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Keywords: Endothelin-1
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Articles
Clin Sci (Lond) (2024) 138 (23): 1505–1520.
Published: 26 November 2024
... for poor vascular health and vascular dysfunction. High levels of vascular reactive oxygen species (ROS) as well as elevated plasma endothelin-1 (ET-1), a potent vasoconstrictor with actions via the ET A receptor, are both common phenotypes in SCD. Alpha-1 adrenergic receptor activation is a major mediator...
Includes: Supplementary data
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Clin Sci (Lond) (2024) 138 (21): 1329–1341.
Published: 24 October 2024
...Eda Karakaya; Yasir Abdul; Jazlyn Edwards; Sarah Jamil; Onder Albayram; Adviye Ergul Endothelin-1 (ET-1), the most potent vasoconstrictor identified to date, contributes to cerebrovascular dysfunction. ET-1 levels in postmortem brain specimens from individuals diagnosed with Alzheimer’s disease (AD...
Includes: Supplementary data
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Clin Sci (Lond) (2024) 138 (16): 1009–1022.
Published: 21 August 2024
... ]. Additionally, pericytes have been identified to become inflammatory and undergo a microglial transition after ischemic stroke, which is a common risk factor for VCID [ 36 ]. However, this concept has not been investigated in diabetic conditions. Endothelin-1 (ET-1) is the most potent vasoconstrictor...
Includes: Supplementary data
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Clin Sci (Lond) (2024) 138 (11): 645–662.
Published: 29 May 2024
... well established. The few known physiologic actions, including natriuresis/diuresis and vasodilation, have been summarized previously by Bader and colleagues [ 18 ]. Angiotensin II Endothelin Type A receptor Endothelin-1 FSGS IgA nephropathy Sparsentan Travere Therapeutics, Inc...
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Clin Sci (Lond) (2019) 133 (13): 1475–1486.
Published: 15 July 2019
... ). Previous studies have demonstrated that endothelin-1 (ET-1) contributes to P alb changes in models of diabetes and SCD. Thus, we performed longitudinal studies of renal function to determine the relationship between ET-1 and glomerular size and P alb that may contribute to hyperfiltration in humanized...
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Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1 fl/fl control mice. Endothelin-1 (EDN1) and phospho-Jun-amino-terminal kinase (p-JNK) were up-regulated in Fibro-TSC1 −/− renal fibroblasts after LPS challenge. Rapamycin, an mTORC1 inhibitor, and bosentan, an EDN1 antagonist...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (23): 2777–2789.
Published: 23 November 2017
... vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ET B R). We evaluated ET-1 sensitivity, ET A R, and ET B R contributions to ET-1-mediated constriction, and the mechanistic role of ET B R in endothelium-dependent dilation in vivo in the microvasculature...
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Clin Sci (Lond) (2016) 130 (1): 19–33.
Published: 30 November 2015
... development and extracellular-signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation in aortic rings from KO animals. By contrast, we observed no difference in force development during application of serotonin, KCl, endothelin-1 or endothelin-1-induced pressure load in KO animals. In addition, nitric oxide...
Includes: Supplementary data
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Clin Sci (Lond) (2006) 110 (2): 243–253.
Published: 17 January 2006
...)-salt hypertension endothelin-1 ET A receptor NADPH oxidase oxidative stress Oxidative stress, characterized by increased bioavailability of ROS (reactive oxygen species), plays an important role in the development and progression of cardiovascular dysfunction associated with hypertensive...
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Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...
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Clin Sci (Lond) (2004) 107 (5): 513–517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
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Clin Sci (Lond) (2002) 103 (s2002): 137S–140S.
Published: 01 September 2002
...Bernhard R. BREHM; Martina KLAUSSNER; Sabine C. WOLF Increased endothelin-1 (ET-1) levels are found in patients with atherosclerosis. ET-1 is known to increase the mitotic response of different growth factors already at threshold concentrations. The aim of this study was to investigate...
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Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
Published: 01 September 2002
...Sabine C. WOLF; Thorsten AMEND; Teut RISLER; Kerstin AMANN; Bernhard R. BREHM Increased endothelin-1 (ET-1) levels were found in patients with chronic renal failure and these correlate with the severity of renal failure. Increased mortality due to cardiovascular problems is observed in patients...
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Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
Published: 01 September 2002
... the intrapericardial concentrations of adenosine, inosine and hypoxanthine during coronary spasm provoked by intracoronary administration of endothelin-1 (ET-1; 0.08±0.02nmol/g of myocardial tissue). In the in situ dog heart ( n = 10), adenosine, inosine and hypoxanthine concentrations were determined by HPLC in fluid...
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Clin Sci (Lond) (2002) 103 (s2002): 327S–331S.
Published: 01 September 2002
... gingivalis . Our aims in the present study were to examine the expression of endothelin-1 (ET-1) in cultured HEp-2 epithelial cells after infection with P. gingivalis , and in gingival tissue from adult periodontitis patients. The cell lines were infected with the strains P. gingivalis 33277 and 381...
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Clin Sci (Lond) (2002) 103 (s2002): 289S–293S.
Published: 01 September 2002
...) and endothelin-1 (ET-1) in the rat lung. Nine 42-day-old Wistar rats underwent abdominal aortocaval shunt to increase pulmonary blood flow for 12 weeks. The shunt resulted in significant medial hypertrophy of pulmonary artery without significant alterations in pulmonary or systemic blood pressure. Using...
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Clin Sci (Lond) (2002) 103 (s2002): 16S–20S.
