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Keywords: Endothelin-1
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Articles
In Collection
Endothelin XVIII Conference Collection
John Miller Allan, Brandon M. Fox, Malgorzata Kasztan, Gillian C. Kelly, Patrick A. Molina, McKenzi A. King, Jackson Colson, Leigh Wells, Latanya Bowman, Marsha Blackburn, Abdullah Kutlar, Ryan A. Harris, David M. Pollock, Jennifer S. Pollock
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1505–1520.
Published: 26 November 2024
... for poor vascular health and vascular dysfunction. High levels of vascular reactive oxygen species (ROS) as well as elevated plasma endothelin-1 (ET-1), a potent vasoconstrictor with actions via the ET A receptor, are both common phenotypes in SCD. Alpha-1 adrenergic receptor activation is a major mediator...
Includes: Supplementary data
Articles
In Collection
Endothelin XVIII Conference Collection
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (21): 1329–1341.
Published: 24 October 2024
...Eda Karakaya; Yasir Abdul; Jazlyn Edwards; Sarah Jamil; Onder Albayram; Adviye Ergul Endothelin-1 (ET-1), the most potent vasoconstrictor identified to date, contributes to cerebrovascular dysfunction. ET-1 levels in postmortem brain specimens from individuals diagnosed with Alzheimer’s disease (AD...
Includes: Supplementary data
Articles
In Collection
Endothelin XVIII Conference Collection
Anna Flavia R. Lima, Daniel Rodrigues, Mirele R. Machado, José Teles Oliveira-Neto, Alecsander F. M. Bressan, Carina A. Pedersoli, Juliano V. Alves, Júlio A. Silva-Neto, Paula R. Barros, Thiago B. Dias, Luis V. Garcia, Ariane Bruder-Nascimento, Thiago Bruder-Nascimento, Fernando S. Carneiro, Luiz Osório S. Leiria, Rita C. Tostes, Rafael M. Costa
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1071–1087.
Published: 30 August 2024
... is the peptide endothelin-1 (ET-1), which induces oxidative stress and disrupts vascular function. The present study postulates that obesity augments ET-1 production in the PVAT, decreases the function of the nuclear factor erythroid 2-related factor-2 (Nrf2) transcription factor, further increasing reactive...
Articles
In Collection
Endothelin XVIII Conference Collection
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1009–1022.
Published: 21 August 2024
... ]. Additionally, pericytes have been identified to become inflammatory and undergo a microglial transition after ischemic stroke, which is a common risk factor for VCID [ 36 ]. However, this concept has not been investigated in diabetic conditions. Endothelin-1 (ET-1) is the most potent vasoconstrictor...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (11): 645–662.
Published: 29 May 2024
... well established. The few known physiologic actions, including natriuresis/diuresis and vasodilation, have been summarized previously by Bader and colleagues [ 18 ]. Angiotensin II Endothelin Type A receptor Endothelin-1 FSGS IgA nephropathy Sparsentan Travere Therapeutics, Inc...
Articles
In Collection
Clinical and translational research highlights
Simon T. Christensen, Kristian A. Haanes, Stine Spray, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson, Sara E. Johansson
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1797–1811.
Published: 20 August 2019
.... In both regimens, trametinib treatment caused significant reductions in the endothelin-1 induced contractility after SAH, which is believed to be associated with endothelin B receptor up-regulation. Trametinib treated rats showed improved neurological scores, evaluated by the ability to traverse...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1475–1486.
Published: 15 July 2019
... ). Previous studies have demonstrated that endothelin-1 (ET-1) contributes to P alb changes in models of diabetes and SCD. Thus, we performed longitudinal studies of renal function to determine the relationship between ET-1 and glomerular size and P alb that may contribute to hyperfiltration in humanized...
Articles
Junhui Shen, Zhong-Kai Cui, Fang Yao, Kai Li, Yue Zhang, Zhenguo Chen, Yuxia Zhou, Song Xu, Yuwei Zhang, Wenqing Jiang, Hanbin Zhang, Kaifen Tan, Anling Liu, Xiaochun Bai
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1 fl/fl control mice. Endothelin-1 (EDN1) and phospho-Jun-amino-terminal kinase (p-JNK) were up-regulated in Fibro-TSC1 −/− renal fibroblasts after LPS challenge. Rapamycin, an mTORC1 inhibitor, and bosentan, an EDN1 antagonist...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2777–2789.
