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Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury

Desmond Moronge, Hannah Godley, Victor Ayulo, Elisabeth Mellott, Mona Elgazzaz, Gibson Cooper, Riyaz Mohamed, Safia Ogbi, Ellen Gillis, Jessica L. Faulkner, Jennifer C. Sullivan

Clin Sci (Lond) (2025) 139 (04): 309–323.

https://doi.org/10.1042/CS20241851

Published: 19 February 2025

...), and NGAL were quantified via assay kits or immunoblotting. Kidneys were processed for histological analysis to assess tubular injury and fibrosis, and for electron microscopy to examine mitochondrial morphology. Immunoblots on kidney homogenates were performed to determine oxidative stress and apoptosis...

View article titled, Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury

Includes: Supplementary data

Articles

Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients

Stephen Rankin, Caitlin Fountain, Alastair J. Gemmell, Daire Quinn, Alasdair Henderson, John McClure, Sandy Small, Balaji Venugopal, Pamela McKay, Piotr J. Slomka, David Colville, Mark C. Petrie, Giselle C. Meléndez, Ninian N. Lang

Clin Sci (Lond) (2025) 139 (1): 29–41.

https://doi.org/10.1042/CS20241529

Published: 15 January 2025

... therapies but are associated with arterial injury. Histopathological insights have been limited to small animal models, and the role of inflammation in the arterial toxic effects of anthracycline is unclear in humans. Our aims were (1) to evaluate aortic media fibrosis and injury in non-human primates...

View article titled, Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients

Includes: Supplementary data

Articles

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham

Clin Sci (Lond) (2023) 137 (8): 617–631.

https://doi.org/10.1042/CS20220642

Published: 21 April 2023

... by spontaneous resolution. Three sequential exposures resulted in a persistent PH phenotype. Inflammatory cytokines were not significantly different between mice exposed to one or three egg doses, but there was an increase in perivascular fibrosis in those who received three egg doses. Significant perivascular...

View article titled, Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Includes: Supplementary data

Articles

Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Raffaele Altara, George W. Booz

Clin Sci (Lond) (2023) 137 (2): 143–148.

https://doi.org/10.1042/CS20220776

Published: 18 January 2023

.... They reported that loss of BRAF attenuated both pathological cardiac hypertrophy and interstitial fibrosis. BRAF knockout decreased cardiac function with PE in male mice and enhanced both interstitial and perivascular cardiac fibrosis but had no effect on hypertrophy. In contrast, loss of BRAF attenuated...

View article titled, Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Articles

Set7 methyltransferase roles in myocardial protection from chronic stressors

James T. Pearson

Clin Sci (Lond) (2023) 137 (1): 105–108.

https://doi.org/10.1042/CS20220773

Published: 05 January 2023

... of the Biochemical Society 2023 13 12 2022 20 12 2022 21 12 2022 Correspondence: James T. Pearson ( [email protected] ) cardiac hypertrophy fibrosis histones methylation methyltransferases Set7 Posttranslational modifications (PTMs) of histones influence chromatin...

View article titled, Set7 methyltransferase roles in myocardial protection from chronic stressors

Articles

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2022) 136 (22): 1661–1681.

https://doi.org/10.1042/CS20220607

Published: 21 November 2022

.... with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hypertension) is associated with additional features including increased fibrosis and can lead to heart failure. RAF kinases (ARAF/BRAF/RAF1) integrate signals into the extracellular signal-regulated...

View article titled, Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Includes: Supplementary data

Articles

Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction

Guilherme Lunardon, Tábatha de Oliveira Silva, Caroline A. Lino, Yao Wei Lu, Juliane B. Miranda, Paula F. Asprino, Amanda de Almeida Silva, Gabrielle T. Nepomuceno, Maria Cláudia Costa Irigoyen, Marcela S. Carneiro-Ramos, Ana Paula C. Takano, Herculano da Silva Martinho, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

Clin Sci (Lond) (2022) 136 (21): 1537–1554.

https://doi.org/10.1042/CS20220466

Published: 10 November 2022

... with isoproterenol displayed a decrease in Set7 activity in the heart. In addition, WT and Set7 KO mice injected with isoproterenol exhibited cardiac hypertrophy. Interestingly, Set7 deletion exacerbated cardiac hypertrophy in response to isoproterenol but attenuated myocardial fibrosis. Echocardiograms revealed...

