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Keywords: Extracellular matrix
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Clin Sci (Lond) (2021) 135 (9): 1127–1143.
Published: 11 May 2021
... resulted in full-term, appropriately grown fetuses delivered via cesarean section in the absence of labor (control). On a cellular level, villous stroma is composed primarily of pericytes, Hofbauer cells, and fibroblasts (FBs), with FBs acting as the main cell type driving extracellular matrix...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (20): 2681–2706.
Published: 21 October 2020
...Kaj E.C. Blokland; Simon D. Pouwels; Michael Schuliga; Darryl A. Knight; Janette K. Burgess The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells providing structural support and stability to tissues. The understanding of the ECM and the diverse roles it plays in...
Clin Sci (Lond) (2020) 134 (17): 2399–2418.
Published: 16 September 2020
...Yoshito Yamashiro; Hiromi Yanagisawa Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel wall and coordinates with a dynamic mechanical environment to provide...
Clin Sci (Lond) (2019) 133 (6): 739–740.
Published: 19 March 2019
... broadly defined ‘excess’ Na + as the increase in tissue Na + content, usually with an increase in dietary Na + , that is not accounted for by an isonatric gain of fluid (assuming a fixed plasma [Na + ] for simplicity): Extracellular Matrix Sodium Tonicity © 2019 The Author(s). Published by...
Clin Sci (Lond) (2019) 133 (1): 83–99.
Published: 11 January 2019
... potential of ADAM8. Current knowledge of substrates and interaction partners gave rise to the hypothesis that ADAM8 dysregulation affects diverse processes in tumor biology, attributable to different functional cores of the multidomain enzyme. Proteolytic degradation of extracellular matrix (ECM) components...
Clin Sci (Lond) (2017) 131 (12): 1261–1281.
Published: 07 June 2017
... wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family important in the control of extracellular matrix (ECM) remodelling. In the present study, the association of serum TSP-1 concentration with AAA progression was assessed in 276 men that underwent repeated...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (12): 1301–1315.
Published: 07 June 2017
... with diabetes, thereby facilitating extracellular matrix (ECM) stabilization. Correspondence: Paola Dongiovanni ( paola.dongiovanni@policlinico.mi.it ) or Luca Valenti ( luca.valenti@unimi.it ) * These authors contributed equally to this work. 26 02 2017 10 04 2017 02 05...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (7): 515–531.
Published: 17 March 2017
... extracellular matrix (ECM) function. In addition, genetic studies in ‘sporadic’ SVD have also shown that the disease is highly heritable, particularly among young-onset stroke patients, and that common variants in monogenic disease genes may contribute to disease processes in some SVD subtypes. Genetic studies...
Clin Sci (Lond) (2017) 131 (6): 425–437.
Published: 06 March 2017
... factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension. The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix (ECM). Elasticity is lost in fibrotic cerebral vessels, reducing the...
Clin Sci (Lond) (2016) 130 (14): 1221–1236.
Published: 01 June 2016
... with the extracellular matrix (ECM), which are mediated by anchoring filaments (AFs). The ECM protein EMILIN1 is a component of AFs and is involved in the regulation of lymphatic vessel functions: accordingly, Emilin1 −/− mice display lymphatic vascular morphological alterations, leading to functional...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (12): 1107–1113.
Published: 22 October 2015
... with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional alterations of cells...
Clin Sci (Lond) (2015) 129 (12): 1077–1081.
Published: 13 October 2015
... called ‘synthetic’, phenotype. Synthetic VSMCs are able to proliferate, migrate and secrete ECM (extracellular matrix) proteinases and ECM proteins. In addition, they produce pro-inflammatory molecules, providing an inflammatory microenvironment for leucocyte penetration, accumulation and activation. The...
Clin Sci (Lond) (2014) 126 (4): 275–288.
Published: 14 October 2013
... compilation © 2014 Biochemical Society 2014 angiotensin II (AngII) autoinduction cardiac hypertrophy extracellular matrix signalling transforming growth factor-β (TGF- β) • Excessive activation of the AngII/TGF-β axis is thought to play a central role in the transition from compensatory...
Clin Sci (Lond) (2013) 124 (3): 123–137.
Published: 02 October 2012
... on the development of atherosclerosis; and (iv) the role of FXIIIa on matrix deposition and tissue repair, including cross-linking of extracellular matrix proteins, such as fibronectin, collagen and von Willebrand factor, and the effects on matrix deposition and cell–matrix interactions. The review...
Clin Sci (Lond) (2007) 112 (4): 229–239.
Published: 17 January 2007
..., TIMP-2 and TIMP-3). An imbalance of extracellular matrix production/degradation was thus observed in veins as well as in the skin of the patients with varicose veins and, taken together, these findings show that remodelling is present in different organs, confirming systemic alterations of connective...
Clin Sci (Lond) (2004) 106 (3): 301–306.
Published: 01 March 2004
... aortic aneurysm cytokine extracellular matrix integrin metalloproteinase Clinical Science (2004) 106, 301 306 (Printed in Great Britain) 301 Expression and localization of tumour necrosis factor- and its converting enzyme in human abdominal aortic aneurysm Hidetoshi SATOH , Motoyuki NAKAMURA...
Clin Sci (Lond) (1997) 93 (2): 97–108.
Published: 01 August 1997
... acid receptors); (iv) factors which regulate detachment from the extracellular matrix (e.g. urokinase-type plasminogen activator, matrix metalloproteinases); and (iv) molecules which regulate cytoskeletal function (e.g. Rac), which allows the formation of specialized cellular processes termed...
Clin Sci (Lond) (1997) 92 (2): 113–122.
Published: 01 February 1997
... future therapeutic strategy aimed at transplanting genetically modified oligodendrocyte precursors to repair widespread demyelinated lesions. © 1997 The Biochemical Society and the Medical Research Society 1997 demyelination extracellular matrix integrin migration multiple sclerosis...
Clin Sci (Lond) (1993) 85 (3): 295–301.
Published: 01 September 1993
... were suppressed by treatment with methylprednisolone. 8. These data suggest that abnormal regulation of the genes for metalloproteinases and tissue inhibitor of metalloproteinases contribute to the accumulation of extracellular matrix components in lupus nephritis and that the beneficial effect of...