.... Emerging evidence has demonstrated that absent in melanoma 2 (AIM2)-mediated inflammasome activation and endoplasmic reticulum stress (ERS) play a pivotal role in the renal fibrosis. Here, we investigated whether overexpression or deficiency of AIM2 affects ERS and fibrosis in aldosterone-infused renal...

... binding protein 1 (xbp1s), a key component of endoplasmic reticulum stress (ERS), contributes to the pathogenesis of PH. Forty male SD rats were randomly assigned to four groups: Control, Monocrotaline (MCT), MCT+AAV-CTL (control), and MCT+AAV-xbp1s. The xbp1s protein levels were found to be elevated...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bile acids Endoplasmic reticulum stress Glycoursodeoxycholic acid Metabolic disorders Metabolic disorders including type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver disease...

... 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 endoplasmic reticulum stress myocardial infarction renal fibrosis Kidneys and heart are linked since the heart provides nutrients and oxygen to support normal kidney function. Moreover...

... contributed equally to this work. 01 03 2020 03 05 2020 13 05 2020 13 05 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 apoptosis endoplasmic reticulum stress folic acid homocysteine melanocytes Vitiligo...

... endoplasmic reticulum stress in the syncytiotrophoblast in a manner that involved caspase 8 and TNF-α. To avoid accumulation of the associated misfolded proteins and MLKL, the syncytiotrophoblast exports these potentially dangerous proteins in EVs. It is likely that the dangerous proteins that are loaded...

... 04 2019 22 06 2019 24 06 2019 24 06 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 abdominal aortic aneurysm endoplasmic reticulum stress mitochondrial biogenesis oxysterols An abdominal aortic aneurysm...

... M.J. ( 2017 ) Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis . Clin. Immunol. 185 , 59 – 73 10.1016/j.clim.2016.08.010 27519955 8. Cybulsky A.V. ( 2017 ) Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney...

... 2018 01 03 2018 20 03 2018 23 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 C1q/TNF-related protein 3 endoplasmic reticulum stress High-fat diet spermatogenesis silence information regulator 1...

... on behalf of the Biochemical Society 2018 Autophagy Cognitive decline Diabetes Endoplasmic reticulum stress Neuronal apoptosis An increasing body of evidence supports the view that diabetic patients present a high risk of developing cognitive disorders [ 1 , 2 ]. Nowadays, diabetes...

... in humans. In conclusion, EGFR inhibition appears to protect mice from AAA formation induced by Ang II plus BAPN. The mechanism seems to involve suppression of vascular EGFR and ER stress. abdominal aortic aneurysm angiotensin II endoplasmic reticulum stress hypertension rupture signal...

... developing simple steatosis, endoplasmic reticulum stress does not contribute to the pathogenesis of insulin resistance and steatohepatitis in high-fat-diet-fed foz/foz mice, which develop progressive liver disease in the metabolic context seen in human non-alcoholic steatohepatitis. apoptosis...

... 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 endoplasmic reticulum stress inflammation mitochondrion obesity pancreatic β-cell Type 2 diabetes T2DM (Type 2 diabetes mellitus) in the United States and around the world has reached epidemic...