View article titled, Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction

Includes: Supplementary data

Articles

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver

Clin Sci (Lond) (2022) 136 (19): 1405–1423.

https://doi.org/10.1042/CS20210889

Published: 14 October 2022

...Amy Lewis; Saray Sánchez; Giulio Berti; Belen Pan-Castillo; Anke Nijhuis; Shameer Mehta; Liliane Eleid; Hannah Gordon; Radha Gadhok; Christopher Kimberley; Annamaria Minicozzi; Joanne Chin-Aleong; Roger Feakins; Robert Kypta; James Oliver Lindsay; Andrew Silver Intestinal fibrosis and stricture...

View article titled, Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Includes: Supplementary data

Articles

The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol, Frédéric Jaisser

Clin Sci (Lond) (2022) 136 (12): 1005–1017.

https://doi.org/10.1042/CS20220212

Published: 29 June 2022

... option to slow CKD progression and provide cardiovascular protection in patients with T2D and CKD. aldosterone fibrosis inflammation Preclinical data support direct anti-fibrotic and anti-inflammatory effects of finerenone in cardiorenal protection in the presence or absence of diabetes...

View article titled, The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Articles

Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

https://doi.org/10.1042/CS20210509

Published: 07 February 2022

..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...

View article titled, Emergent players in renovascular disease

Articles

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega

Clin Sci (Lond) (2021) 135 (16): 1999–2029.

https://doi.org/10.1042/CS20201016

Published: 24 August 2021

... in renal structures. Tubulointerstitial fibrosis is observed in glomerular diseases as well as in the regeneration failure of acute kidney injury (AKI). Therefore, finding antifibrotic therapies comprises an intensive research field in Nephrology. Nowadays, ECM is not only considered as a cellular scaffold...

View article titled, Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Articles

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

In Collection

Cardiovascular-Oncology

Daniel N. Meijles, Joshua J. Cull, Susanna T.E. Cooper, Thomais Markou, Michelle A. Hardyman, Stephen J. Fuller, Hajed O. Alharbi, Zoe H.R. Haines, Viridiana Alcantara-Alonso, Peter E. Glennon, Mary N. Sheppard, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2021) 135 (14): 1631–1647.

https://doi.org/10.1042/CS20210192

Published: 23 July 2021

..., raising the question of whether dabrafenib is cardiotoxic. In the heart, ERK1/2 signalling promotes not only cardiomyocyte hypertrophy and is cardioprotective but also promotes fibrosis. Our hypothesis is that ERK1/2 signalling is not required in a non-stressed heart but is required for cardiac...

View article titled, The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

Includes: Supplementary data

Articles

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu

Clin Sci (Lond) (2020) 134 (23): 3175–3193.

https://doi.org/10.1042/CS20201207

Published: 09 December 2020

...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...

View article titled, Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Includes: Supplementary data

Articles

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

Kaj E.C. Blokland, Simon D. Pouwels, Michael Schuliga, Darryl A. Knight, Janette K. Burgess

Clin Sci (Lond) (2020) 134 (20): 2681–2706.

https://doi.org/10.1042/CS20190893

Published: 21 October 2020

... leading to tissue dysfunction, and is a risk factor in many diseases including cardiovascular disease, diabetes, cancer, dementia, glaucoma, chronic obstructive pulmonary disease (COPD) and fibrosis. ECM changes are recognised as a major driver of aberrant cell responses. Mesenchymal cells in aged tissue...

View article titled, Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

Articles

Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

Hung-Tsung Wu, Lin Kang, Yu-Chu Su, Horng-Yih Ou, Fu-Yu Chan, Yi-Cheng Chen, Bing-Hua Su, Yi-Shiang Wang, Chao-Liang Wu, Ai-Li Shiau, Pensée Wu

Clin Sci (Lond) (2020) 134 (18): 2435–2445.

https://doi.org/10.1042/CS20200147

Published: 25 September 2020

... health issues worldwide. GDM increases the risks of macrosomia, premature infants, and preeclampsia. Although placental dysfunction, including fibrosis is associated with the development of GDM, factors that link these observations remain unknown. Prothymosin α (ProTα) is expressed in the placenta...

