...Motoyuki IEMITSU; Takashi MIYAUCHI; Seiji MAEDA; Takumi TANABE; Yoko IRUKAYAMA-TOMOBE; Katsutoshi GOTO; Mitsuo MATSUDA; Iwao YAMAGUCHI Endothelin-1 (ET-1) is produced by endothelial cells and cardiac myocytes. ET-1 has potent positive inotropic and chronotropic effects on heart and induces...

...Andrew T. GOODWIN; Mahboob A. KHAN; Adrian H. CHESTER; Mohamed AMRANI; Magdi H. YACOUB Endothelin-1 (ET-1) is believed to play an important role in cardiac ischaemia/reperfusion injury. ET-1 is synthesized from preproET-1 by the action of ET-converting enzyme (ECE). It is unclear to what extent...

... the expression of GAPDH, HIF-1α and endothelin-1 (ET-1), and increased [ 3 H]palmitate uptake. These findings indicate that the intrinsic energy metabolic system in cultured cardiomyocytes in vitro is predominantly glycolysis, and that the gene expression of cardiac ET-1 parallels the state of the glycolytic...

...Torsten SLOWINSKI; Hans-H. NEUMAYER; Thomas STOLZE; Gabriele GOSSING; Horst HALLE; Berthold HOCHER Pre-eclampsia complicates approximately 5–7% of pregnancies and it may be deleterious to both maternal and fetal health. In a prospective study, we investigated plasma endothelin (ET)-1 concentration...