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Keywords: HIV
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Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
Clin Sci (Lond) (2019) 133 (8): 997–1010.
Published: 29 April 2019
... and HIV progression under suppressive combined antiretroviral therapy (cART). Integrated data from nuclear magnetic resonance (NMR)-based lipoprotein profiles, mass spectrometry (MS)-based metabolomics and soluble plasma biomarkers help to build prognostic and immunological progression tools that enable...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (6): 189–196.
Published: 12 August 2008
... has been described in HIV-positive individuals. In the present study we investigated whether HIV-positive individuals and CAD (coronary artery disease) patients have similarities in their vascular function and structure. In a case-control study, we compared measurements of carotid artery IMT (intima...
Clin Sci (Lond) (2008) 115 (6): 197–202.
Published: 12 August 2008
...Saima Qurashi; Dennis C. Mynarcik; Margaret A. McNurlan; Hongshik Ahn; Robert Ferris; Marie C. Gelato The present study was designed to investigate the relationship of isoforms of adiponectin to insulin sensitivity in subjects with HIV-associated insulin resistance in response to treatment...
Clin Sci (Lond) (2006) 110 (5): 503–524.
Published: 11 April 2006
... and disease outcomes in HIV and TB (tuberculosis). We then examine the putative role of iron-related host genes by focussing on two candidate genes, haptoglobin and NRAMP1, for which there are common polymorphic variants in humans with strong evidence of functionally distinct biochemical phenotypes that would...
Includes: Supplementary data
Clin Sci (Lond) (2006) 110 (4): 393–407.
Published: 15 March 2006
... as a primary factor in causing neuronal dysfunction or degeneration. In this review, we outline the current state of knowledge regarding the pathophysiology of CNS (central nervous system) injury in viral infection. We focus our review on the neuropathogenesis of HIV type 1 (HIV-1)-associated dementia, because...
Clin Sci (Lond) (2006) 110 (1): 59–71.
Published: 12 December 2005
...Rebekah L. Puls; Sean Emery Although effective in reducing mortality, current antiretroviral therapy for HIV infection involves complex and expensive drug regimens that are toxic and difficult to take. Eradication of HIV reservoirs is not possible with existing therapies. The concept of therapeutic...
Clin Sci (Lond) (2003) 104 (4): 437–446.
Published: 21 March 2003
...-lymphocytes. DC-SIGN can also bind HIV, and the virus may remain bound to DC-SIGN for protracted periods. DC-SIGN may deliver bound HIV to permissive cell types, mediating infection with high efficiency. A closely related C-type lectin, DC-SIGN-related molecule (DC-SIGNR) has also been described. DC-SIGNR...
Clin Sci (Lond) (2002) 102 (1): 85–90.
Published: 10 December 2001
...Marie C. GELATO; Dennis MYNARCIK; Margaret A. MCNURLAN Therapies are still being sought for the prevention of loss of body weight and lean body mass in HIV disease. The purpose of the present study was to identify a serum marker that would help in selecting patients who may be appropriate...