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Keywords: HDAC3 inhibition
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Zheng Xu, Qian Tong, Zhiguo Zhang, Shudong Wang, Yang Zheng, Qiuju Liu, Ling-bo Qian, Shao-yu Chen, Jian Sun, Lu Cai
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1841–1857.
Published: 05 July 2017
... showed that HDAC3 inhibition elevated histone H3 acetylation on the DUSP5 gene promoter at both two time points. These findings suggest that diabetes-activated HDAC3 inhibits DUSP5 expression through deacetylating histone H3 on the primer region of DUSP5 gene, leading to the derepression of ERK1/2...