antonio Rivero; Carmen Mora; Mercedes Muros; Javier García; Havidian Herrera; Juan F. Navarro-González Diabetes and its complications have become a public health problem. One of the most important complications is diabetic nephropathy, which is nowadays the main cause of chronic renal failure...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (1): 81–86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
...Jichun Yang; Dongjuan Zhang; Jing Li; Xiaoyan Zhang; Fenling Fan; Youfei Guan DN (diabetic nephropathy) is a chronic disease characterized by proteinuria, glomerular hypertrophy, decreased glomerular filtration and renal fibrosis with loss of renal function. DN is the leading cause of ESRD (end...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
...David Z. Levine In the past, hyperfiltration and increased glomerular capillary pressure have been identified as important determinants of the development of DN (diabetic nephropathy). Recently, some basic research and clinical reviews on DN have omitted identifying hyperfiltration as an important...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
... glucose tolerance and the development of glomerular hyperfiltration and microalbuminuria, ultimately leading to diabetic nephropathy and end-stage renal disease. Clinical studies have suggested that an inappropriate increase in hyperglycaemic glucagon (hyperglucagonaemia) over hypoglycaemic insulin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (1): 69–75.
Published: 10 December 2001
... contribute to the increased incidence of cardiovascular disease, was investigated. PMA-stimulated expression of CD11b and CD69 on neutrophils from normal controls (NC), long-term uncomplicated Type I diabetic control patients (DC) and diabetic nephropathy patients (DN) was determined by fluorescence...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (6): 591–599.
Published: 25 April 2001
...Zemin CAO; Fabrice BONNET; Belinda DAVIS; Terri J. ALLEN; Mark E. COOPER Angiotensin II plays a pivotal role in the development of diabetic nephropathy, but it remains controversial as to the best approach to effectively block the actions of this hormone in the kidney. The aim of the present study...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (5): 511–516.
Published: 01 May 1998
... accumulation. This difference does not result from differences in glomerular-converting enzyme activity. 13 11 1997 12 12 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 angiostensin-converting enzyme inhibitors diabetic nephropathy glomerular angiotensin...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (2): 165–173.
Published: 01 February 1998
...Robert Zietse; Frans H. Derkx; Willem Weimar; Maarten A. Schalekamp 1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (4): 421–426.
Published: 01 April 1995
... resistance arterioles or the efferent glomerular arterioles, this could lead to systemic and intraglomerular hypertension, factors which may contribute to the development of diabetic nephropathy. 1 12 1994 15 12 1994 © 1995 The Biochemical Society and the Medical Research Society 1995...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (1): 19–23.
Published: 01 January 1992
...% of all insulin-dependent and non-insulin-dependent diabetic patients suffer from diabetic nephropathy, which is a clinical syndrome characterized by persistent albumin- uria, a progressive decline in glomerular filtration rate (GFR) and high blood pressure [ 1,3]. Both a reduction in protein intake...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1989) 77 (5): 521–527.
Published: 01 November 1989
... months of diabetes. The median fractional mesangial area was 44.8% in the diabetic Lewis rats and 31.4% in the diabetic DA rats. 6. These results suggest that Lewis rats possess an inherited susceptibility to diabetic nephropathy, and that DA rats are relatively resistant. These differences...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 71 (2): 217–220.
Published: 01 August 1986
... and the Medical Research Society 1986 angiotensin II diabetes mellitus diabetic nephropathy platelets, receptors ClinicalScience(l986) 71, 217-220 SHORT COMMUNICATION 217 Reduced number of angiotensin I1 receptors on platelets in insulin-dependent diabetes J. M. C. CONNELL, YU-AN DING*, B. M. FISHER...