View article titled, Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

Articles

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

Jessica P.E. Davis, Stephen H. Caldwell

Clin Sci (Lond) (2020) 134 (16): 2189–2201.

https://doi.org/10.1042/CS20191102

Published: 26 August 2020

...Jessica P.E. Davis; Stephen H. Caldwell Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal...

View article titled, Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

Articles

A tangled tale of microRNA and cardiac fibrosis

Mark Chandy

Clin Sci (Lond) (2019) 133 (21): 2217–2220.

https://doi.org/10.1042/CS20190866

Published: 13 November 2019

...Mark Chandy Cardiac fibrosis is important for wound healing, regeneration and producing the extracellular matrix (ECM) that provides the scaffold for cells. In pathological situations, fibroblasts are activated and remodel the ECM. In volume 133, issue 17 of Clinical Science , Yang et al...

View article titled, A tangled tale of microRNA and cardiac fibrosis

Articles

Effect of mycophenolate and rapamycin on renal fibrosis in lupus nephritis

Chenzhu Zhang, Caleb C.Y. Chan, Kwok Fan Cheung, Mel K.M. Chau, Desmond Y.H. Yap, Maggie K.M. Ma, Kwok Wah Chan, Susan Yung, Tak Mao Chan

Clin Sci (Lond) (2019) 133 (15): 1721–1744.

https://doi.org/10.1042/CS20190536

Published: 05 August 2019

...Chenzhu Zhang; Caleb C.Y. Chan; Kwok Fan Cheung; Mel K.M. Chau; Desmond Y.H. Yap; Maggie K.M. Ma; Kwok Wah Chan; Susan Yung; Tak Mao Chan Lupus nephritis (LN) leads to chronic kidney disease (CKD) through progressive fibrosis. Mycophenolate inhibits inosine monophosphate dehydrogenase...

View article titled, Effect of mycophenolate and rapamycin on renal fibrosis in lupus nephritis

Articles

Histamine and diabetic nephropathy: an up-to-date overview

Alessandro Pini, Roberta Verta, Cristina Grange, Maura Gurrieri, Arianna Carolina Rosa

Clin Sci (Lond) (2019) 133 (1): 41–54.

https://doi.org/10.1042/CS20180839

Published: 03 January 2019

... may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy. * These authors contributed equally to this work. 25 09 2018 22 11 2018 10 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf...

View article titled, Histamine and diabetic nephropathy: an up-to-date overview

Articles

Novel role for cardiac myocyte-derived β-2 microglobulin in mediating cardiac fibrosis

Michael J. Boyer, Satoru Eguchi

Clin Sci (Lond) (2018) 132 (19): 2117–2120.

https://doi.org/10.1042/CS20180681

Published: 05 October 2018

... promoting fibrosis. Here, we will discuss the background, significance of the study, alternative mechanisms, and future directions. Correspondence: Satoru Eguchi ( [email protected] ) 21 08 2018 12 09 2018 17 09 2018 © 2018 The Author(s). Published by Portland Press Limited...

View article titled, Novel role for cardiac myocyte-derived β-2 microglobulin in mediating cardiac fibrosis

Articles

The use of hydrogels for cell-based treatment of chronic kidney disease

Meg L. McFetridge, Mark P. Del Borgo, Marie-Isabel Aguilar, Sharon D. Ricardo

Clin Sci (Lond) (2018) 132 (17): 1977–1994.

https://doi.org/10.1042/CS20180434

Published: 14 September 2018

... of renal function leading to end-stage renal disease (ESRD). The accumulation of interstitial collagen is a hallmark of CKD caused by inflammation, leading to the development of fibrosis. CKD is an age-related disease [ 2 ], and is strongly associated with co-morbidities such as obesity, hypertension...

