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1-7 of 7
Keywords: EMT
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Articles
PDCD10/CCM3, a potential target for pancreatic ductal adenocarcinoma?
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (03): 281–286.
Published: 04 February 2025
... -/- ) engineered to homozygously lack PDCD10 showed that PDCD10 renders cells more chemoresistant to anticancer drugs. Moreover, PDCD10 promoted TGF-β1-dependent proliferation by inactivating the retinoblastoma 1 protein (pRb) via a SMAD4-dependent pathway, and TGF-β1-driven EMT by increasing ERK1/2 activation via...
Articles
Stress signaler p38 mitogen-activated kinase activation: a cause for concern?
Available to PurchaseIn Collection
Reproductive Physiology and Disease
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1591–1614.
Published: 14 November 2022
... the human fetal membrane’s amnion epithelial cells (AEC). We created p38 KO AEC using the CRISPR/Cas9 approach and tested cell fate in response to OS on an AEC-free fetal membrane extracellular matrix (ECM). Screening using image CyTOF indicated OS causing epithelial–mesenchymal transition (EMT). Further...
Includes: Supplementary data
Articles
Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization
Available to PurchaseChuanjian Suo, Zeping Gui, Zijie Wang, Jiajun Zhou, Ming Zheng, Hao Chen, Shuang Fei, Min Gu, Ruoyun Tan
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 53–69.
Published: 05 January 2021
... 2020 08 12 2020 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Bortezomib chronic allograft dysfunction EMT IκBα kidney transplantation In recent years, the short-term survival rate of renal allografts has been...
Includes: Supplementary data
Articles
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway
Available to PurchaseXiaohong Sun, Kaipeng Huang, Xiao Haiming, Zeyuan Lin, Yan Yang, Meng Zhang, Peiqing Liu, Heqing Huang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1573–1592.
Published: 30 June 2020
...Xiaohong Sun; Kaipeng Huang; Xiao Haiming; Zeyuan Lin; Yan Yang; Meng Zhang; Peiqing Liu; Heqing Huang Hyperglycemia-induced renal epithelial-to-mesenchymal transition (EMT) is a key pathological factor in diabetic renal tubulointerstitial fibrosis (RIF). Our previous studies have shown...
Articles
Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression
Available to PurchaseYiting Geng, Xiao Zheng, Wenwei Hu, Qi Wang, Yanjie Xu, Wenting He, Chen Wu, Danxia Zhu, Changping Wu, Jingting Jiang
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (10): 1197–1213.
Published: 30 May 2019
... the proliferation, epithelial–mesenchymal transition (EMT), migration, and invasion of CRC cells. Hsa_circ_0009361 was identified as the sponge of miR-582 by fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP), and luciferase reporter assays. Overexpression of hsa_circ_0009361 up-regulated...
Includes: Supplementary data
Articles
Melatonin suppresses lung cancer metastasis by inhibition of epithelial–mesenchymal transition through targeting to Twist
Available to PurchaseChia-Chia Chao, Po-Chun Chen, Pei-Chen Chiou, Chin-Jung Hsu, Po-I Liu, Yi-Chen Yang, Russel J. Reiter, Shun-Fa Yang, Chih-Hsin Tang
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (5): 709–722.
Published: 15 March 2019
...Chia-Chia Chao; Po-Chun Chen; Pei-Chen Chiou; Chin-Jung Hsu; Po-I Liu; Yi-Chen Yang; Russel J. Reiter; Shun-Fa Yang; Chih-Hsin Tang The epithelial–mesenchymal transition (EMT) phenotype, whereby mature epithelial cells undergo phenotype transition and differentiate into motile, invasive cells, has...
Articles
MKP2 suppresses TGF-β1-induced epithelial-to-mesenchymal transition through JNK inhibition
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (3): 545–550.
Published: 13 February 2019
...Ivonne Loeffler Interstitial fibrosis is a typical feature of end-stage renal diseases, regardless of the initial cause of kidney injury. Epithelial-to-mesenchymal transition (EMT) is a mechanism that is thought to play a role in generating the interstitial matrix-producing myofibroblasts...
