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Keywords: Endothelial cells
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Clin Sci (Lond) (2023) 137 (18): 1451–1476.
Published: 21 September 2023
..., of lymphatic insufficiency can all manifest as edema. Figure 5 Summary of several different mechanisms that can lead to edema Inflammatory mediators cause partial disruption of endothelial cell–cell junctions, shedding of the luminal glycocalyx, and decreased junctional lamellipodia activity at cell...
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Clin Sci (Lond) (2023) 137 (8): 597–601.
Published: 19 April 2023
... review what is known about the relationship between the activation of the immune and lymphatic systems, and the resulting effects on systemic blood pressure, summarize the findings published by Goodlett and collaborators, and discuss the impact of their findings on the field. endothelial cells...
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Clin Sci (Lond) (2022) 136 (17): 1281–1301.
Published: 05 September 2022
... and quantified rat ASC-exosome miRNAs and used bioinformatics to select uncharacterized miRNAs down-regulated in post-MI related to cardiac repair. We selected and validated miR-196a-5p and miR-425-5p as candidates for the concerted response in neonatal cardiomyocytes, cardiac fibroblasts, endothelial cells...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
... is important in the vascular system where it is found in arterial and venous endothelial cells and arterial smooth muscle cells in many vascular beds. Among the best characterized functions of ACE2 is its role in regulating vascular tone. ACE2 through its effector peptide Ang-(1-7) and receptor Mas1 induces...
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Clin Sci (Lond) (2019) 133 (12): 1353–1365.
Published: 20 June 2019
... translocator (ARNT) is a key mediator of proper placental angiogenesis, and within placental endothelial cells (ECs) from human FGRadv pregnancies, low expression of ARNT leads to decreased vascular endothelial growth factor A (VEGFA) expression and deficient tube formation. Thus, the aim of the present study...
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Clin Sci (Lond) (2018) 132 (4): 437–447.
Published: 16 February 2018
... protein FKBP12. TGF receptor-type I (TGFRI) spontaneous activation is inhibited by the association with FKBP12. We hypothesized that rapamycin, in addition to inhibition of mTOR signaling, activates TGFRI independent of TGFβ. Human umbilical vein endothelial cells (HUVECs) were treated with rapamycin (10...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (15): 1763–1780.
Published: 05 July 2017
..., and enhanced migration and proliferation of choroidal endothelial cells (ChEC) in the retina rupturing through the Bruch's membrane. In the active phase, CNV starts to expand, either by remaining beneath the RPE or by entering the sub-retinal space ( Figure 1 ). Ultimately, in the end phase CNV becomes...
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Clin Sci (Lond) (2017) 131 (5): 369–379.
Published: 15 February 2017
...), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved–the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM–interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes...
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Clin Sci (Lond) (2015) 129 (12): 1225–1236.
Published: 11 November 2015
... filtration barrier Electron microscopy images ( A : scanning, B and C : transmission) of the glomerular capillary filtration barrier. Podocyte (POD), endothelial cells (EC), GBM, endothelial surface layer–glycocalyx (ESL) (pictures courtesy of Dr Kathryn E White, University of Newcastle, U.K...
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Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
Published: 01 September 2002
... of atherosclerosis. We therefore subjected cultured human umbilical vein endothelial cells and coronary artery smooth muscle cells to oxidative stress induced by xanthine oxidase or hydrogen peroxide and observed alterations in ET-1 metabolism. Incubation with oxygen-derived free radicals increased preproET-1...
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Clin Sci (Lond) (2002) 103 (s2002): 9S–12S.
Published: 01 September 2002
... in experimental studies. Another potent pro-atherosclerotic risk factor is oxidized low-density lipoprotein (oxLDL). Endothelial cells mediate the uptake of oxLDL by the recently identified lectin-like oxLDL receptor-1 (LOX-1), which accumulates in atherosclerotic lesions. In the present study, we analysed...
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Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
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Clin Sci (Lond) (1995) 88 (2): 135–139.
Published: 01 February 1995
... pathophysiology [ 1, 21. Endogenous NO is formed from the semiessential amino acid L-arginine by NO synthase (NOS), of which three main iso- forms have been described. Constitutive forms of NOS (cNOS) are found in endothelial cells and produce NO that is responsible for endothelium- dependent vasodilatation...