View article titled, The use of hydrogels for cell-based treatment of chronic kidney disease

Articles

Mechanical stresses induce paracrine β-2 microglobulin from cardiomyocytes to activate cardiac fibroblasts through epidermal growth factor receptor

Yang Li, Xiaoyi Zhang, Lu Li, Xiang Wang, Zhidan Chen, Xingxu Wang, Ying Wang, Le Kang, Yong Ye, Jianguo Jia, Guoping Zhang, Chunjie Yang, Jie Yuan, Jingmin Zhou, Junbo Ge, Hui Gong, Yunzeng Zou

Clin Sci (Lond) (2018) 132 (16): 1855–1874.

https://doi.org/10.1042/CS20180486

Published: 30 August 2018

...-dependent manner. Exogenous β2M showed pro-fibrotic effects in cultured cardiac fibroblasts but few effects in cardiomyocytes. Adeno-associated virus 9 (AAV9)-mediated knockdown of β2M significantly reduced cardiac β2M level and inhibited myocardial fibrosis and cardiac dysfunction but not cardiac...

View article titled, Mechanical stresses induce paracrine β-2 microglobulin from cardiomyocytes to activate cardiac fibroblasts through epidermal growth factor receptor

Includes: Supplementary data

Articles

Cirrhosis regression: extrahepatic angiogenesis and liver hyperarterialization persist

Audrey Payancé, Pierre-Emmanuel Rautou

Clin Sci (Lond) (2018) 132 (12): 1341–1343.

https://doi.org/10.1042/CS20180129

Published: 28 June 2018

... Mauro E. , Crespo G. , Montironi C. , Londoño M.-C. , Hernández-Gea V. , Ruiz P. ( 2017 ) Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C . Hepatology 10.1002/hep...

View article titled, Cirrhosis regression: extrahepatic angiogenesis and liver hyperarterialization persist

Articles

More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases

Mathieu Buonafine, Ernesto Martinez-Martinez, Frédéric Jaisser

Clin Sci (Lond) (2018) 132 (9): 909–923.

https://doi.org/10.1042/CS20171592

Published: 08 May 2018

... Cardiovascular fibrosis inflammation MR NGAL renal Apart from MMP-9, NGAL is also able to interact with other ligands, particularly certain bacterial siderophores ( Figure 2 ). Neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin-2, 24p3, siderocalin, or uterocalin, is a small...

View article titled, More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases

Articles

Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets

Mathew Suji Eapen, Sukhwinder Singh Sohal

Clin Sci (Lond) (2018) 132 (3): 375–379.

https://doi.org/10.1042/CS20171261

Published: 08 February 2018

... phenotype in the airway wall as well as resolving the existing M2 AMs and enhancing their phagocytic activity. chronic obstructive pulmonary disease drug therapy fibrosis infection inflammation Pulmonary infections are a leading cause of mortality worldwide. According to the World Health...

View article titled, Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets

Articles

Dual αvβ3 and αvβ5 blockade attenuates fibrotic and vascular alterations in a murine model of systemic sclerosis

Gian Luca Bagnato, Natasha Irrera, Gabriele Pizzino, Domenico Santoro, William Neal Roberts, Gianfilippo Bagnato, Giovanni Pallio, Mario Vaccaro, Francesco Squadrito, Antonino Saitta, Domenica Altavilla, Alessandra Bitto

Clin Sci (Lond) (2018) 132 (2): 231–242.

https://doi.org/10.1042/CS20171426

Published: 19 January 2018

... by fibroblast activation and fibrosis of the skin and internal organs. Alterations in cell–integrin interaction are sufficient to initiate profibrotic processes. SSc fibroblasts express both αvβ3 and αvβ5 integrins and their activation induces myofibroblasts differentiation. The aim of the present study...

View article titled, Dual αvβ3 and αvβ5 blockade attenuates fibrotic and vascular alterations in a murine model of systemic sclerosis

Articles

A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis

Vanessa Arrieta, Ernesto Martinez-Martinez, Jaime Ibarrola, Virginia Alvarez, Rafael Sádaba, Amaia Garcia-Peña, Amaya Fernández-Celis, Victoria Cachofeiro, Patrick Rossignol, Natalia López-Andrés

Clin Sci (Lond) (2017) 131 (10): 935–949.

https://doi.org/10.1042/CS20170145

Published: 04 May 2017

...Vanessa Arrieta; Ernesto Martinez-Martinez; Jaime Ibarrola; Virginia Alvarez; Rafael Sádaba; Amaia Garcia-Peña; Amaya Fernández-Celis; Victoria Cachofeiro; Patrick Rossignol; Natalia López-Andrés Aortic stenosis (AS) is characterized by pressure overload and causes left ventricular (LV) fibrosis...