Published: 23 November 2017
... vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ET B R). We evaluated ET-1 sensitivity, ET A R, and ET B R contributions to ET-1-mediated constriction, and the mechanistic role of ET B R in endothelium-dependent dilation in vivo in the microvasculature...
Articles
Barbara Schreier, Mirja Hünerberg, Sindy Rabe, Sigrid Mildenberger, Daniel Bethmann, Christian Heise, Maria Sibilia, Stefan Offermanns, Michael Gekle
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (1): 19–33.
Published: 30 November 2015
... development and extracellular-signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation in aortic rings from KO animals. By contrast, we observed no difference in force development during application of serotonin, KCl, endothelin-1 or endothelin-1-induced pressure load in KO animals. In addition, nitric oxide...
Includes: Supplementary data
Articles
Rocío López-Sepúlveda, Manuel Gómez-Guzmán, Maria José Zarzuelo, Miguel Romero, Manuel Sánchez, Ana María Quintela, Pilar Galindo, Francisco O'Valle, Juan Tamargo, Francisco Pérez-Vizcaíno, Juan Duarte, Rosario Jiménez
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (8): 321–333.
Published: 22 December 2010
... endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O 2 •− (superoxide anion). Our present study was designed to evaluate whether RWPs act directly in the vascular wall improving endothelial dysfunction and O 2 •− production induced by ET-1...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 243–253.
Published: 17 January 2006
...)-salt hypertension endothelin-1 ET A receptor NADPH oxidase oxidative stress Oxidative stress, characterized by increased bioavailability of ROS (reactive oxygen species), plays an important role in the development and progression of cardiovascular dysfunction associated with hypertensive...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...
Articles
Robert A. COX, Perenlei ENKHABAATAR, Ann S. BURKE, Jiro KATAHIRA, Katahiro SHIMODA, Abhijit CHANDRA, Lillian D. TRABER, David N. HERNDON, Hal K. HAWKINS, Daniel L. TRABER
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (3): 265–272.
Published: 18 February 2005
...Robert A. COX; Perenlei ENKHABAATAR; Ann S. BURKE; Jiro KATAHIRA; Katahiro SHIMODA; Abhijit CHANDRA; Lillian D. TRABER; David N. HERNDON; Hal K. HAWKINS; Daniel L. TRABER Studies have suggested that ET-1 (endothelin-1) is associated with lung injury, airway inflammation and increased vascular...
Articles
Roger CORDER, Richard C. WARBURTON, Noorafza Q. KHAN, Ruth E. BROWN, Elizabeth G. WOOD, Delphine M. LEES
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (5): 513–517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
Articles
Torsten SLOWINSKI, Norma SCHULZ, Frank T. RUSCHITZKA, Thomas QUASCHNING, Christian BAUER, Franz THEURING, Hans-H. NEUMAYER, Max GASSMANN, Berthold HOCHER
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 44S–47S.
Published: 01 September 2002
... viscosity and volume. As a consequence, renal tissue endothelin-1 (ET-1) concentrations are significantly elevated in erythropoietin-overexpressing (Epo+) mice (mean±S.E.M; Epo+, 798±71; Epo-, 400±25pg/g tissue; P <0.01). To investigate the pattern of expression of the primary translation product...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 137S–140S.
Published: 01 September 2002
...Bernhard R. BREHM; Martina KLAUSSNER; Sabine C. WOLF Increased endothelin-1 (ET-1) levels are found in patients with atherosclerosis. ET-1 is known to increase the mitotic response of different growth factors already at threshold concentrations. The aim of this study was to investigate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
Published: 01 September 2002
...Sabine C. WOLF; Thorsten AMEND; Teut RISLER; Kerstin AMANN; Bernhard R. BREHM Increased endothelin-1 (ET-1) levels were found in patients with chronic renal failure and these correlate with the severity of renal failure. Increased mortality due to cardiovascular problems is observed in patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 141S–147S.
Published: 01 September 2002
... and the confocal microscopy technique, our present results show that stimulation of endothelin-1 (ET-1) receptors at the sarcolemma membrane induced a dose-dependent sustained increase in basal cytosolic and nuclear calcium levels that was insensitive to the ET A and ET B receptor antagonists BQ123 and BQ788...
