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Keywords: Extracellular matrix
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Clin Sci (Lond) (2024) 138 (12): 699–709.
Published: 07 June 2024
... Attribution License 4.0 (CC BY) . Extracellular matrix Fibroid Lentivirus MIAT Xenografts NICHD HD100529, HD100529-02S1, HD101852 and HD109286 The focus of our laboratory has been to identify the mechanisms underlying the dysregulation of protein-coding genes in uterine fibroids...
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Clin Sci (Lond) (2021) 135 (16): 1981–1997.
Published: 20 August 2021
...Valter Lubrano; Silvana Balzan Atherosclerosis is a systemic inflammation of the arteries characterized by atherosclerotic plaque due to the accumulation of lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins. Stable plaques present a chronic inflammatory...
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Clin Sci (Lond) (2020) 134 (17): 2399–2418.
Published: 16 September 2020
...Yoshito Yamashiro; Hiromi Yanagisawa Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel wall and coordinates with a dynamic mechanical environment to provide...
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Clin Sci (Lond) (2019) 133 (6): 739–740.
Published: 19 March 2019
... broadly defined ‘excess’ Na + as the increase in tissue Na + content, usually with an increase in dietary Na + , that is not accounted for by an isonatric gain of fluid (assuming a fixed plasma [Na + ] for simplicity): Extracellular Matrix Sodium Tonicity © 2019 The Author(s). Published...
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Clin Sci (Lond) (2019) 133 (1): 83–99.
Published: 11 January 2019
... potential of ADAM8. Current knowledge of substrates and interaction partners gave rise to the hypothesis that ADAM8 dysregulation affects diverse processes in tumor biology, attributable to different functional cores of the multidomain enzyme. Proteolytic degradation of extracellular matrix (ECM) components...
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Clin Sci (Lond) (2017) 131 (7): 515–531.
Published: 17 March 2017
... on possible disease mechanisms in SVD. Proteomic and biochemical studies in post-mortem monogenic SVD patients, as well as in animal models of monogenic disease have suggested that disease pathways are shared between different types of monogenic disease, often involving the impairment of extracellular matrix...
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Clin Sci (Lond) (2017) 131 (6): 425–437.
Published: 06 March 2017
... factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension. The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix (ECM). Elasticity is lost in fibrotic cerebral vessels, reducing...
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Clin Sci (Lond) (2016) 130 (14): 1221–1236.
Published: 01 June 2016
... with the extracellular matrix (ECM), which are mediated by anchoring filaments (AFs). The ECM protein EMILIN1 is a component of AFs and is involved in the regulation of lymphatic vessel functions: accordingly, Emilin1 −/− mice display lymphatic vascular morphological alterations, leading to functional defects...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (12): 1107–1113.
Published: 22 October 2015
... with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional alterations of cells involved...
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Clin Sci (Lond) (2015) 129 (12): 1077–1081.
Published: 13 October 2015
... called ‘synthetic’, phenotype. Synthetic VSMCs are able to proliferate, migrate and secrete ECM (extracellular matrix) proteinases and ECM proteins. In addition, they produce pro-inflammatory molecules, providing an inflammatory microenvironment for leucocyte penetration, accumulation and activation...
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Clin Sci (Lond) (2014) 126 (4): 275–288.
Published: 14 October 2013
... statistically significant. angiotensin II (AngII) autoinduction cardiac hypertrophy extracellular matrix signalling transforming growth factor-β (TGF- β) • Excessive activation of the AngII/TGF-β axis is thought to play a central role in the transition from compensatory responses...
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Clin Sci (Lond) (2013) 124 (3): 123–137.
Published: 02 October 2012
... on the development of atherosclerosis; and (iv) the role of FXIIIa on matrix deposition and tissue repair, including cross-linking of extracellular matrix proteins, such as fibronectin, collagen and von Willebrand factor, and the effects on matrix deposition and cell–matrix interactions. The review highlights...
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Clin Sci (Lond) (1997) 93 (2): 97–108.
Published: 01 August 1997
... receptors); (iv) factors which regulate detachment from the extracellular matrix (e.g. urokinase-type plasminogen activator, matrix metalloproteinases); and (iv) molecules which regulate cytoskeletal function (e.g. Rac), which allows the formation of specialized cellular processes termed lamellipodia. 3...
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Clin Sci (Lond) (1997) 92 (2): 113–122.
Published: 01 February 1997
... a future therapeutic strategy aimed at transplanting genetically modified oligodendrocyte precursors to repair widespread demyelinated lesions. demyelination extracellular matrix integrin migration multiple sclerosis oligodendrocyte oligodendrocyte precursor remyelination transplantation...
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Clin Sci (Lond) (1993) 85 (3): 295–301.
Published: 01 September 1993
... were suppressed by treatment with methylprednisolone. 8. These data suggest that abnormal regulation of the genes for metalloproteinases and tissue inhibitor of metalloproteinases contribute to the accumulation of extracellular matrix components in lupus nephritis and that the beneficial effect...