View article titled, A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis

Includes: Supplementary data

Articles

Chronic kidney disease

Christian Delles, Raymond Vanholder

Clin Sci (Lond) (2017) 131 (3): 225–226.

https://doi.org/10.1042/CS20160624

Published: 05 January 2017

... kidney disease cardiovascular disease fibrosis translational science Chronic kidney disease (CKD) is characterized by persisting renal damage and/or loss of renal function. The condition is associated with high morbidity and mortality throughout the continuum from early disease to advanced...

View article titled, Chronic kidney disease

Articles

Mas receptor contributes to pregnancy-induced cardiac remodelling

Cintia do Carmo e Silva, Jônathas Fernandes Queiroz de Almeida, Larissa Matuda Macedo, Marcos Barrouin Melo, Gustavo Rodrigues Pedrino, Fernanda Cristina Alcantara dos Santos, Manoel Francisco Biancardi, Robson Augusto Souza dos Santos, Adryano Augustto Valladão de Carvalho, Elizabeth Pereira Mendes, Diego Basile Colugnati, Renata Mazaro-Costa, Carlos Henrique de Castro

Clin Sci (Lond) (2016) 130 (24): 2305–2316.

https://doi.org/10.1042/CS20160095

Published: 10 November 2016

.... However, the role of the Ang-(1–7)/Mas receptor on pregnancy-induced cardiac remodelling remains unknown. The objective of the present study was to evaluate the participation of the Mas receptor in the development of the cardiac hypertrophy and fibrosis induced by gestation. Female Wistar rats were...

View article titled, Mas receptor contributes to pregnancy-induced cardiac remodelling

Includes: Supplementary data

Articles

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

Simon G. Royce, Anna M. Tominaga, Matthew Shen, Krupesh P. Patel, Brooke M. Huuskes, Rebecca Lim, Sharon D. Ricardo, Chrishan S. Samuel

Clin Sci (Lond) (2016) 130 (23): 2151–2165.

https://doi.org/10.1042/CS20160328

Published: 20 October 2016

...) and total collagen deposition, markers of collagen turnover and AHR compared with that in saline-treated counterparts (all P <0.01 compared with saline-treated controls). RLX or AECs (but not MSCs) alone normalized epithelial thickness and partially diminished the OVA-induced fibrosis and AHR by ∼40–50...

View article titled, Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

Articles

Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice

Iris Schuster, Shokoufeh Mahmoodzadeh, Elke Dworatzek, Frédéric Jaisser, Smail Messaoudi, Ingo Morano, Vera Regitz-Zagrosek

Clin Sci (Lond) (2016) 130 (5): 365–376.

https://doi.org/10.1042/CS20150609

Published: 26 January 2016

... reduction of SERCA2a (sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase 2a) expression after MI, suggesting less reduction in diastolic Ca 2+ -reuptake into the sarcoplasmic reticulum post-MI. Secondly, male ERβ-OE revealed attenuated cardiac fibrosis in the remote LV tissue and expression of fibrosis...

View article titled, Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice

Includes: Supplementary data

Articles

FasL expression in cardiomyocytes activates the ERK1/2 pathway, leading to dilated cardiomyopathy and advanced heart failure

Anne-Cecile Huby, Subat Turdi, Jeanne James, Jeffrey A. Towbin, Enkhsaikhan Purevjav

Clin Sci (Lond) (2016) 130 (4): 289–299.

https://doi.org/10.1042/CS20150624

Published: 14 January 2016

..., the underlying mechanism(s) of FasL-related deterioration of heart function remain obscure. The aim of the present study is to determine roles of myocardial FasL in the activation of alternative pathways such as extracellular-signal-regulated kinase 1/2 (ERK1/2), inflammation or fibrosis and to identify...