Published: 01 September 2002
...Satoshi SAKAI; Takashi MIYAUCHI; Yoko IRUKAYAMA-TOMOBE; Takehiro OGATA; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) causes cardiac hypertrophy, and ET receptor antagonists inhibit the development of cardiac hypertrophy in vitro and in vivo . Peroxisome proliferator-activated receptor γ...
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Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
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Clin Sci (Lond) (2002) 103 (s2002): 72S–75S.
Published: 01 September 2002
... compounds present in red wine. Here we show that an extract of red wine polyphenols causes a concentration-dependent inhibition of endothelin-1 synthesis in cultured bovine aortic endothelial cells. This action was associated with modifications in phosphotyrosine staining, indicating that the active...
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Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
Published: 01 September 2002
...Jan KAEHLER; Bjoern SILL; Ralf KOESTER; Clemens MITTMANN; Hans-Dieter ORZECHOWSKI; Thomas MUENZEL; Thomas MEINERTZ A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development...
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Clin Sci (Lond) (2002) 103 (s2002): 450S–454S.
Published: 01 September 2002
... angiogenesis. The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr M. Akimoto (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 gastric ulcer angiogenesis endothelin-1 ETA...
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Clin Sci (Lond) (2002) 103 (s2002): 459S–463S.
Published: 01 September 2002
...Robert C. CALVERT; Faiz H. MUMTAZ; Mick R. DASHWOOD; Masood A. KHAN; Robert J. MORGAN; Dimitri P. MIKHAILIDIS; Cecil S. THOMPSON Endothelin-1 (ET-1) causes urinary bladder smooth muscle contraction and the endothelin receptors A and B (ET A and ET B ) are both known to be present in the rabbit...
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Clin Sci (Lond) (2002) 103 (s2002): 464S–466S.
Published: 01 September 2002
...Nicoletta BASILICO; Livianna SPECIALE; Silvia PARAPINI; Pasquale FERRANTE; Donatella TARAMELLI In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum -parasitized red blood cells (pRBCs...
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Clin Sci (Lond) (2002) 103 (s2002): 434S–437S.
Published: 01 September 2002
... by suppression of enhanced endothelin-1 production in postischaemic kidneys. Ischaemic ARF was induced by clamping the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function parameters such as blood urea nitrogen, plasma creatinine and creatinine...
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Clin Sci (Lond) (2002) 103 (s2002): 118S–123S.
Published: 01 September 2002
...Seiji MAEDA; Takashi MIYAUCHI; Motoyuki IEMITSU; Takumi TANABE; Tomoko YOKOTA; Katsutoshi GOTO; Iwao YAMAGUCHI; Mitsuo MATSUDA Aging impairs endothelial function and the vascular tone regulation, although the precise mechanism remains unclear. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide...
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Clin Sci (Lond) (2002) 103 (s2002): 167S–170S.
Published: 01 September 2002
...Tsuyoshi UCHIDE; Yuki FUJIMORI; Takushi SASAKI; Kyosuke TEMMA; Javier ADUR; Yoshinori MASUO; Takaharu KOZAKAI; Yun-Sik LEE; Kaname SAIDA In an attempt to understand the significance of endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 peptides in organs during perinatal...
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Clin Sci (Lond) (2002) 103 (s2002): 215S–218S.
Published: 01 September 2002
...Martin E. BEYER; Marcus FISCHER; Tobias HÖVELBORN; Hans Martin HOFFMEISTER Endothelin-1 (ET-1) is a potent vasoconstrictor, and ET A receptors mainly mediate this effect. Elevated plasma levels of ET-1 are observed in patients with coronary heart disease. The release of this peptide from...
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Clin Sci (Lond) (2002) 103 (s2002): 76S–80S.
Published: 01 September 2002
...Cornelia HAUG; Alexandra SCHMID-KOTSAS; Theresia LINDER; Peter M. JEHLE; Max G. BACHEM; Adolf GRUENERT; Eva ROZDZINSKI Several studies have demonstrated that endothelin-1 (ET-1) plays an important pathophysiological role in ischaemic renal failure and drug-induced renal injury, such as cyclosporine...
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Clin Sci (Lond) (2002) 103 (s2002): 124S–127S.
Published: 01 September 2002
...Katherine E. WILEY; Anthony P. DAVENPORT The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro. Cumulative concentration–response curves to ET-1 were constructed in rings of IMA and the data...
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Clin Sci (Lond) (2002) 103 (s2002): 263S–266S.
Published: 01 September 2002
... of chronic cardiomyopathy. We previously demonstrated a role for endothelin-1 (ET-1) in the pathogenesis of chagasic heart disease. In order to explore further the significance of ET-1 in chagasic heart disease, we infected ET-1 (flox/flox); α-MHC-Cre(+) (ET-1KO) mice, in which the ET-1 gene has been deleted...
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Clin Sci (Lond) (2002) 102 (5): 547–552.
Published: 18 April 2002
... (NO) and endothelin-1 (ET-1) levels, and endothelium-dependent and -independent vasodilation in normal males. Plasma ET-1 and NO were measured every 4h in nine subjects (20-41 years old) over a 24h period. Endothelium-dependent and -independent vascular responses were measured in the forearm skin every 4h using laser...
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Clin Sci (Lond) (2001) 101 (6): 731–738.
Published: 21 November 2001
...M.R. LANGENFELD; S. NAKHLA; A.K. DEATH; W. JESSUP; D.S. CELERMAJER Endothelin-1 is a potent vasoconstrictor and mitogenic peptide that is implicated in the atherosclerosis of apolipoprotein E-deficient mice and may promote atherogenesis in humans. We hypothesized that endothelin-1 might promote...