Articles
Maria Angeles MARTÍNEZ, Nuria FERNÁNDEZ, Luis MONGE, Angel Luis GARCÍA-VILLALÓN, Elena SANZ, Godofredo DIÉGUEZ
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
Published: 01 September 2002
...Maria Angeles MARTÍNEZ; Nuria FERNÁNDEZ; Luis MONGE; Angel Luis GARCÍA-VILLALÓN; Elena SANZ; Godofredo DIÉGUEZ To examine coronary reactivity to acetylcholine and endothelin-1 (ET-1) during partial ischaemia and reperfusion, flow in the left circumflex coronary artery was measured...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 408S–413S.
Published: 01 September 2002
... (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 big endothelin-1 ET(A) receptor antagonist rat basilar artery LU 208075 ...
Articles
Takehiro OGATA, Takashi MIYAUCHI, Satoshi SAKAI, Yoko IRUKAYAMA-TOMOBE, Katsutoshi GOTO, Iwao YAMAGUCHI
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 284S–288S.
Published: 01 September 2002
...Takehiro OGATA; Takashi MIYAUCHI; Satoshi SAKAI; Yoko IRUKAYAMA-TOMOBE; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) production is increased in hypertrophied hearts accompanied with fibrosis. ET-1 is a potent mitogen of fibroblasts and ET receptor antagonists are reported to inhibit...
Articles
Violetta KÉKESI, Endre ZIMA, Erzsébet BARÁT, Éva HUSZÁR, Andrea NAGY, László LOSONCZI, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
Published: 01 September 2002
... the intrapericardial concentrations of adenosine, inosine and hypoxanthine during coronary spasm provoked by intracoronary administration of endothelin-1 (ET-1; 0.08±0.02nmol/g of myocardial tissue). In the in situ dog heart ( n = 10), adenosine, inosine and hypoxanthine concentrations were determined by HPLC in fluid...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 327S–331S.
Published: 01 September 2002
... gingivalis . Our aims in the present study were to examine the expression of endothelin-1 (ET-1) in cultured HEp-2 epithelial cells after infection with P. gingivalis , and in gingival tissue from adult periodontitis patients. The cell lines were infected with the strains P. gingivalis 33277 and 381...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 289S–293S.
Published: 01 September 2002
...) and endothelin-1 (ET-1) in the rat lung. Nine 42-day-old Wistar rats underwent abdominal aortocaval shunt to increase pulmonary blood flow for 12 weeks. The shunt resulted in significant medial hypertrophy of pulmonary artery without significant alterations in pulmonary or systemic blood pressure. Using...
Articles
Satoshi SAKAI, Takashi MIYAUCHI, Yoko IRUKAYAMA-TOMOBE, Takehiro OGATA, Katsutoshi GOTO, Iwao YAMAGUCHI
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 16S–20S.
Published: 01 September 2002
...Satoshi SAKAI; Takashi MIYAUCHI; Yoko IRUKAYAMA-TOMOBE; Takehiro OGATA; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) causes cardiac hypertrophy, and ET receptor antagonists inhibit the development of cardiac hypertrophy in vitro and in vivo . Peroxisome proliferator-activated receptor γ...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 245S–248S.
Published: 01 September 2002
...Zaid ABASSI; Bahaa FRANCIS; Jerry WESSALE; Elena OVCHARENKO; Joseph WINAVER; Aaron HOFFMAN The present study examined the effects of two highly selective endothelin-1 (ET-1) receptor antagonists, ABT-627 (ET A blocker) and A-192621 (ET B blocker), on the systemic and renal haemodynamic effects...
Articles
Endre ZIMA, Violetta KÉKESI, Andrea NAGY, László LOSONCZI, Ildikó TOMA, Pál SOÓS, Erzsébet Barát, Éva HUSZÁR, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 202S–205S.
Published: 01 September 2002
...Endre ZIMA; Violetta KÉKESI; Andrea NAGY; László LOSONCZI; Ildikó TOMA; Pál SOÓS; Erzsébet Barát; Éva HUSZÁR; Béla MERKELY; Ferenc HORKAY; Alexander Juhász-Nagy Pericardial fluid accumulates the cardioprotective purine metabolites, as well as the endogenous vasoconstrictor agent endothelin-1 (ET-1...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
Articles
Bruno BALSIGER, Andreas RICKENBACHER, Penelope Jane BODEN, Erwin BIECKER, Janice TSUI, Michael DASHWOOD, Jürg REICHEN, Sidney George SHAW
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 430S–433S.
Published: 01 September 2002
... International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr S.G. Shaw (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 receptors nitric oxide diabetes gut glucose tolerance 430S...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 72S–75S.