View article titled, FasL expression in cardiomyocytes activates the ERK1/2 pathway, leading to dilated cardiomyopathy and advanced heart failure

Includes: Supplementary data

Articles

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

Aaron D. McClelland, Michal Herman-Edelstein, Radko Komers, Jay C. Jha, Catherine E. Winbanks, Shinji Hagiwara, Paul Gregorevic, Phillip Kantharidis, Mark E. Cooper

Clin Sci (Lond) (2015) 129 (12): 1237–1249.

https://doi.org/10.1042/CS20150427

Published: 11 November 2015

... (miR) miR-21 as a key modulator of its prosclerotic actions. In the present study, we demonstrate data indicating that miR-21 up-regulation positively correlates with the severity of fibrosis and rate of decline in renal function in human DN. Furthermore, concomitant analyses of various models...

View article titled, miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

Includes: Supplementary data

Articles

Cellular and molecular mechanisms of HGF/Met in the cardiovascular system

Simona Gallo, Valentina Sala, Stefano Gatti, Tiziana Crepaldi

Clin Sci (Lond) (2015) 129 (12): 1173–1193.

https://doi.org/10.1042/CS20150502

Published: 11 November 2015

..., HGF/Met antagonizes the actions of TGFβ 1 (transforming growth factor β 1 ) and AngII (angiotensin II), thus preventing fibrosis. Moreover, HGF/Met influences the inflammatory response of macrophages and the immune response of dendritic cells, indicating its protective function against atherosclerotic...

View article titled, Cellular and molecular mechanisms of HGF/Met in the cardiovascular system

Articles

Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions

Satoshi Kubota, Masaharu Takigawa

Clin Sci (Lond) (2015) 128 (3): 181–196.

https://doi.org/10.1042/CS20140264

Published: 03 October 2014

..., such as cartilage and bone, in the skeletal system, by manipulating extracellular signalling molecules involved therein by acting as a hub through a web. However, on the other hand, CCN2 occasionally plays profound roles in major human biological disorders, including fibrosis and malignancies in major organs...

View article titled, Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions

Articles

Disruption of histamine H 2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis

Zhi Zeng, Liang Shen, Xixian Li, Tao Luo, Xuan Wei, Jingwen Zhang, Shiping Cao, Xiaobo Huang, Yasushi Fukushima, Jianping Bin, Masafumi Kitakaze, Dingli Xu, Yulin Liao

Clin Sci (Lond) (2014) 127 (7): 435–448.

https://doi.org/10.1042/CS20130716

Published: 17 June 2014

...), but the mechanisms involved are not entirely clear. In the present study, we assessed the influences of H2R disruption on left ventricular (LV) dysfunction and the mechanisms involved in mitochondrial dysfunction and calcineurin-mediated myocardial fibrosis. H2R-knockout mice and their wild-type littermates were...

View article titled, Disruption of histamine H 2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis

Includes: Supplementary data

Articles

In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts

Anke Nijhuis, Paolo Biancheri, Amy Lewis, Cleo L. Bishop, Paolo Giuffrida, Christopher Chan, Roger Feakins, Richard Poulsom, Antonio Di Sabatino, Gino Roberto Corazza, Thomas T. MacDonald, James O. Lindsay, Andrew R. Silver

Clin Sci (Lond) (2014) 127 (5): 341–350.

https://doi.org/10.1042/CS20140048

Published: 15 May 2014

...Anke Nijhuis; Paolo Biancheri; Amy Lewis; Cleo L. Bishop; Paolo Giuffrida; Christopher Chan; Roger Feakins; Richard Poulsom; Antonio Di Sabatino; Gino Roberto Corazza; Thomas T. MacDonald; James O. Lindsay; Andrew R. Silver Intestinal fibrosis with stricture formation is a complication of CD...

View article titled, In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts

Includes: Supplementary data

Articles

Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication

Steve S. Choi, Lee C. Claridge, Ravi Jhaveri, Marzena Swiderska-Syn, Paul Clark, Ayako Suzuki, Thiago A. Pereira, Zhiyong Mi, Paul C. Kuo, Cynthia D. Guy, Fausto E. L. Pereira, Anna Mae Diehl, Keyur Patel, Wing-Kin Syn

Clin Sci (Lond) (2014) 126 (12): 845–855.

https://doi.org/10.1042/CS20130473

Published: 26 February 2014

... during chronic liver injury and directly promotes fibrosis. We have reported that Hh signalling enhances viral permissiveness and replication in HCV (hepatitis C virus)-infected cells. Hence we hypothesized that OPN directly promotes HCV replication, and that targeting OPN could be beneficial in HCV...

