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Keywords: Epigenetics
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Clin Sci (Lond) (2024) 138 (5): 251–268.
Published: 27 February 2024
... 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 Epigenetics EZH2 inhibitor MMP2 vascular smooth muscle Vascular Stiffness American Heart Association (AHA) 100000968 903910 National Heart, Lung, and Blood Institute (NHLBI...
Includes: Supplementary data
Clin Sci (Lond) (2023) 137 (3): 265–279.
Published: 10 February 2023
.... The validated DMCs were strongly enriched in active placenta-specific enhancers and showed highly dynamic methylation levels. We found high epigenetic heterogeneity between vDMCs and adjacent CpG sites ( r 2 < 0.2) and a significant decrease in PE in the discovery and replication cohorts ( P = 2.00 × 10 −24...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (10): 1289–1293.
Published: 28 May 2021
... efforts are underway to decipher the complex PDAC TME, break down barriers to efficacious therapies and identify novel treatment strategies. In the recent Clinical Science, Li and colleagues identify the long noncoding RNA KLHDC7B-DT as a crucial epigenetic regulator of IL-6 transcription in PDAC...
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
...-related cell-specific transcriptomic profiles but also novel subpopulations of cells once thought as homogenous cell populations. Vascular cells undergo specific transcriptional changes during the entire course of the disease. Epigenetics is the instruction-set-architecture in living cells that defines...
Clin Sci (Lond) (2021) 135 (1): 127–142.
Published: 08 January 2021
... in disease susceptibility among individuals exposed to the same environmental insult or who acquire the same genetic variation. Epigenetics is the intertwining of genetic and environmental factors that results in diversity in the disease course, severity, and prognosis among individuals. Environmental...
Clin Sci (Lond) (2020) 134 (23): 3079–3091.
Published: 02 December 2020
... of AML1-ETO + leukemia cells in vitro . Enhanced miR564 levels can significantly inhibit the tumor proliferation of t(8;21)AML in vivo . We first identify an unexpected and important epigenetic circuitry of AML1-ETO/ miR564/CCND1/DNMT3A that contributes to the leukemogenesis in vitro/vivo of AML1-ETO...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (9): 1049–1052.
Published: 07 May 2019
... of the complexity of gene regulation and in the case of Zhang and colleagues add the new layer of epigenetic mechanism. Moreover, they also highlight the possibility that manipulation of miRNAs by circRNAs in SLE treatment may hold antiautoimmune potential. Future use could be made in SLE patient treatment...
Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
... vascular disease and death. Although a wide spectrum of causative factors has been identified and/or suggested, there is still a large gap of knowledge regarding the underlying mechanisms and the complexity of the CKD phenotype. Epigenetic factors, which calibrate the genetic code, are emerging...
Clin Sci (Lond) (2016) 130 (16): 1389–1405.
Published: 07 July 2016
...Amalia Forte; Umberto Galderisi; Marilena Cipollaro; Marisa De Feo; Alessandro Della Corte The term ‘epigenetics’ refers to heritable, reversible DNA or histone modifications that affect gene expression without modifying the DNA sequence. Epigenetic modulation of gene expression also includes...
Clin Sci (Lond) (2016) 130 (13): 1051–1063.
Published: 23 May 2016
... for muscle metabolic processes. Substantial evidence is emerging that highlights the importance of epigenetic mechanisms in this process. This review will examine the importance of epigenetics in the regulation of muscle metabolism, with a particular emphasis on DNA methylation and histone acetylation...
Clin Sci (Lond) (2016) 130 (12): 943–986.
Published: 06 May 2016
... between genetic susceptibility, epigenetics, metagenomics and the environment. Attempts at understanding the genetic basis of obesity have identified numerous genes associated with syndromic monogenic, non-syndromic monogenic, oligogenic and polygenic obesity. The genetics of leanness are also considered...
Clin Sci (Lond) (2015) 128 (9): 537–558.
Published: 27 January 2015
...Smriti Murali Krishna; Alexandra Fay Trollope; Jonathan Golledge Athero-thrombosis of the arteries supplying the brain and lower limb are the main causes of stroke and limb loss. New therapies are needed to improve the outcomes of athero-thrombosis. Recent evidence suggests a role for epigenetic...
Clin Sci (Lond) (2014) 126 (2): 123–138.
Published: 13 September 2013
... in endometriotic lesions are associated with genetic and epigenetic alterations, including imbalance of miRNA expression, histone and DNA modifications and chromosomal aberrations. The present short review mainly summarizes the latest observations contributing to the current knowledge regarding the presence...