... BY) . Extracellular matrix Fibroid Lentivirus MIAT Xenografts The focus of our laboratory has been to identify the mechanisms underlying the dysregulation of protein-coding genes in uterine fibroids, a benign gynecologic tumor affecting up to 80% of reproductive-age women, and the most common indication...

...Natasha Kolesnikoff; Chun-Hsien Chen; Michael Susithiran Samuel Solid tumours are composed of cancer cells characterised by genetic mutations that underpin the disease, but also contain a suite of genetically normal cells and the extracellular matrix (ECM). These two latter components...

...Valter Lubrano; Silvana Balzan Atherosclerosis is a systemic inflammation of the arteries characterized by atherosclerotic plaque due to the accumulation of lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins. Stable plaques present a chronic inflammatory...

... 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Angiogenesis Extracellular matrix Fetal growth restriction Human placenta Placenta stroma Fetal growth restriction (FGR), which occurs when a fetus is unable to meet his or her inherent...

...Kaj E.C. Blokland; Simon D. Pouwels; Michael Schuliga; Darryl A. Knight; Janette K. Burgess The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells providing structural support and stability to tissues. The understanding of the ECM and the diverse roles it plays...

...Yoshito Yamashiro; Hiromi Yanagisawa Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel wall and coordinates with a dynamic mechanical environment to provide...

... by Portland Press Limited on behalf of the Biochemical Society 2019 Extracellular Matrix Sodium Tonicity I read with great interest the hypothesis paper by Rossitto et al [ 1 ]. The authors should be commended for a thoughtful analysis of the interpretation of changes in tissue [Na...

... potential of ADAM8. Current knowledge of substrates and interaction partners gave rise to the hypothesis that ADAM8 dysregulation affects diverse processes in tumor biology, attributable to different functional cores of the multidomain enzyme. Proteolytic degradation of extracellular matrix (ECM) components...

..., thereby facilitating extracellular matrix (ECM) stabilization. Correspondence: Paola Dongiovanni ( [email protected] ) or Luca Valenti ( [email protected] ) * These authors contributed equally to this work. 26 02 2017 10 04 2017 02 05 2017 02 05...

... wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family important in the control of extracellular matrix (ECM) remodelling. In the present study, the association of serum TSP-1 concentration with AAA progression was assessed in 276 men that underwent repeated...

... on possible disease mechanisms in SVD. Proteomic and biochemical studies in post-mortem monogenic SVD patients, as well as in animal models of monogenic disease have suggested that disease pathways are shared between different types of monogenic disease, often involving the impairment of extracellular matrix...

... factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension. The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix (ECM). Elasticity is lost in fibrotic cerebral vessels, reducing...

... with the extracellular matrix (ECM), which are mediated by anchoring filaments (AFs). The ECM protein EMILIN1 is a component of AFs and is involved in the regulation of lymphatic vessel functions: accordingly, Emilin1 −/− mice display lymphatic vascular morphological alterations, leading to functional defects...

... with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional alterations of cells involved...

... called ‘synthetic’, phenotype. Synthetic VSMCs are able to proliferate, migrate and secrete ECM (extracellular matrix) proteinases and ECM proteins. In addition, they produce pro-inflammatory molecules, providing an inflammatory microenvironment for leucocyte penetration, accumulation and activation...

... © 2014 Biochemical Society 2014 angiotensin II (AngII) autoinduction cardiac hypertrophy extracellular matrix signalling transforming growth factor-β (TGF- β) • Excessive activation of the AngII/TGF-β axis is thought to play a central role in the transition from...

... on the development of atherosclerosis; and (iv) the role of FXIIIa on matrix deposition and tissue repair, including cross-linking of extracellular matrix proteins, such as fibronectin, collagen and von Willebrand factor, and the effects on matrix deposition and cell–matrix interactions. The review highlights...

...). An imbalance of extracellular matrix production/degradation was thus observed in veins as well as in the skin of the patients with varicose veins and, taken together, these findings show that remodelling is present in different organs, confirming systemic alterations of connective tissues. Correspondence...

... aortic aneurysm cytokine extracellular matrix integrin metalloproteinase Clinical Science (2004) 106, 301 306 (Printed in Great Britain) 301 Expression and localization of tumour necrosis factor- and its converting enzyme in human abdominal aortic aneurysm Hidetoshi SATOH , Motoyuki NAKAMURA...

... receptors); (iv) factors which regulate detachment from the extracellular matrix (e.g. urokinase-type plasminogen activator, matrix metalloproteinases); and (iv) molecules which regulate cytoskeletal function (e.g. Rac), which allows the formation of specialized cellular processes termed lamellipodia. 3...

... a future therapeutic strategy aimed at transplanting genetically modified oligodendrocyte precursors to repair widespread demyelinated lesions. demyelination extracellular matrix integrin migration multiple sclerosis oligodendrocyte oligodendrocyte precursor remyelination transplantation...

... were suppressed by treatment with methylprednisolone. 8. These data suggest that abnormal regulation of the genes for metalloproteinases and tissue inhibitor of metalloproteinases contribute to the accumulation of extracellular matrix components in lupus nephritis and that the beneficial effect...