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Keywords: Hypoperfusion
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Articles

Pharmacological inhibition of TRPV4 channels protects against ischemia–reperfusion-induced renal insufficiency in neonatal pigs

Hitesh Soni, Dieniffer Peixoto-Neves, Michael A. Olushoga, Adebowale Adebiyi
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1031–1047.
https://doi.org/10.1042/CS20180815
Published: 02 May 2019
...Hitesh Soni; Dieniffer Peixoto-Neves; Michael A. Olushoga; Adebowale Adebiyi Renal vasoconstriction, an early manifestation of ischemic acute kidney injury (AKI), results in renal hypoperfusion and a rapid decline in kidney function. The pathophysiological mechanisms that underlie ischemia...
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Includes: Supplementary data
Articles

Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms

Anne Joutel, Hugues Chabriat
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (8): 635–651.
https://doi.org/10.1042/CS20160380
Published: 28 March 2017
... features of WM changes in SVDs. The most widely held view is that SVD-associated WM lesions are caused by chronic hypoperfusion, impaired cerebrovascular reactivity (CVR) or blood–brain barrier (BBB) leakage. Here, we assess the arguments for and against each of these mechanisms based on population...
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