View article titled, Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication

Articles

Innate immunity in systemic sclerosis pathogenesis

Steven O’Reilly

Clin Sci (Lond) (2014) 126 (5): 329–337.

https://doi.org/10.1042/CS20130367

Published: 25 October 2013

... (systemic sclerosis). SSc is an autoimmune disorder in which vascular injury occurs and there is a chronic low-grade inflammation followed by excessive ECM (extracellular matrix) deposition and ultimately fibrosis. The fibrosis ultimately leads to organ dysfunction and death. The preceding vascular damage...

View article titled, Innate immunity in systemic sclerosis pathogenesis

Articles

N -acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats

Germán E. González, Nour-Eddine Rhaleb, Pablo Nakagawa, Tang-Dong Liao, Yunhe Liu, Pablo Leung, Xiangguo Dai, Xiao-Ping Yang, Oscar A. Carretero

Clin Sci (Lond) (2014) 126 (1): 85–94.

https://doi.org/10.1042/CS20120619

Published: 09 September 2013

...Germán E. González; Nour-Eddine Rhaleb; Pablo Nakagawa; Tang-Dong Liao; Yunhe Liu; Pablo Leung; Xiangguo Dai; Xiao-Ping Yang; Oscar A. Carretero We have reported previously that Ac-SDKP ( N -acetyl-seryl-aspartyl-lysyl-proline) reduces fibrosis and inflammation (in macrophages and mast cells...

View article titled, N -acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats

Articles

Histone deacetylases as targets for treatment of multiple diseases

Jinhua Tang, Haidong Yan, Shougang Zhuang

Clin Sci (Lond) (2013) 124 (11): 651–662.

https://doi.org/10.1042/CS20120504

Published: 15 February 2013

... and the pathogenesis of some diseases. Recently, HDACs have come to be considered crucial targets in various diseases, including cancer, interstitial fibrosis, autoimmune and inflammatory diseases, and metabolic disorders. Pharmacological inhibitors of HDACs have been used or tested to treat those diseases...

View article titled, Histone deacetylases as targets for treatment of multiple diseases

Articles

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

Juan F. Santibañez, Miguel Quintanilla, Carmelo Bernabeu

Clin Sci (Lond) (2011) 121 (6): 233–251.

https://doi.org/10.1042/CS20110086

Published: 27 May 2011

... regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal...

View article titled, TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

Includes: Supplementary data

Articles

At the heart of tissue: endothelin system and end-organ damage

Marc Iglarz, Martine Clozel

Clin Sci (Lond) (2010) 119 (11): 453–463.

https://doi.org/10.1042/CS20100222

Published: 17 August 2010

...Marc Iglarz; Martine Clozel ET (endothelin)-1 was first described as a potent vasoconstrictor. Since then, many other deleterious properties mediated via its two receptors, ET A and ET B , have been described, such as inflammation, fibrosis and hyperplasia. These effects, combined with a wide...

View article titled, At the heart of tissue: endothelin system and end-organ damage

Articles

Role of nuclear factor κB in liver health and disease

Stuart M. Robinson, Derek A. Mann

Clin Sci (Lond) (2010) 118 (12): 691–705.

https://doi.org/10.1042/CS20090549

Published: 30 March 2010

... [IκB (inhibitor of κB) kinase] complex and the RelA subunit. We explore the weaknesses of the experimental approaches to date and suggest that further work is needed to investigate in detail the discreet functions of each of the Rel subunits in liver physiology and disease. fibrosis...