Published: 01 September 2002
... compounds present in red wine. Here we show that an extract of red wine polyphenols causes a concentration-dependent inhibition of endothelin-1 synthesis in cultured bovine aortic endothelial cells. This action was associated with modifications in phosphotyrosine staining, indicating that the active...
Articles
Jan KAEHLER, Bjoern SILL, Ralf KOESTER, Clemens MITTMANN, Hans-Dieter ORZECHOWSKI, Thomas MUENZEL, Thomas MEINERTZ
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
Published: 01 September 2002
...Jan KAEHLER; Bjoern SILL; Ralf KOESTER; Clemens MITTMANN; Hans-Dieter ORZECHOWSKI; Thomas MUENZEL; Thomas MEINERTZ A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 450S–454S.
Published: 01 September 2002
... angiogenesis. The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr M. Akimoto (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 gastric ulcer angiogenesis endothelin-1 ETA...
Articles
Robert C. CALVERT, Faiz H. MUMTAZ, Mick R. DASHWOOD, Masood A. KHAN, Robert J. MORGAN, Dimitri P. MIKHAILIDIS, Cecil S. THOMPSON
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 459S–463S.
Published: 01 September 2002
...Robert C. CALVERT; Faiz H. MUMTAZ; Mick R. DASHWOOD; Masood A. KHAN; Robert J. MORGAN; Dimitri P. MIKHAILIDIS; Cecil S. THOMPSON Endothelin-1 (ET-1) causes urinary bladder smooth muscle contraction and the endothelin receptors A and B (ET A and ET B ) are both known to be present in the rabbit...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 464S–466S.
Published: 01 September 2002
...Nicoletta BASILICO; Livianna SPECIALE; Silvia PARAPINI; Pasquale FERRANTE; Donatella TARAMELLI In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum -parasitized red blood cells (pRBCs...
Articles
Yasuo MATSUMURA, Junji YAMASHITA, Satomi KITA, Takahiro IWAMOTO, Masaya OGATA, Masanori TAKAOKA, Koji WAKIMOTO, Munekazu SHIGEKAWA, Issei KOMURO
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 389S–392S.
Published: 01 September 2002
...-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 Na+/Ca2+ exchanger endothelin-1 acute renal failure ischaemia reperfusion 389SClinical Science (2002) 103 (Suppl. 48), 389S 392S (Printed in Great Britain) Pathophysiological roles of Ca2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 434S–437S.
Published: 01 September 2002
... by suppression of enhanced endothelin-1 production in postischaemic kidneys. Ischaemic ARF was induced by clamping the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function parameters such as blood urea nitrogen, plasma creatinine and creatinine...
Articles
Seiji MAEDA, Takashi MIYAUCHI, Motoyuki IEMITSU, Takumi TANABE, Tomoko YOKOTA, Katsutoshi GOTO, Iwao YAMAGUCHI, Mitsuo MATSUDA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 118S–123S.
Published: 01 September 2002
...Seiji MAEDA; Takashi MIYAUCHI; Motoyuki IEMITSU; Takumi TANABE; Tomoko YOKOTA; Katsutoshi GOTO; Iwao YAMAGUCHI; Mitsuo MATSUDA Aging impairs endothelial function and the vascular tone regulation, although the precise mechanism remains unclear. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide...
Articles
Tsuyoshi UCHIDE, Yuki FUJIMORI, Takushi SASAKI, Kyosuke TEMMA, Javier ADUR, Yoshinori MASUO, Takaharu KOZAKAI, Yun-Sik LEE, Kaname SAIDA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 167S–170S.
Published: 01 September 2002
...Tsuyoshi UCHIDE; Yuki FUJIMORI; Takushi SASAKI; Kyosuke TEMMA; Javier ADUR; Yoshinori MASUO; Takaharu KOZAKAI; Yun-Sik LEE; Kaname SAIDA In an attempt to understand the significance of endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 peptides in organs during perinatal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 215S–218S.
Published: 01 September 2002
...Martin E. BEYER; Marcus FISCHER; Tobias HÖVELBORN; Hans Martin HOFFMEISTER Endothelin-1 (ET-1) is a potent vasoconstrictor, and ET A receptors mainly mediate this effect. Elevated plasma levels of ET-1 are observed in patients with coronary heart disease. The release of this peptide from...
Articles
Takashi YAMAMOTO, Atsuyuki WADA, Masato OHNISHI, Takayoshi TSUTAMOTO, Masanori FUJII, Takehiro MATSUMOTO, Tomoyuki TAKAYAMA, Xinwen WANG, Kiyoshi KUROKAWA, Masahiko KINOSHITA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 258S–262S.
