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Keywords: Endothelin-1
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Clin Sci (Lond) (2024) 138 (11): 645–662.
Published: 29 May 2024
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Endothelin-1 (ET-1) is a potent peptide that activates multiple signaling pathways and is strongly implicated in renal...
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Clin Sci (Lond) (2019) 133 (13): 1475–1486.
Published: 15 July 2019
... ). Previous studies have demonstrated that endothelin-1 (ET-1) contributes to P alb changes in models of diabetes and SCD. Thus, we performed longitudinal studies of renal function to determine the relationship between ET-1 and glomerular size and P alb that may contribute to hyperfiltration in humanized...
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Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1 fl/fl control mice. Endothelin-1 (EDN1) and phospho-Jun-amino-terminal kinase (p-JNK) were up-regulated in Fibro-TSC1 −/− renal fibroblasts after LPS challenge. Rapamycin, an mTORC1 inhibitor, and bosentan, an EDN1 antagonist...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (23): 2777–2789.
Published: 23 November 2017
... vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ET B R). We evaluated ET-1 sensitivity, ET A R, and ET B R contributions to ET-1-mediated constriction, and the mechanistic role of ET B R in endothelium-dependent dilation in vivo in the microvasculature...
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Clin Sci (Lond) (2016) 130 (1): 19–33.
Published: 30 November 2015
... development and extracellular-signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation in aortic rings from KO animals. By contrast, we observed no difference in force development during application of serotonin, KCl, endothelin-1 or endothelin-1-induced pressure load in KO animals. In addition, nitric oxide...
Includes: Supplementary data
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Clin Sci (Lond) (2004) 107 (5): 513–517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
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Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
Published: 01 September 2002
...Sabine C. WOLF; Thorsten AMEND; Teut RISLER; Kerstin AMANN; Bernhard R. BREHM Increased endothelin-1 (ET-1) levels were found in patients with chronic renal failure and these correlate with the severity of renal failure. Increased mortality due to cardiovascular problems is observed in patients...
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Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
Published: 01 September 2002
... the intrapericardial concentrations of adenosine, inosine and hypoxanthine during coronary spasm provoked by intracoronary administration of endothelin-1 (ET-1; 0.08±0.02nmol/g of myocardial tissue). In the in situ dog heart ( n = 10), adenosine, inosine and hypoxanthine concentrations were determined by HPLC in fluid...
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Clin Sci (Lond) (2002) 103 (s2002): 430S–433S.
Published: 01 September 2002
.... Endothelin-1 (ET-1) and NO represent key homoeostatic mechanisms reciprocally involved in several disease processes, including the regulation of vascular tone, neurotransmission and endoneural and retinal blood flow. Effects are mediated in an autocrine Key words : endothelin-1, receptors, nitric oxide...
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Clin Sci (Lond) (2002) 103 (s2002): 215S–218S.
Published: 01 September 2002
...Martin E. BEYER; Marcus FISCHER; Tobias HÖVELBORN; Hans Martin HOFFMEISTER Endothelin-1 (ET-1) is a potent vasoconstrictor, and ET A receptors mainly mediate this effect. Elevated plasma levels of ET-1 are observed in patients with coronary heart disease. The release of this peptide from...
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Clin Sci (Lond) (2002) 103 (s2002): 393S–395S.
Published: 01 September 2002
... of impaired kidney function. However, the actual concentration of ET-1, soluble ECE, and BigET-1 in urine and plasma in our study is not associated with parameters for progression of chronic graft dysfunction. chronic graft dysfunction endothelin-1 endothelin-converting enzyme kidney transplantation...
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Clin Sci (Lond) (2002) 102 (5): 547–552.
Published: 18 April 2002
... (NO) and endothelin-1 (ET-1) levels, and endothelium-dependent and -independent vasodilation in normal males. Plasma ET-1 and NO were measured every 4h in nine subjects (20-41 years old) over a 24h period. Endothelium-dependent and -independent vascular responses were measured in the forearm skin every 4h using laser...
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Clin Sci (Lond) (2001) 100 (1): 19–23.
Published: 05 December 2000
...A. J. BROWN; J. E. NALLY Angiotensin II potentiates methacholine-evoked bronchoconstriction both in bovine airways in vitro and in asthmatic patients in vivo . Angiotensin II also potentiates endothelin-1-evoked contractions in vitro , but fails to alter such contractions in vivo . One possible...
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Clin Sci (Lond) (2000) 98 (1): 65–70.
Published: 22 November 1999
... understanding of the venoconstrictor actions of endothelin-1 in this disease. Two main subtypes of endothelin receptor, ET A and ET B , exist in human blood vessels. We studied the venoconstrictor effects of endothelin-1 (a non-selective ET A and ET B agonist) and sarafotoxin S6c (a selective ET B agonist...
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Clin Sci (Lond) (1999) 97 (6): 671–679.
Published: 15 November 1999
... hormones were also measured. There were no morphological differences between small arteries from control subjects and those from patients with chronic heart failure. In heart failure patients, vasoconstrictor responses to endothelin-1 were significantly reduced, although plasma endothelin-1 levels were...
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Clin Sci (Lond) (1998) 95 (2): 151–156.
Published: 01 August 1998
... endothelin-1 is increased in chronic heart failure, endothelin-1 may act in an autocrine manner to modulate these effects. 2. To test this, we determined whether prolonged endothelin infusion in normal subjects would reproduce the alterations in basal and stimulated nitric oxide release observed in patients...