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Keywords: G-protein-coupled receptors
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Clin Sci (Lond) (2021) 135 (16): 1945–1980.
Published: 17 August 2021
... oxygenases. The actions of the above eicosanoids are mediated by approximately 20 G protein-coupled receptors, resulting in a variety of both detrimental and beneficial effects on airway smooth muscle and inflammatory cells that are strongly implicated in asthma pathophysiology. Drugs targeting...
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Clin Sci (Lond) (2019) 133 (7): 853–857.
Published: 04 April 2019
...-A (OR-A) and orexin-B (OR-B), derive from a common precursor, pre-pro-orexin, and act through two G protein-coupled receptors, orexin-1 (OX1R) and orexin-2 (OX2R) receptors. OR-A has equal affinity for both OX1R and OX2R, while OR-B has a higher affinity for OX2R [ 2–4 ]. OXRs are widely distributed through both...