... response. Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome’s microRNAs due to their capacity to fine-tune gene expression, potentially affecting the multicellular repair response. We profiled...

... was enabled by the participation of Liverpool John Moores University in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. circadian clock exosomes keratinocytes microRNA skin wound healing Chronic, non...

...Wenjuan Yu; Honghui Zeng; Junzhe Chen; Sha Fu; Qiuyan Huang; Yanchun Xu; Anping Xu; Hui-yao Lan; Ying Tang Exosomes have been shown to effectively regulate the biological functions of target cells. Here, we investigated the protective effect and mechanism of hypoxia-induced renal tubular epithelial...

... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer-associated fibroblasts Exosomes JAK2/STAT3 pathway lung cancer miR-210 The authors of the original article “miR- 210 transferred by lung cancer cell-derived exosomes may act...

...Francesco Mannavola; Gaetano Pezzicoli; Marco Tucci Exosomes (Exo) have emerged as potent amplifiers of pro-tumorigenic signals to distant cells. The knowledge of their role in colorectal cancer (CRC) is continuously up-growing, although their contribution to metastasis remains largely unclear. Liu...

...Junqiang Fan; Guanxin Xu; Zhibo Chang; Ling Zhu; Jie Yao It has been generally believed that cancer-associated fibroblasts (CAFs) have the ability to increase the process of tumor angiogenesis. However, the potential mechanisms by which cancer-derived exosomes in lung cancer (LC) remains...

... Limited on behalf of the Biochemical Society 2020 exosomes hypoxia placenta preeclampsia Optimal pregnancy outcome is dependent upon successful fertilization, endometrial implantation, and placentation to support blastocyst development [ 1 ]. Extravillous trophoblast plays a significant...

... targets. Correspondence: Jason E. Fish ( Jason.Fish@utoronto.ca ) or Kathryn L. Howe ( Kathryn.Howe@uhn.ca ) 18 10 2019 12 12 2019 03 01 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 stroke carotid exosomes...

...Shuming Wang; Yilin Hu; Xiurui Lv; Bin Li; Dianhua Gu; Yang Li; Yong Sun; Yang Su Circular RNAs (circRNAs) play a vital role in cancers. Accumulated evidences showed that the physiological condition of cells can be reflected by the circRNAs in the exosomes they secrete, and these exosomal circRNAs...

...Hui Hu; Boshi Wang; Chunyu Jiang; Ruiting Li; Jungong Zhao Background: Our previous studies observed that administration of exosomes from endothelial progenitor cells (EPC) facilitated vascular repair in the rat model of balloon injury. However, the molecular events underlying this process remain...

...Mona Alharbi; Andrew Lai; Dominic Guanzon; Carlos Palma; Felipe Zuñiga; Lewis Perrin; Yaowu He; John D. Hooper; Carlos Salomon Exosomes are small nanovesicles that carry bioactive molecules which can be delivered to neighbouring cells to modify their biological functions. Studies have showed...

..., by highlighting the role of miRNAs in adipose tissue and their eventual involvement in human obesity. adipocytes exosomes MicroRNA metabolism non-coding RNAs Obesity is a worldwide epidemic that arises as a chronic long-term imbalance between calorie intake and energy expenditure. Despite...

..., which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared with normal pregnancies, pregnancies with gestational diabetes mellitus (GDM) are associated with skeletal muscle insulin resistance as well as increased levels of circulating placental...

... attributed to cellular changes in the microenvironment, including increased migration of mesenchymal stem cells (MSCs) and endothelial cells (ECs) to facilitate metastasis. Recently, the ability of exosomes to communicate signals between cells (and promote cancer progression) has been established...

... cellular organelles ER exosomes microparticles mitochondria Cellular organelles have their own critical functions. For example, mitochondria are a power source to maintain cellular and tissue energy demand. However, recent expansion of pharmacological, molecular and genetic tools have allowed us...