Published: 01 September 2002
...Takashi YAMAMOTO; Atsuyuki WADA; Masato OHNISHI; Takayoshi TSUTAMOTO; Masanori FUJII; Takehiro MATSUMOTO; Tomoyuki TAKAYAMA; Xinwen WANG; Kiyoshi KUROKAWA; Masahiko KINOSHITA Endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) play important roles in the regulation of body fluid balance...
Articles
Cornelia HAUG, Alexandra SCHMID-KOTSAS, Theresia LINDER, Peter M. JEHLE, Max G. BACHEM, Adolf GRUENERT, Eva ROZDZINSKI
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 76S–80S.
Published: 01 September 2002
...Cornelia HAUG; Alexandra SCHMID-KOTSAS; Theresia LINDER; Peter M. JEHLE; Max G. BACHEM; Adolf GRUENERT; Eva ROZDZINSKI Several studies have demonstrated that endothelin-1 (ET-1) plays an important pathophysiological role in ischaemic renal failure and drug-induced renal injury, such as cyclosporine...
Articles
Torsten SLOWINSKI, Thomas SUBKOWSKI, Petra DIEHR, Daniela BACHERT, Lutz FRITSCHE, Hans.-H. NEUMAYER, Berthold HOCHER
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 393S–395S.
Published: 01 September 2002
... dysfunction endothelin-1 endothelin-converting enzyme kidney transplantation 393SClinical Science (2002) 103 (Suppl. 48), 393S 395S (Printed in Great Britain) Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction Torsten...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 124S–127S.
Published: 01 September 2002
...Katherine E. WILEY; Anthony P. DAVENPORT The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro. Cumulative concentration–response curves to ET-1 were constructed in rings of IMA and the data...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 171S–175S.
Published: 01 September 2002
.... The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A. P. Davenport (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 apelin atherosclerosis coronary artery endothelin-1...
Articles
Kazuhiro TAKAHASHI, Kazuhito TOTSUNE, Tomomi KITAMURO, Masahiko SONE, Osamu MURAKAMI, Shigeki SHIBAHARA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 35S–38S.
Published: 01 September 2002
...Kazuhiro TAKAHASHI; Kazuhito TOTSUNE; Tomomi KITAMURO; Masahiko SONE; Osamu MURAKAMI; Shigeki SHIBAHARA Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study...
Articles
Huan HUANG, Masashi YANAGISAWA, Yaz Y. KISANUKI, Linda A. JELICKS, Madhulika CHANDRA, Stephen M. FACTOR, Murray WITTNER, Louis M. WEISS, Richard G. PESTELL, Vitaliy SHTUTIN, Jamshid SHIRANI, Herbert B. TANOWITZ
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 263S–266S.
Published: 01 September 2002
... of chronic cardiomyopathy. We previously demonstrated a role for endothelin-1 (ET-1) in the pathogenesis of chagasic heart disease. In order to explore further the significance of ET-1 in chagasic heart disease, we infected ET-1 (flox/flox); α-MHC-Cre(+) (ET-1KO) mice, in which the ET-1 gene has been deleted...
Articles
Abdelmejid KANDOUSSI, François MARTIN, Marc HAZZAN, Christian NOËL, Jean-Charles FRUCHART, Bart STAELS, Patrick DURIEZ
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 81S–83S.
Published: 01 September 2002
... The Biochemical Society and the Medical Research Society 2002 endothelin-1 cyclosporin A PPAR-alpha activators ciprofibric acid HMG-CoA inhibitors compactin 81SClinical Science (2002) 103 (Suppl. 48), 81S 83S (Printed in Great Britain) HMG-CoA reductase inhibition and PPAR- alpha activation both...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (5): 547–552.
Published: 18 April 2002
... (NO) and endothelin-1 (ET-1) levels, and endothelium-dependent and -independent vasodilation in normal males. Plasma ET-1 and NO were measured every 4h in nine subjects (20-41 years old) over a 24h period. Endothelium-dependent and -independent vascular responses were measured in the forearm skin every 4h using laser...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (6): 731–738.
Published: 21 November 2001
...M.R. LANGENFELD; S. NAKHLA; A.K. DEATH; W. JESSUP; D.S. CELERMAJER Endothelin-1 is a potent vasoconstrictor and mitogenic peptide that is implicated in the atherosclerosis of apolipoprotein E-deficient mice and may promote atherogenesis in humans. We hypothesized that endothelin-1 might promote...
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