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Keywords: ER stress
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Clin Sci (Lond) (2021) 135 (23): 2643–2658.
Published: 08 December 2021
...). To evaluate the effects of IS in the AKI-to-CKD transition, we administered indole, a precursor of IS, at the early stage of UIRI. Our results demonstrated IS potentiates renal fibrosis, senescence-associated secretory phenotype (SASP), and activation of endoplasmic reticulum (ER) stress, which is attenuated...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (14): 1911–1934.
Published: 23 July 2020
... to be reduced in CF airways. In the present study, we sought to investigate the upstream mechanisms repressing PPARγ expression and its impact on airway epithelial host defense. Endoplasmic reticulum-stress (ER-stress) triggered unfolded protein response (UPR) activated by misfolded CFTR and P. aeruginosa...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (11): 1255–1258.
Published: 05 June 2020
... role of endoplasmic reticulum (ER) stress-autophagy axis in maintaining cognitive functions and provided pharmacological evidence with respect to cognitive improvements in a diabetic mouse model. These novel findings present new insights into the pathological mechanisms and therapeutic implications...
Clin Sci (Lond) (2019) 133 (19): 2023–2028.
Published: 11 October 2019
...) pathogenesis remain largely unknown. In a recent issue of Clinical Science , Navas-Madronal et al. ((2019), 133 (13), 1421–1438) reported that enhanced ER stress and dysregulation of mitochondrial biogenesis are associated with AAA pathogenesis in humans. The authors also proposed that disruption in oxysterols...
Clin Sci (Lond) (2016) 130 (21): 1881–1888.
Published: 22 September 2016
... in endoplasmic reticulum (ER) stress and, in animal studies, ER stress has been implicated as a cause of endothelial dysfunction. In the present study, we tested the hypothesis that acute oral administration of tauroursodeoxycholic acid (TUDCA, 1500 mg), a chemical chaperone known to alleviate ER stress, would...
Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... Press Limited 2015 24p3 autophagy cardiomyopathy ER stress heart failure iron deficiency iron overload lipocalin 2 (Lcn2) mitochondrial dysfunction NGAL oxidative stress In recent years there have been several clinical trials to test whether administration of intravenous iron...