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Keywords: G-protein-coupled receptors
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Articles
Marharyta Semenikhina, Mykhailo Fedoriuk, Mariia Stefanenko, Christine A. Klemens, Alena Cherezova, Brendan Marshall, Gentzon Hall, Vladislav Levchenko, Ashish K. Solanki, Joshua H. Lipschutz, Daria V. Ilatovskaya, Alexander Staruschenko, Oleg Palygin
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (24): 1789–1804.
Published: 21 December 2023
...) are the first-line treatment for hypertension; they act by inhibiting signaling through the angiotensin 1 receptor (AT1R). Recently, a novel biased AT1R agonist, TRV120027 (TRV), which selectively activates the β-arrestin cascade and blocks the G-protein-coupled receptor pathway has been proposed as a potential...
Articles
Nima Yassini, Janine Sprenger, Eva Maria Pastor Arroyo, Christiane Krudewig, Giovanni Pellegrini, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (14): 1013–1025.
Published: 25 July 2023
...Nima Yassini; Janine Sprenger; Eva Maria Pastor Arroyo; Christiane Krudewig; Giovanni Pellegrini; Nicole Joller; Carsten A. Wagner; Pedro Henrique Imenez Silva Ovarian cancer G protein-coupled receptor 1 (OGR1) ( Gpr68 ) and G protein-coupled receptor 4 (GPR4) ( Gpr4 ) are proton-activated G...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1945–1980.
Published: 17 August 2021
... oxygenases. The actions of the above eicosanoids are mediated by approximately 20 G protein-coupled receptors, resulting in a variety of both detrimental and beneficial effects on airway smooth muscle and inflammatory cells that are strongly implicated in asthma pathophysiology. Drugs targeting...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (7): 853–857.
Published: 04 April 2019
...-A (OR-A) and orexin-B (OR-B), derive from a common precursor, pre-pro-orexin, and act through two G protein-coupled receptors, orexin-1 (OX1R) and orexin-2 (OX2R) receptors. OR-A has equal affinity for both OX1R and OX2R, while OR-B has a higher affinity for OX2R [ 2–4 ]. OXRs are widely distributed through both...