View article titled, Role of nuclear factor κB in liver health and disease

Articles

Prevention of myocardial fibrosis by N -acetyl-seryl-aspartyl-lysyl-proline in diabetic rats

Giovanna Castoldi, Cira R. T. Di Gioia, Camila Bombardi, Carla Perego, Lucia Perego, Massimiliano Mancini, Martina Leopizzi, Barbara Corradi, Stefano Perlini, Gianpaolo Zerbini, Andrea Stella

Clin Sci (Lond) (2010) 118 (3): 211–220.

https://doi.org/10.1042/CS20090234

Published: 01 February 2010

..., and interstitial and perivascular fibrosis in the heart of diabetic rats. Diabetes was induced in 55 Sprague–Dawley rats by streptozotocin injection. Control rats ( n =18) underwent only buffer injection. Out of the 55 diabetic rats, 19 were chronically treated with insulin and 13 with the ACEI (ACE inhibitor...

View article titled, Prevention of myocardial fibrosis by N -acetyl-seryl-aspartyl-lysyl-proline in diabetic rats

Articles

Development of hepatic fibrosis occurs normally in AMPK-deficient mice

Alain Da Silva Morais, Jorge Abarca-Quinones, Bruno Guigas, Benoit Viollet, Peter Stärkel, Yves Horsmans, Isabelle A. Leclercq

Clin Sci (Lond) (2010) 118 (6): 411–420.

https://doi.org/10.1042/CS20090293

Published: 14 December 2009

... for the treatment of liver fibrosis. In vitro studies have shown that activation of AMPK (AMP-activated protein kinase), a key player in the regulation of cellular energy homoeostasis, inhibits proliferation of myofibroblasts derived from HSCs. If AMPK is a true regulator of fibrogenesis then defective AMPK...

View article titled, Development of hepatic fibrosis occurs normally in AMPK-deficient mice

Includes: Supplementary data

Articles

Chronic administration of ursodeoxycholic acid decreases portal pressure in rats with biliary cirrhosis

Ying-Ying Yang, Yi-Tsau Huang, Kuei-Chuan Lee, Fa-Yauh Lee, Tzung-Yan Lee, Ming-Chih Hou, Han-Chieh Lin, Shou-Dong Lee

Clin Sci (Lond) (2009) 116 (1): 71–79.

https://doi.org/10.1042/CS20080075

Published: 28 November 2008

... production and lipid peroxidation, and an increase in antioxidative defence, leading to the prevention of hepatic fibrosis. Accumulation of hydrophobic bile acids in cholestatic rat livers has been found to release ROS and increase the pro-inflammatory cytokines in rat livers [ 11 , 13 ]. Biliary cirrhosis...

View article titled, Chronic administration of ursodeoxycholic acid decreases portal pressure in rats with biliary cirrhosis

Articles

Liver fibrosis: a balance of ACEs?

Fiona J. Warner, John S. Lubel, Geoffrey W. McCaughan, Peter W. Angus

Clin Sci (Lond) (2007) 113 (3): 109–118.

https://doi.org/10.1042/CS20070026

Published: 02 July 2007

...Fiona J. Warner; John S. Lubel; Geoffrey W. McCaughan; Peter W. Angus There is an increasing body of evidence to suggest that the RAS (renin–angiotensin system) contributes to tissue injury and fibrosis in chronic liver disease. A number of studies have shown that components of a local hepatic RAS...

View article titled, Liver fibrosis: a balance of ACEs?

Articles

Liver fibrosis: cellular mechanisms of progression and resolution

Neil C. Henderson, John P. Iredale

Clin Sci (Lond) (2007) 112 (5): 265–280.

https://doi.org/10.1042/CS20060242

Published: 01 February 2007

...Neil C. Henderson; John P. Iredale Liver fibrosis represents a major worldwide health care burden. The last 15 years have seen a rapid growth in our understanding of the pathogenesis of this clinically relevant model of inflammation and repair. This work is likely to inform the design of effective...

View article titled, Liver fibrosis: cellular mechanisms of progression and resolution

Articles

Structural changes in the airways in asthma: observations and consequences

Tony R. BAI, Darryl A. KNIGHT

Clin Sci (Lond) (2005) 108 (6): 463–477.

https://doi.org/10.1042/CS20040342

Published: 24 May 2005

... and abnormalities in elastin. Genetic influences, as well as fetal and early life exposures, may contribute to structural changes such as subepithelial fibrosis from an early age. Other structural alterations are related to duration of disease and/or long-term uncontrolled inflammation. The increase in smooth...

View article titled, Structural changes in the airways in asthma: observations and consequences

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