... and enhanced systolic function with no evidence of arrhythmia in IGF1R model, as well as ventricular hypertrophy and decreased systolic function with intermittent atrial fibrillation in DCM-dnPI3K model. Novel findings obtained from the left atrial (LA) characterization of female mice revealed...

... smooth muscle cell (VSMC) hypertrophy and phenotype changes, in the absence of extracellular matrix (ECM) proteins accumulation. Accordingly, treatment with an IL-17A neutralizing antibody diminished SMA remodeling in a model of angiotensin II (Ang II) infusion. Moreover, in vitro studies in VSMCs...

... the corresponding adult isoforms, α-MHC and α-cardiac actin, are down-regulated [ 8 , 11 ]. arrhythmogenic right ventricular (ARVC) cardiomyocyte cardiomyopathy dilated cardiomyopathy (DCM) heart failure hypertrophic cardiomyopathy (HCM) hypertrophy primary cardiomyopathy restrictive cardiomyopathy...

... variability between patients and the dynamic nature of pregnancy hampers interpretation of smaller studies, but some facts are consistent. Gestational cardiac hypertrophy and a physical shift of the heart contribute to changes in the ECG. There are also electrical changes such as an increased heart rate...

... hypertrophy • Mast cell degranulation and histamine release have been implicated in the development of HF, whereas clinical and animal experiments have indicated that H2R blockade could improve CHF, but the underlying mechanism is unclear. • The present study has shown that blocking of H2R...

... (renin–angiotensin–aldosterone system) to exert its effects. In numerous genetically modified animal models, non-specific or organ-targeted ET-1 overexpression causes intense organ damage, especially hypertrophy and fibrosis, in the absence of haemodynamic changes, confirming a local activity of the ET...

... in the process of hypertrophy. In the present study, we have investigated the relationship between GDF15 gene variants and left ventricular hypertrophy in human essential hypertension. A community-based hypertensive population sample of 1527 individuals (506 men and 1021 women) was genotyped for three GDF15...

..., but the role of individual signalling proteins in the pathogenesis of various cardiovascular diseases is still being elucidated. In the present review, the role of the MAPKs ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase) and p38 MAPK in cardiac hypertrophy, cardiac remodelling after...

... The Authors Journal compilation © 2007 Biochemical Society 2007 focal adhesion kinase (FAK) heart failure hypertrophy myocardial fibrosis signal transduction volume overload Cardiac diseases often result in adverse remodelling of the left ventricle and progression to heart failure. Complex...

...Philippa J. Talmud; David M. Flavell; Khaled Alfakih; Jackie A. Cooper; Anthony J. Balmforth; Mohan Sivananthan; Hugh E. Montgomery; Alistair S. Hall; Steve E. Humphries LVH [LV (left ventricular) hypertrophy] is an independent risk factor for CHD (coronary heart disease). During LVH, the preferred...

... the influence of various agonists or physical stress that, in the long term, also lead to development of hypertrophy. Previously, we identified three different Cl - channel activities in neonatal rat cardiomyocytes: (i) Ca 2+ regulated, (ii) cAMP regulated (cystic fibrosis transmembrane conductance regulator Cl...

... on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr Bernhard R. Brehm (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 hypertrophy protein kinase C ...

...Leong L. NG; Russell J. O'BRIEN; Bettina DEMME; Sonja JENNINGS Cardiotrophin-1 (CT-1) leads to a specific form of ventricular hypertrophy characterized by sarcomeres added in series, and has been reported to be elevated in heart failure. Previous competitive assays for CT-1 necessitate...

...Jenny A. DEAGUE; Catherine M. WILSON; Leeanne E. GRIGG; Stephen B. HARRAP Left ventricular hypertrophy is an independent cardiovascular risk factor. In hypertensives, the pattern of hypertrophy is influenced by central haemodynamic characteristics. Central haemodynamics may also determine...

.... vasculature pathophysiology ultrasound atherosclerosis hypertension radial artery hypertrophy The Biochemical Society and the Medical Research Society © 2001 2001 19 9 2000 14 12 2000 26 1 2001 Correspondence : Dr A. J. Mackay (e-mail [email protected]...

... hypertrophy left ventricle M-mode, population 377Clinical Science (1999) 97, 377 383 (Printed in Great Britain) Discrepancies between echocardiographic measurements of left ventricular mass in a healthy adult population Jenny A. DEAGUE Catherine M. WILSON , Leeanne E. GRIGG and Stephen B. HARRAP...

... myocytes in primary culture. Increased proto-oncogene expression has been implicated in the development of cardiac hypertrophy; we therefore wished to examine the effects of overexpression of the c- myc and c- fos proto-oncogenes induced by cell transfection on cell growth. 2. Neonatal rat ventricular...

... ventricular tachycardia. 6. Myocardium distant from infarction in patients with ischaemic heart disease has a normal pattern of connexin43 gap junction distribution, but has a 47% reduction in gap junction surface area per unit cell volume, and a 30% reduction per cell. 7. In hypertrophied myocardium from...

...Martin Muntzel; Thierry Hannedouche; Roberte Niesor; Laure-Helène Nöel; Jean-Claude Souberbielle; Bernard Lacour; Tilman Drüeke 1. To determine whether treatment with octreotide, a somatostatin analogue, may diminish or prevent long-term diabetic renal hypertrophy and nephropathy, uninephrectomized...

... and in the WIS 75.1 ± 7.8 mmHg ( P < 0.001). 6. These data indicate the presence of marked vascular and cardiac hypertrophy in the SHR at a very early period in its development. Blood pressure is elevated and there is no overactivity of the renin system. We conclude that, at this time...

... veins, portal pressure is a primary determinant of media thickness but not of lumen diameter. 11 1 1989 23 1 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 contractility hypertrophy mesenteric veins oesophageal varices Clinical Science (1 989...

... and the Medical Research Society 1976 deoxyribonucleic acid diabetes hyperplasia hypertrophy kidney ribonucleic acid Clinical Science and Molecular Medicine (1976) 51, 551-555. Renal hypertrophy in streptozotocin-diabetic rats K. SEYER-HANSEN Second University Clinic of Internal Medicine...