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1-13 of 13
Keywords: Endoplasmic reticulum stress
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
.... Emerging evidence has demonstrated that absent in melanoma 2 (AIM2)-mediated inflammasome activation and endoplasmic reticulum stress (ERS) play a pivotal role in the renal fibrosis. Here, we investigated whether overexpression or deficiency of AIM2 affects ERS and fibrosis in aldosterone-infused renal...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2467–2481.
Published: 01 November 2021
... binding protein 1 (xbp1s), a key component of endoplasmic reticulum stress (ERS), contributes to the pathogenesis of PH. Forty male SD rats were randomly assigned to four groups: Control, Monocrotaline (MCT), MCT+AAV-CTL (control), and MCT+AAV-xbp1s. The xbp1s protein levels were found to be elevated...
Articles
Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1689–1706.
Published: 20 July 2021
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bile acids Endoplasmic reticulum stress Glycoursodeoxycholic acid Metabolic disorders Metabolic disorders including type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver disease...
Includes: Supplementary data
Articles
Beatriz Delgado-Valero, Lucía de la Fuente-Chávez, Ana Romero-Miranda, María Visitación Bartolomé, Bunty Ramchandani, Fabián Islas, María Luaces, Victoria Cachofeiro, Ernesto Martínez-Martínez
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
.... The interface voltage was maintained at 3.5 kV. Nitrogen was used as nebulizing and drying gas at a flow of 1.5 and 15 l/min, respectively. Argon was used as collision gas at 230 kPa. endoplasmic reticulum stress myocardial infarction renal fibrosis Kidneys and heart are linked since the heart...
Includes: Supplementary data
Articles
Jiaxi Chen, Tongtian Zhuang, Jianru Chen, Yangzi Tian, Xiuli Yi, Qingrong Ni, Weigang Zhang, Pu Song, Zhe Jian, Ling Liu, Tingting Cui, Kai Li, Tianwen Gao, Chunying Li, Shuli Li
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (10): 1127–1141.
Published: 21 May 2020
.... apoptosis endoplasmic reticulum stress folic acid homocysteine melanocytes Vitiligo Vitiligo is an acquired, chronic depigmentation disorder [ 1 ]. The primary physical symptom is patchy depigmentation on the skin, the mucous membranes and occasionally in some hair bulbs, which is characterized...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (5): 459–472.
Published: 04 March 2020
... endoplasmic reticulum stress in the syncytiotrophoblast in a manner that involved caspase 8 and TNF-α. To avoid accumulation of the associated misfolded proteins and MLKL, the syncytiotrophoblast exports these potentially dangerous proteins in EVs. It is likely that the dangerous proteins that are loaded...
Articles
Miquel Navas-Madroñal, Cristina Rodriguez, Modar Kassan, Joan Fité, José R. Escudero, Laia Cañes, José Martínez-González, Mercedes Camacho, María Galán
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1421–1438.
Published: 05 July 2019
... as previously described [ 29 ]. abdominal aortic aneurysm endoplasmic reticulum stress mitochondrial biogenesis oxysterols An abdominal aortic aneurysm (AAA) is defined as a focal dilation of 50 percent greater than the normal average diameter of an aorta. It is a complex disease involving...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 167–180.
Published: 18 January 2019
...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 endoplasmic reticulum stress kidney molecular chaperones systemic lupus erythematosis Systemic lupus erythematosus (SLE) is a frequently debilitating autoimmune disease mainly affecting women, with onset typically...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (8): 883–899.
Published: 30 April 2018
... 2018 01 03 2018 20 03 2018 23 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 C1q/TNF-related protein 3 endoplasmic reticulum stress High-fat diet spermatogenesis silence information regulator 1...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 111–125.
Published: 11 January 2018
... on behalf of the Biochemical Society 2018 Autophagy Cognitive decline Diabetes Endoplasmic reticulum stress Neuronal apoptosis An increasing body of evidence supports the view that diabetic patients present a high risk of developing cognitive disorders [ 1 , 2 ]. Nowadays, diabetes...
Articles
Takashi Obama, Toshiyuki Tsuji, Tomonori Kobayashi, Yamato Fukuda, Takehiko Takayanagi, Yoshinori Taro, Tatsuo Kawai, Steven J. Forrester, Katherine J. Elliott, Eric Choi, Alan Daugherty, Victor Rizzo, Satoru Eguchi
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (9): 559–565.
Published: 11 February 2015
... in humans. In conclusion, EGFR inhibition appears to protect mice from AAA formation induced by Ang II plus BAPN. The mechanism seems to involve suppression of vascular EGFR and ER stress. abdominal aortic aneurysm angiotensin II endoplasmic reticulum stress hypertension rupture signal...
Includes: Supplementary data
Articles
Vanessa Legry, Derrick M. Van Rooyen, Barbara Lambert, Christine Sempoux, Laurence Poekes, Regina Español-Suñer, Olivier Molendi-Coste, Yves Horsmans, Geoffrey C. Farrell, Isabelle A. Leclercq
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (7): 507–518.
Published: 25 June 2014
... developing simple steatosis, endoplasmic reticulum stress does not contribute to the pathogenesis of insulin resistance and steatohepatitis in high-fat-diet-fed foz/foz mice, which develop progressive liver disease in the metabolic context seen in human non-alcoholic steatohepatitis. apoptosis...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (2): 99–111.
Published: 15 December 2008
... 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 endoplasmic reticulum stress inflammation mitochondrion obesity pancreatic β-cell Type 2 diabetes T2DM (Type 2 diabetes mellitus) in the United States and around the world has reached epidemic...